Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal INDONESIAN JOURNAL OF PHARMACY
Suruse, Pravin Babarao
Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, (MS), India.
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF DOMPERIDONE MALEATE Dixit, Yuwaraj Dilipsingh; Suruse, Pravin Babarao; Shivhare, Umesh Dhaniram
Indonesian Journal of Pharmacy Vol 24 No 1, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.083 KB) | DOI: 10.14499/indonesianjpharm24iss1pp47-55

Abstract

The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperidone maleate. It is an antiemetic synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Mucoadhesive Domperidone maleate tablet formulation was prepared by direct compression method. The formulation F3 containing (Carbopol 940 + sodium alginate) was found to be best among all the formulation batches because of its consistent release rate for 7 h and extent of drug release was 94.44%. Graphical treatment of the formulation F3 to Higuchi’s equation showed that the drug release was diffusion mediated. In-vitro permeability study for formulation F3 for 7 h had shown 76.69% drug release. FTIR studies showed no evidence on interaction between drug and polymers. Key words: Domperidone maleate, Mucoadhesive tablet, antiemetic
Co-Authors Dixit, Yuwaraj Dilipsingh Shivhare, Umesh Dhaniram