<![CDATA[BackgroundThyroid carcinoma is the most common malignancy of the endocrine system. Some cases histopathologically have overlappingmorphological features among papillary thyroid carcinoma follicular variants and follicular adenomas; beetween nodular hyperplasiaand protruding papillary protrusion; nuclear feature and thyroid papillary carcinoma. The combination of CK19 and HBME-1imunohistochemical staining have been proven as specific and sensitive markers to distinguish benign and malignant lesions thyroid.The purpose of this study was to determine the differences in CK19 and HBME-1 expression in benign and malignant Thyroid lesions.MethodsThis study used a diagnostic test of 50 cases (16 cases of nodular hyperplasia, 8 cases of follicular adenoma, 21 papillary thyroidcarcinomas and 5 cases of thyroid follicular carcinoma) clinicopathological data were noted. Immunohistochemical staining wasperformed using CK19 and HBME-1antibodies and the their expression assessed. Data were analysed by SPSS version 22.0.ResultsBased on the four histopathological diagnoses, the majority patient, were females between 20-50 years.Fifty percent of macroscopicsample size was more than 5 cm. The expression of CK19 and HBME-1 has a sensitivity value of 76.9% and 92.3% and a specificityvalue of 79.2% and 79.2%, consecutively. While positive predictive value 80% and 82.8% and negative predictive value 76% and90.5%, accuracy of 78% and 86%, respectively.ConclusionHBME-1 expression could be used to distinguishing benign from malignan lesions of thyroid with high diagnostic sensitivity thanCK19 expression.]]>
