Bianti, Marsha
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Kulit Kering pada Usia Lanjut Bianti, Marsha
Cermin Dunia Kedokteran Vol 43, No 10 (2016): Anti-aging
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.897 KB) | DOI: 10.55175/cdk.v43i10.871

Abstract

Penyakit kulit sangat jarang mengancam nyawa, namun dapat menimbulkan hendaya bagi penderitanya. Proses penuaan menyebabkan perubahan fisiologis, termasuk kulit kering. Pada kulit usia lanjut terjadi penipisan epidermis, penurunan suplai darah, cairan, dan nutrisi ke kulit, melambatnya penyembuhan luka dan respon imun, terganggunya termoregulasi dan berkurangnya jumlah kelenjar minyak dan keringat. Di tingkat selular, terjadi penurunan produksi lipid dan natural moisturizing factor di stratum korneum. Selain itu, pada usia lanjut sering terdapat penyakit-penyakit komorbid yang mempengaruhi penurunan fungsi kulit.. Kulit kering atau xerosis cutis dapat menyebabkan pruritus dan terganggunya kualitas hidup penderita, khususnya usia lanjut. Oleh karena itu, diperlukan pendekatan dan tatalaksana holistik untuk mengatasi kulit kering pada usia lanjut.Skin disorders are rarely considered as life-threatening condition, however it may cause disabilities. Aging may cause physiological changes in skin; there will be decreased skin thickness, reduced blood and nutrition supplies, delayed wound healing and immune response, impaired thermoregulation, and atrophy of sebaceous and sweat glands. In cellular level, lipid and natural moisturizing factor production in stratum corneum will be reduced, resulting in dry skin. The comorbidities may further impaired skin function. Dry skin or xerosis cutis may cause pruritus and impairment in patients’ quality of life, especially in elderly. Holistic approach and treatment are needed to manage dry skin in elderly.
Efficacy of Topical Estradiol Compared to Topical Glycolic Acid for Skin Aging Treatment in Postmenopausal Women Yusharyahya, Shannaz Nada; Bianti, Marsha
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Skin aging is a complex biological process in human being, as a result from intrinsic factors (genetic, hormonal, metabolism) and extrinsic factors (UV exposure, pollution, smoking, life style). In postmenopausal women, physiologically, the amount of estrogen are decreased, causing deterioration of their skin’s appearance. Along with the changes that occur, skin care require more attention. A holistic approach can increase epidermal thickness, therefore, reducing the depth of wrinkles, as well as improving skin texture and moisture. There are various treatments available to improve skin appearance due to aging. This EBCR is aimed to compare the efficacy of topical estradiol and topical glycolic acid as skin treatment in postmenopausal women. Articles were searched through Pubmed/MEDLINE, EBSCO, and Cochrane. One randomized-controlled trial by Fuchs KO, et al was obtained and critically appraised. Based on the appraisal, study by Fuchs KO, et al is considered valid, important, and applicable. Both estradiol and glycolic acid show good efficacy and safety for postmenopausal women with signs of skin aging, however estradiol is not considered to have better efficacy than glycolic acid.
Comparison of efficacy combination oral terbinafine pulse-dosed and topical 8% ciclopirox olamine with terbinafine monotherapy for onychomycosis: An evidence-based case report Bianti, Marsha; Nuary, Teffy; Widaty, Sandra
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Onychomycosis is a fungal infection of the nails, which manifested as nail discoloration, thickening, and detachment from the nail bed. It is not life-threatening, however inappropriate treatment of onychomycosis might lead to complications and affect the patient’s quality of life; making the management of the disease a challenge for clinicians. Objective: Investigate the efficacy of pulse-dosed oral terbinafine combined with topical 8% ciclopirox olamine to treat onychomycosis. Methods: Literature search was performed in Pubmed and Cochrane databases using the keywords 'combination' AND 'oral terbinafine' AND 'ciclopirox' AND ‘onychomycosis treatment’ along with their synonyms and related terms. Results and Discussion: After critical appraisal, studies by Avner et al. and Jaiswal et al. found to be valid, important, and applicable to the patient. The first study found that oral terbinafine combined with topical 8% ciclopirox olamine is more effective and safe compared to terbinafine as a monotherapy (p<0.05). The second study found similar results, but without statistical significance (p>0.05). Conclusions: Oral terbinafine combined with topical 8% ciclopirox olamine is more effective than monotherapy, despite statistical irrelevance in one of the studies appraised. Further studies are needed to support the implementation of combination therapy.
Efficacy of low level laser therapy in the treatment of postherpetic neuralgia Legiawati, Lili; Bianti, Marsha
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Background: Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ) and defined as pain that persists for more than 90 days after the onset of HZ rash. The chronic pain of PHN is debilitating and often associated with significant morbidity. It is a neuropathic pain and manifests as allodynia, hyperalgesia, or spontaneous pain. Although it is not considered to be life-threatening, sometime HZ is inadequately treated and may result in more severe PHN. Various treatment protocols for PHN are available; however, the result remains unsatisfactorily. The use of low level laser therapy (LLLT) in pain management is relatively new and is used with increasing frequency in the management of chronic pain. Aim: To assess the efficacy of low level laser therapy in the treatment of postherpetic neuralgia. Methods: Articles were searched through Pubmed/ MEDLINE, Cochrane, and Google scholar. Two randomized-controlled trials by Kemmotsu et al. and Moore et al. were obtained and critically appraised. Results: Based on the appraisal, studies by Kemmotsu et al. and Moore et al. are considered valid, important, and applicable. The results demonstrated a significant reduction in PHN intensity following a course of LLLT (p< 0.05). Conclusion: There is a statistically significant difference between the involvement of LLLT in PHN patients and without involvement of LLLT. LLLT is a noninvasive, painless, and safe method of treatment and may be recommended as an early intervention for pain therapy of PHN.
Efficacy and safety of 5% imiquimod cream compared to 10% KOH solution for elimination of molluscum contagiosum lesions in adults Bianti, Marsha; Rheza, Agung Muhammad; Marina, Arinda; Hilma, Rizka Farah; Mahri, Sarah; Nuary, Teffy; Rihatmadja, Rahadi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Molluscum contagiosum (MC) is a benign infection caused by the Molluscipox virus that most often affects children and sexually active adolescents. Various topical therapeutic options are available, however, no single intervention is convincingly effective. Potassium hydroxide (KOH) solution is widely used but its usefulness is hampered with adverse effects. Newer preparation, 5% imiquimod cream seems to be as, if not more, effective. However, it is not legally available yet in Indonesia. Aim: To assess the efficacy and safety of 5% imiquimod cream in treating adult molluscum contagiosum. Methods: Literature search was done through Pubmed, EBSCO, dan Cochrane databases. Inclusion criteria included articles in English, available in free full text and matched with the clinical question as well as providing the clinical outcome of papules clearance within 12 weeks. Results: There were three articles found to be related to the clinical question and they were critically appraised for their validity, importance, and applicability. Conclusion: Only two studies were valid and further assessed for their importance and applicability. In regards to importance, imiquimod has fewer side effects than KOH, yet it was not constantly shown to be superior to KOH in curing MC lesions. We conclude that KOH solution is the preferred treatment of MC in adults.