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Maleachi, Reginald
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pencegahan Efek Radiasi pada Pencitraan Radiologi Maleachi, Reginald; Tjakraatmadja, Ricardo
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.811 KB) | DOI: 10.55175/cdk.v45i7.647

Abstract

Efek radiasi dalam bidang radiologi tidak dapat dihindari. Ahli radiologi perlu berhati-hati terhadap bahaya dan efek radiasi, mengetahui batasan dosis radiasi yang aman, cara meminimalkan paparan radiasi, dosis terkecil untuk visualisasi pencitraan yang baik. Keselamatan pasien dan petugas medis perlu mendapat perhatian khusus. Proteksi radiasi penting untuk pasien, staf, serta ahli radiologi sendiri dengan cara menaati indikasi pemeriksaan yang tepat, jumlah pemeriksaan seminimal mungkin, dan sedapat mungkin memilih modalitas pencitraan yang tidak memerlukan radiasi.The effects of radiation in radiology can not be avoided. Radiologists should be cautious, know the limit of radiation dose, minimize radiation exposure, and to get the best visualization image with minimal dose. Safety of patients and medical staffs need special attention. Radiation protection is important for patients, staffs, and radiologists through proper indications, minimizing examinations, and to prioritize non-radiation imaging modalities.
Bone metastases tend to increase in non-small cell lung cancer with epidermal growth factor receptor mutation Maleachi, Reginald; Erawati, Dini Rachma; Pratiwi, Suryanti Dwi; Andarini, Sri
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.4-10

Abstract

BackgroundIncreased understanding in molecular pathology of advanced non-small cell lung cancer (NSCLC) over the past decades has led to personalized treatment approaches being advocated. Epidermal growth factor receptor (EGFR) mutation that often occurs in NSCLC can be identified using immunohistochemical examinations. Moreover, clarifying the relationship between computed tomography (CT) and EGFR mutation of NSCLC might inform therapeutic decision-making. The purpose of this study was to determine the relationship between metastatic sites on primary chest CT-scan and EGFR mutation in NSCLC lung cancer patients. MethodsAn cross-sectional design using secondary data was conducted, involving 76 NSCLC patients. EGFR mutations were determined by immunohistochemical examination and metastatic sites by chest CT-scan with contrast. The collected metastatic sites comprised hilar and mediastinal lymphadenopathy, pulmonary nodules, and bone, liver, spleen and suprarenal metastases. A Chi square test was used to analyze the data. ResultsThis study revealed that the highest NSCLC stage was IVb, found in 39 samples (51.3%), while 34 (44.7%) subjects had EGFR mutation. There was no statistically significant difference between metastatic site and positive EGFR mutation, although positive bone metastases (54.8%) tend to have more numerous positive EGFR mutations compared to negative bone metastases (37.7%) (p=0.142). ConclusionsPatients with positive bone metastases tend to have higher positive EGFR mutation compared to negative bone metastases in NSCLC lung cancer patients. Prospective studies evaluating patients with EGFR mutation for bone metastases should be considered. This can provide information on therapeutic decision-making to obtain good clinical outcomes.
Co-Authors Erawati, Dini Rachma Pratiwi, Suryanti Dwi Sri Andarini Tjakraatmadja, Ricardo