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All Journal Indonesian Journal of Pharmaceutical Science and Technology FITOFARMAKA: Jurnal Ilmiah Farmasi Menara Perkebunan
Tri Aminingsih
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Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Medicine & Pharmacology

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Formulation of Instant Granule Containing Nano Calcium from the Shell of Freshwater Mussels (Anodonta woodiana) for Autism Children Aminingsih, Tri; Srie Rahayu, Sata Yoshida; Yulianita, Yulianita
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.738 KB) | DOI: 10.15416/ijpst.v1i1.16125

Abstract

The small particle size of nano calcium from freshwater mussels shell will tend to increase the absorp- tion of calcium by human’s body and will be very well consumed by children with special needs to suppress hyperactivity disorders that caused by mercury. This study aimed to create and determine the best instant granule formulation containing nano calcium from freshwater mussels shell. The research method began with the manufacture of freshwater mussels shell powder and isolated nano calcium. Nano calcium was tested for its solubility in acid. The granule formula was made with stevia varia- tions. Instant granule evaluation included granule ow test, rest angle, compressibility, water content, solubility, hedonic test, and calcium bioavailability. The results showed that nano calcium was soluble in 1:1 ratio of citric and tartrate acids, so that each formula needs 1.2% citric and 1.2% tartrate acids. Based on the avor, aroma, and texture, the most preferred granule formula contained 600 mg nano calcium, 60 mg citric acid, 60 mg tartaric acid, 400 mg stevia each sachet weighing 5 g. The best in- stant granule evaluation showed that the ow rate was 4.253 g/sec, 33.90 rest angle, 4.65% compress- ibility, 2.21% water content, soluble time 58 second and calcium bioavailability was 100%. Key words: Calcium bioavailability, detoxi cation, freshwater mussels, instant granule, nano cal- cium.
Co-Authors Firda DIMAWARNITA Irma KRESNAWATY Mira Miranti Nashrianto, Husain SATA YOSHIDA SRIE RAHAYU Susy SAADAH Syaiful Rohman, Aji Tri Panji Yulianita, Yulianita