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All Journal INDONESIAN JOURNAL OF PHARMACY
Wahyono, Djoko
Department Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Indonesia
Medicine & Pharmacology

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The effect of pretreatment of Broccoli (Brassica oleracea L. var. botrytis L.) to rifampicin pharmacokinetics in rats Wahyono, Djoko; Hakim, Arief Rahman
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.215 KB) | DOI: 10.14499/indonesianjpharm0iss0pp177-181

Abstract

Consuming the meal during drug therapy could influence on pharmacokinetics profile of the drugs. The research was aimed to observe broccoli (Brassica oleracea L. var. botrytis L.) activities to rifampicin pharmacokinetics in rats. The study of interaction broccoli with rifampicin pharmacokinetics was conducted employing a completely randomaized design using female Sprague Dawley rats which were divided into 3 groups (6 rats for each group). The results have shown that the pharmacokinetics values of rifampicin in the animals prefed with broccoli 23.43 mg/kg BW 1 hours prior to single oral administration of the drug (P-II) did not change significantly (P>0.10). Prefeeding the animals with broccoli 23.43 g/kg BW once daily for 7 consecutive days (P-I) has increased the total clearance of rifampicin 46.90% (P
Co-Authors Yundari, Yundari