Lim, Zack ST.
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Cancer Immunotherapy and CAR T Cells Ong, Khing S.; Lim, Zack ST.; Setiawan, Boenjamin
Cermin Dunia Kedokteran Vol 45, No 12 (2018): Farmakologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.278 KB) | DOI: 10.55175/cdk.v45i12.551

Abstract

Within the past decade, radical changes of idea emerged from the works of research scientists, medical experts and oncologists. Instead of treating cancers with man-made chemicals or chemotherapy and radiotherapy, or surgically remove the tumor, we should unleash the power of our own body immune system. Indeed, such approach has borne fruits and benefited at least for some cancer patients. This review described various types of immunotherapy known to date, with its beneficial effects, albeit some with serious harmful effects. To understand how immunotherapies worked, we also review some biologic characteristic of cancer cell that let them evade attacks from our immune system; cancer microenvironment that works in favor or protecting the growth of cancer against our immune system will also be discussed.Hanya dalam jangka 10 tahun terakhir, telah terjadi perubahan radikal hasil penelitian penyakit kanker. Di samping cara klasik penyembuhan kanker seperti obat-obat kimia sintetik, kemoterapi dan radiologi atau pembedahan, kini para ahli telah menggunakan sistim imunitas tubuh penderita sendiri. Cara ini telah terbukti dalam pengobatan beberapa pasien kanker. Dalam ulasan ini kami akan memaparkan beberapa immunoterapi saat ini dengan hasil baik meskipun masih terdapat beberapa kesalahan dan efek samping. Akan diulas dan dijelaskan sifat-sifat biologi sel kanker, dan bagaimana kanker sel bisa menghindari serangan sistim imun; dan lingkungan mikrokanker (cancer microenviroment) yang melindungi kanker dari sistim imun.Â