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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indian Journal of Forensic Medicine & Toxicology
Menul Ayu Umborowati
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Immunology & microbiology Public Health

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Journal : Indian Journal of Forensic Medicine

 1 
The Gloves as Effective Personal Protective Equipment (PPE) of Indonesian Batik Workers Cita Rosita Sigit Prakoeswa; Damayanti; Sylvia Anggraeni; Menul Ayu Umborowati; Sri Awalia Febriana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16832

Abstract

Background: Batik substances may increase the risk of biological function disruption to batik workers.Objective: To Determine the effectiveness of using test gloves in transepidermal water loss (TEWL), skinhydration level, and skin acidity (pH).Methods: This study was one group pretest-posttest design of 16 batik workers. Subjects use test glovesmade from neoprene on right hands and personal gloves made from thermoplastic polymer of vinyl chlorideon left hands in first and second week. Washed out for 2 weeks, last 2 weeks use test gloves on left handand personal gloves on right hand. TEWL, skin hydration level, and pH was examined by Cutometer dualMP-580Result: First and second week using test gloves on the right hand, significantly differences of TEWL levelon extensor and dorsum manus; skin hydration level on flexor, extensor, palmar, and dorsum manus; pHon extensor, palmar and dorsum manus (p<0.05; CI 95%). Fifth and sixth week using test gloves in theleft hand, significantly difference of TEWL level on dorsum manus, all area of skin hydration level and pHresults (p<0.05; CI 95%). No significant differences of comparison right and left hand in the first, second,fifth, and sixth week, that showed any types of gloves can protect batik workers from skin barrier disruption.Conclusion: Personal gloves and test gloves usage for protection doesn’t have much significant difference.Wearing gloves may also give risk to trigger contact dermatitis if not used properly or using incompatiblematerial.
The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress Cita Rosita Sigit Prakoeswa; Agatha Anindhita Ayu Ardhaninggar; Riyana Noor Oktaviyanti; Irmadita Citrashanty; Maylita Sari; Menul Ayu Umborowati; Dwi Murtiastutik
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14695

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and VitaminE are expected to have an effect on clinical photoaging improvement.Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedlingcompared with AMSC metabolite products after microneedling.Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matchingresearch. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E inintervention group and AMSC-MP only in control group. Microneedling modality was use to enhanceepidermal penetration. Three treatment sessions were repeated at two weeks’ interval.Results: From the comparison of the two groups showed there were significant different of mean value inwrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spotdo not show significant differences between two groups.Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedlingprovides clinical improvement in photoaging.
The Role of Aloe vera and Centella asiatica to the Improvement of Skin Barrier Function in Indonesian Batik Workers Damayanti; Menul Ayu Umborowati; Sylvia Anggraeni2; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15731

Abstract

Background: The batik industry uses dyes and candles, that can disrupt the skin barrier function and may precipitate skin disease. Objective: To determine the role of Aloe vera and Centella asiatica to the improvement of the skin barrier function in Indonesian batik workersMethods: This was a double blind clinical trial of 30 Indonesian batik workers were divided into 2 group and given Aloe vera or Centella asiatica topical randomly was applied twice a day. Transepidermal water loss (TEWL) level, stratum corneum hydration level, and pH level, were examined using Cutometer dual MP-580. Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between 15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local extracts (86.4%; 84.4%). Conclusion: Aloe vera topical gave significant improvement on palm area of TEWL level (P=0.033; CI 95%), stratum corneum hydration (P=0.000; CI 95%), and pH level (P=0.004; CI 95%); while on dorsal hand area of stratum corneum hydration (P=0.002; CI 95%). Centella asiatica topical gave significant improvement on palm area of stratum corneum hydration (P=0.007; CI 95%); while on dorsal hand area of stratum corneum hydration (P=0.001; CI 95%) and pH level (P=0.17; CI 95%). No significant differences of Aloe vera compared to Centella asiatica in the improvement of skin barrier function.
Drug Patch Test as a Diagnostic Test to Determine the Culprit Drug of Cutaneous Adverse Drug Reaction (CADR) Damayanti; Hari Sukanto; Marsudi Hutomo; Sylvia Anggraeni; Menul Ayu Umborowati; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15739

Abstract

Background: Cutaneous Adverse Drug Reaction (CADR) is a frequent problem in clinical practice since there were new drugs or drug misuse, which leads to high morbidity and mortality rate. It is often difficult to determine the offending drug only from the history. Provocation test, intradermal test or skin prick test are of significant value, but having higher risk to re-precipitate life-threatening reaction. Drug patch test (DPT) is a test, which is performed to CADR patient to determine the culprit drug. The main advantages of DPT are, it gives rarely adverse reaction and any commercialized form of drugs can be used.Methods: This is a retrospective study, aimed to analize the clinical relevance between anamnesis and DPT result in patient with history of CADR. All patient, who were performed with DPT in one year period in Dr. Soetomo General Academic Hospital Surabaya Indonesia, were evaluated in this study. Results: There were 14 patients with history of CADR, who performed DPT; consist of 7 maculopapular eruption cases, 4 Stevens-Johnson Syndrome (SJS) cases, 1 Fixed Drug Eruption (FDE) case, 1 Acute Generalized Exanthematous Pustulosis (AGEP) case and 1 Drug Reaction with Eosinophilia and Systemic Reaction (DRESS) case. There were 9 patients (64.3 %), who got positive result of DPT. The relevance between anamnesis and positive result of DPT were shown in 8 patient (88.9%) of 9 patient with positive DPT result. Conclusion: DPT has important role in identifying the culprit drug in CADR, especially when multiple drugs are involved.
The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis Sylvia Anggraeni; Menul Ayu Umborowati; Damayanti; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15965

Abstract

Background: Skin Prick Test (SPT) is good diagnostic tool of allergic disease such as Atopic Dermatitis (AD). Imported allergen extracts are expensive and not always available in Indonesia. New local SPT allergen extracts are potential as substitute. Objective: To compare SPT results of new local and imported allergen extracts (house dust mite, chicken, egg white, cow’s milk, and shrimp), and specific IgE in AD patients. Methods: This was clinical trial of 45 non lesional AD patients. The SPT of imported allergen extracts was performed in the first week, followed by the new local and specific IgE examination in the next one week. Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between 15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local extracts (86.4%; 84.4%). Conclusion: New local allergen extracts should be considered as a substitute of the imported diagnostic tool.
Co-Authors Agatha Anindhita Ayu Ardhaninggar Anang Endaryanto Cita Rosita Sigit Prakoeswa Damayanti Dwi Murtiastutik Hari Sukanto Irmadita Citrashanty Marsoedi Hoetomo Marsudi Hutomo Maylita Sari Rahmadewi Rahmadewi Riyana Noor Oktaviyanti Sawitri Sawitri Sri Awalia Febriana Sylvia Anggraeni Sylvia Anggraeni2