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HUBUNGAN USIA DENGAN DERAJAT DIFERENSIASI KANKER PAYUDARA PADA WANITA Hasfira, Fairuz Izdihar; Oktaviyanti, Ika Kustiyah; Budiwinata, Winardi; Priyono, Sasongko Hadi; Rosida, Lena
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13219

Abstract

Abstract: Breast cancer is a type of cancer that starts in the breast tissue and spreads to the duct or lobule epithelium. As people age, the incidence of breast cancer rises. The aim of this research is to determine the correlation between age and the level of breast cancer differentiation in female patients at RSUD Ulin Banjarmasin. This study used a cross-sectional technique and an analytical observational research design. Purposive sampling was the method used to collect the samples. A total of 64 breast cancer slides met the inclusion criteria for the sample size. A 95% confidence level was used to evaluate the relationship between the two variables using the chi-square test. People under the age of 40 received grade 1 (8.7%), grade 2 (39.1%) and grade 3 (52.2%), while people beyond the age of 40 received grade 1 (14.6%), grade 2 (63.4%), and grade 3 (22%). The chi-square statistical results suggest p-value=0,047. The results showed a correlation between a woman's age and the degree of breast cancer differentiation at RSUD Ulin Banjarmasin. Keywords: breast cancer, grade, age  Abstrak: Kanker payudara ialah suatu keganasan pada jaringan payudara yang berasal dari epitel duktus ataupun lobulus. Insiden dari kanker payudara meningkat sejalan dengan bertambahnya usia. Derajat diferensiasi ialah ukuran perbandingan sel kanker dengan sel normal yang membantu dalam memprediksi prognosis. Penelitian ini memiliki tujuan untuk mengetahui apakah adanya hubungan antara usia dengan derajat diferensiasi kanker payudara pada wanita. Penelitian ini memakai rancangan penelitian observasional analitik melalui pendekatan cross sectional. Sampel diambil melalui teknik purposive sampling. Sampel yang memenuhi inklusi ialah 64 slide kanker payudara. Hubungan dari kedua variabel dianalisis menggunakan uji chi-square dengan tingkat kepercayaan 95%. Usia ≤40 tahun didapatkan grade 1 (8,7%), grade 2 (39,1%), dan grade 3 (52,2%), sedangkan usia >40 tahun didapatkan grade 1 (14,6%), grade 2 (63,4%), dan grade 3 (22%). Hasil dari statistik chi-square menunjukkan p-value=0,047. Penelitian ini mendapatkan hasil bahwa adanya hubungan antara usia dengan derajat diferensiasi kanker payudara pada wanita di RSUD Ulin Banjarmasin. Kata-kata kunci: kanker payudara, derajat diferensiasi, usia
HUBUNGAN FAKTOR PREDISPOSISI DENGAN KETERLAMBATAN BEROBAT PASIEN KANKER PAYUDARA LANJUT LOKAL Juliana, Adies; Budiwinata, Winardi; Oktaviyanti, Ika Kustiyah
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13175

Abstract

Abstract: Breast cancer patients often come to the doctor diagnosed at a locally advanced stage. The cause of delay in treatment is influenced by predisposing factors, namely knowledge, family history, education level, attitude, action to seek health facilities, fear, and family income. The study aimed to analyze the relationship between predisposing factors and the delay in treatment of locally advanced breast cancer patients. The study used an analytic observational method with a cross sectional approach. The study respondents were 51 patients with locally advanced breast cancer who sought treatment at the Oncology Surgery Polyclinic and were recorded in the medical records of RSUD Ulin Banjarmasin for the period January 2020-November 2023. Data were collected based on a questionnaire of predisposing factors for delay in treatment. Data analysis used Fisher's test on SPSS and was said to have a significant relationship if p < 0.05. As a result, the majority of respondents were in the inoperable category 96.1% with poor knowledge (84.3%; p=0.022), low education level (51%; p=1), no family history (56.9%; p=0.5), poor attitude (92.2%; p=0.152), poor action to seek health facilities (90.2%; p=0.188), fear of symptoms (82.4%; p=0.152), and low family income (60.8%; p=1). In conclusion, there was a significant association between knowledge and delay in seeking treatment for locally advanced breast cancer patients. Meanwhile, the level of education, family history, attitude, action to seek health facilities, fear and family income did not have a significant relationship with the delay in treatment of locally advanced breast cancer patients. Keywords: breast cancer, locally advanced, predisposing factor, treatment delay Abstrak: Pasien kanker payudara seringkali datang ke dokter terdiagnosis pada stadium lanjut lokal. Penyebab keterlambatan berobat tersebut dipengaruhi oleh faktor predisposisi, yaitu pengetahuan, riwayat keluarga, tingkat pendidikan, sikap, tindakan mencari fasilitas kesehatan, rasa takut, dan penghasilan keluarga. Penelitian bertujuan menganalisis hubungan faktor predisposisi dengan keterlambatan berobat pasien kanker payudara lanjut lokal. Penelitian menggunakan metode observasional analitik dengan pendekatan cross sectional. Responden penelitian adalah 51 pasien kanker payudara lanjut lokal yang berobat ke Poliklinik Bedah Onkologi dan terdata di rekam medis RSUD Ulin Banjarmasin periode Januari 2020-November 2023. Data dikumpulkan berdasarkan kuesioner dan analisis data menggunakan uji Fisher pada SPSS, dikatakan memiliki hubungan signifikan apabila p < 0,05. Hasilnya, mayoritas responden dalam kategori inoperable 96,1% dengan pengetahuan kurang (84,3%; p=0,022) tingkat pendidikan rendah (51%; p=1), tidak memiliki riwayat keluarga (56,9%; p=0,5), sikap kurang (92,2%; p=0,152), tindakan mencari fasilitas kesehatan kurang (90,2%; p=0,188), takut gejala (82,4%; p=0,152), dan penghasilan keluarga rendah (60,8%; p=1). Kesimpulannya, terdapat hubungan signifikan antara pengetahuan dengan keterlambatan berobat pasien kanker payudara lanjut lokal. Aspek tingkat pendidikan, riwayat keluarga, sikap, tindakan mencari fasilitas kesehatan, rasa takut dan penghasilan keluarga tidak terdapat hubungan signifikan dengan keterlambatan berobat pasien kanker payudara lanjut lokal. Kata-kata kunci: kanker payudara, stadium lanjut lokal, faktor predisposisi, keterlambatan berobat
HUBUNGAN DERAJAT DIFERENSIASI DENGAN JUMLAH SEL RADANG LIMFOSIT PADA HISTOPATOLOGI KANKER KOLOREKTAL Wahyuni, Dina; Wibowo, Agung Ary; Oktaviyanti, Ika Kustiyah; Budiwinata, Winardi; Rosida, Lena
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11450

Abstract

Colorectal cancer is the third most common cause of death in the world. Colorectal cancer was ranked third in Indonesia. Colorectal cancer patients had a statistically significant difference in lymphocyte inflammatory cell values compared to healthy controls. Colorectal cancer patients had much higher lymphocyte inflammatory cell values than healthy controls. Lymphocyte infiltration can provide additional prognostic information for treatment options in some situations. Histopathology is an essential factor in determining the diagnosis, treatment management, and prognosis. Histopathological examination of the degree of differentiation can determine whether a neoplasm is malignant. The prognosis of colorectal cancer depends on the presence or absence of metastases and the degree of differentiation; with a histopathological examination, we can see the spread of inflammatory cell infiltration at the degree of differentiation which can be used to determine the prognosis of colorectal cancer. The normality test results of the p-value of inflammatory lymphocyte cells were <0.001. Correlation data analysis using the rank-spearman test showed p>0.05 in colorectal cancer patients at Ulin Hospital Banjarmasin.