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UJI EFEKTIVITAS NYERI EKSTRAK ETANOL BIJI MAHONI (Swietenia mahagoni) TERHADAP MENCIT JANTAN (Mus musculus) YANG DI INDUKSI ASAM ASETAT 1%. Farid, Nurfiddin; Wahid, Hilmiati; Aliah, Ahmad Irsyad
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 2 (2021): Agustus, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i2.214

Abstract

Nyeri adalah perasaan sensorik dan emosional yang tidak nyaman, berkaitan dengan adanya kerusakan jaringan. Biji mahoni (Swietenia mahagoni), mengandung senyawa flavanoid yang mampu memberikan efek analgetik dengan menghambat biosintesis prostaglandin sehingga mengurangi rasa nyeri, penelitian ini bertujuan untuk mengetahui aktivitas analalgetik ekstrak etanol biji mahoni (Swierenia mahagoni) pada mencit jantan (Mus musculus) yang di induksi asam asetat 1%. Penelitian yang dilakukan adalah penelitian eksperimental dengan desain penelitian Posttest Only Control Group Design. Hewan uji dibagi menjadi tiga kelompok, masing-masing perlakuan terdiri dari lima ekor mencit jantan (Mus musculus) dengan pemberian kontrol yang berbeda-beda, Mencit 1 (Na CMC 0,5% kontrol negatif), mencit 2 (Ekstrak etanol biji mahoni dosis 100mg), mencit 3 (Ekstrak etanol biji mahoni dosis 200mg), mencit 4 (Ekstrak etanol biji mahoni dosis 400mg) dan mencit 5 (Ibuprofen 400mg kontrol positif). Hasil penelitian yang diperoleh ekstrak biji mahoni memiliki khasiat sebagai analgetik pada dosis 100mg 37,79%, dosis 200mg 57,40% dan ekstrak etanol biji mahoni dosis 400mg 70,80%. Hasil terbaik diperoleh pada konsentrasi 400mg yaitu 70,80%, semakin tinggi dosis ekstrak biji mahoni (Swietenia mahagoni) semakin besar pula daya analgetiknya.Kata Kunci:  Nyeri, analgetik, biji mahoni, Flavonoid. 
Identifikasi Extended Spectrum Beta Laktamase (ESBL) Antibiotika Golongan Sefalosporin pada Bakteri Acinetobacter baumannii Wahid, Hilmiati
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.943 KB) | DOI: 10.25026/jsk.v2i4.188

Abstract

Extended Spectrum Beta-Lactamases (ESBL) are group of enzymes that break down the antibiotics of penicillin and cephalosporin group,this enzymes made bacteria are resistant to this type of antibiotic. Acinetobacter baumannii is one of the gram-negative bacteria, produce the ESBL enzyme. Globally, Acinetobacter baumannii has become a nosocomial pathogen that continues to increase in frequency. The prevalence of ESBL of Acinetobacter spp in Indonesia is 19-29% which is resistant to the third and fourth generation cephalosporin antibiotics. This study uses an experimental laboratory design with consecutive sampling techniques. Acinetobacter baumannii was isolated from 50 patients. The isolate comes from sputum, pus, blood, urine, endotrackeal (ETT), pleural fluid, bronchial rinses and stool. Samples of isolates were identified using standard bacteriological methods and the Vitek 2 Compact ® system using a GN card. Tests carried out include antimicrobial sensitivity tests performed using the Kirby-Bauer diffusion method and ESBL production test using the Double Disc Synergy Test (DDST) and Phenotypic Confirmatory Test. The results showed that the bacterium Acinetobacter baumannii was successfully isolated from all samples with an accuracy level (91% - 99%). In the antimicrobial sensitivity test it was found that of the 50 clinical samples tested against antibiotics cephalosporin group, which had experienced resistance in the largest sequence were Cefotaxime 22 samples (44%), Ceftazidime 20 samples (40%), Ceftriaxone 20 samples (40%) and Cefepime 19 samples (38%). In the ESBL production test found 9 samples (18%) positive ESBL in ceftazidime + As.Klavulanat antibiotics, 9 samples (18%) positive ESBL in cefotaxime + As.Klavulanat antibiotics (30 ?g / 10 ?g). Keywords: Cephalosporin antibiotics, Acinetobacter baumannii, Resistance, Extended Spectrum Beta Lactamase (ESBL)