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All Journal INDONESIAN JOURNAL OF PHARMACY
T, Thirunala Sundari
Dept. of Biotechnology, Bharathidasan University, Tiruchirapalli, Tamil Nadu, 620 024, India.
Medicine & Pharmacology

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EVALUATION OF ANTIMICROBIAL POTENTIALS OF Cardiospermum halicacabum Linn. Veerappan, Loganathan; T, Thirunala Sundari; N, Pradheepa
Indonesian Journal of Pharmacy Vol 24 No 1, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.272 KB) | DOI: 10.14499/indonesianjpharm24iss1pp61-64

Abstract

Antimicrobial activity of Cardiospermum halicacabum shoot extracts were studied on gram-positive bacteria such as Staphylococcus aureus, Bacillus substilis, and gram-negative bacteria such as E.coli, Proteus vulgaris, and fungus Candida albicans. Disc diffusion method was used to study the antimicrobial activity of aqueous, ethanol, chloroform and ether extracts of C. halicacabum. Ampicillin was used as reference standard at 10 mg/disc concentration. Extracts of C. halicacabum exhibited a significant antibacterial activity except the aqueous extract. Ethanolic extract was found to be very effective with maximum activity index (0.84). The ethanolic extract exhibited minimum inhibitory concentration (MIC of 0.25 mg/mL against Staphylococcus aureus, Bacillus substilis, E. coli and Proteus vulgaris and 0.125 mg/mL against Candida albicans. The MIC of chloroform and ether extracts ranged between 0.25 and 1.0 mg/ml against the test organisms. All the extracts showed antifungal activity against Candida albicans. Key words: antimicrobial activity, Cardiospermum halicacabum shoot system, solvent extraction,.
Co-Authors N, Pradheepa Veerappan, Loganathan