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All Journal Jurnal Riset Kefarmasian Indonesia Majalah Cendekia Mengabdi
Tampubolon, Antetti
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Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Jurnal Riset Kefarmasian Indonesia

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PENGARUH PENAMBAHAN POLIETILEN GLIKOL 6000 PADA TABLET IBUPROFEN DISPERSI PADAT TERHADAP ABSORBSI IBUPROFEN SECARA IN SITU Tampubolon, Antetti
Jurnal Riset Kefarmasian Indonesia Vol 3 No 3 (2021): Jurnal Riset Kefarmasin Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i3.167

Abstract

Drug absorption can be decided by various methods, namely in vitro methods, in situ methods, and in vivo methods. The in situ method is a procedure that is very close to the in vivo method. The aim of this study was to identify the effect of accumulation of polyethylene glycol 6000 (PEG 6000) on solid dispersion of ibuprofen tablets on the in-situ absorption of the drug. This research was conducted through an experiment to determine the effect of adding polyethylene glycol 6000 to the absorption of ibuprofen in situ by flowing the solution from solid dispersion ibuprofen tablets, solutions from generic ibuprofen tablets and standard ibuprofen solutions. The solid dispersion system was carried out by melting ibuprofen and polyethylene glycol 6000 in a ratio of 1:05. The drug solution was flowed through the lumen of the small intestine of male rats. Unabsorbed ibuprofen was measured by an ultraviolet spectrophotometer at a wavelength of 225.5 nm. Next, the absorbed level of ibuprofen was calculated. The results showed that ibuprofen from solid dispersion tablets was absorbed more than ibuprofen from generic tablets and standard ibuprofen. It can be concluded that polyethylene glycol 6000 has an effect on the absorption of ibuprofen in situ.
Co-Authors Adhisty Nurpermatasari Ahmad Purnawarman Faisal amrin Andarwati, Rini Ernoviya, Ernoviya Fauzi, Zulfa Ismaniar Hilda Ismedsyah Lavinur Masniah Masniah Masrah Nadroh br Sitepu Nasution, Samihah Noviar, Irma NURUL HIDAYAH Panjaitan, Rosnike Merly Pratiwi Rukmana Nasution Sihombing, Jhonson P Sinaga, Maya Handayani Tanjung, Sri Wahyuni Wakidi, Riza Fahlevi Wulandari, Mimin yusnita, henny Zulfikri