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All Journal INDONESIAN JOURNAL OF PHARMACY
Sahoo, Nalini Kanta
MNR College of Pharmacy, Fasalwadi, Sangareddy, Medak, Telangana, 502294,India
Medicine & Pharmacology

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FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF GRANISETRON HYDROCHLORIDE USING PLANTAGO OVATE AS NATURAL SUPERDISINTEGRANTS Sahoo, Chinmaya Keshari; Sahoo, Nalini Kanta; Sahu, Madushima; ., V.Alagarsamy; Moharana, Alok Kumar; Sarangi, Deepak Kumar; Satyanarayana, Kokkula
Indonesian Journal of Pharmacy Vol 27 No 1, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (856.669 KB) | DOI: 10.14499/indonesianjpharm27iss1pp35

Abstract

The main objective of the study was to develop orodispersible tablets of Granisetron hydrochloride, a selective 5-HT3 receptor antagonist (an antivomiting agent) for improving patient compliance, especially those of paediatric & geriatric categories with difficulties in swallowing. In the wet granulation method orodispersible (ORD) tablets were prepared using natural super disintegrants  plantago ovate.The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, in vitro dispersion time, drug content and in vitro dissolution studies. The tablet formulation batch F4 was considered as the overall best formulation (with an in vitro drug release study of 99.11%).Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there no significant changes in drug content. From the Fourier Transform Infrared (FTIR) spectroscopy study indicated that there are no drug excipient interactions. Key words:  Granisetron hydrochloride, Orodispersible tablets, FTIR spectroscopy, in vitro drug release study.
Co-Authors ., V.Alagarsamy Moharana, Alok Kumar Sahoo, Chinmaya Keshari Sahu, Madushima Sarangi, Deepak Kumar Satyanarayana, Kokkula