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All Journal e-Journal Pustaka Kesehatan Dentika Dental Journal STOMATOGNATIC- Jurnal Kedokteran Gigi
Hengky Bowo Ardhiyanto
Fakultas Kedokteran Gigi Universitas Jember
Dentistry Health Professions Library & Information Science Medicine & Pharmacology

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PERAN HIDROKSIAPATIT SEBAGAI MATERIAL BONE GRAFT DALAM MENSTIMULASI KEPADATAN KOLAGEN TIPE L PADA PROSES PENYEMBUHAN TULANG Ardhiyanto, Hengky Bowo
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 1 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Bone has natural repair mechanism, but there are some critical sized defects which the tissues will not regenerate themselves and need clinical repair. Hydroxyapatite, as a popular bone substitute material, can be synthesized from nature. Recently, ceramic materials like hydroxyapatite have received much attention from both researchers and surgeons because of their biocompatibility, good mechanical properties and easy handling. Moreover, many have shown bio-absorbable properties compatible with those of various surgical applications permitting the complete bone regeneration and avoiding further interventions to remove the device. The conclusion is hydroxyapatite was affects for density of type l collagen in bone healing process.
STIMULASI OSTEOBLAS OLEH HIDROKSIAPATIT SEBAGAI MATERIAL BONE GRAFT PADA PROSES PENYEMBUHAN TULANG Ardhiyanto, Hengky Bowo
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Bone has natural repair mechanism, but there are some critical sized defects which will not allow the tissues to regenerate themselves. The clinical success of bone graft is dependent on the formation of an intimate contact between the material surface and mineralized tissue. Osteoblast attachment, proliferation and differentiation must be optimized in order for the mineralization, necessary for this intimate contact to occur. One of the bioceramics are frequently used in biomedical applications as a bone graft is a hydroxyapatite. Hydroxyapatite is a popular bone substitute material. The composition of hydroxyapatite crystals have an overview identical to hydroxyapatite in bone. This material is biocompatible, osteoinductive and osteoconductive, thus hydroxyapatite can be a medium for osteoblast to growth and improve the bone healing process.
JUMLAH OSTEOBLAS PADA PROSES PENYEMBUHAN TULANG PASCA IMPLANTASI HIDROKSIAPATIT SINTESIS DARI KALSIT: NUMBER OF OSTEOBLAST IN BONE HEALING PROCESS AFTER IMPLANTATION OF SYNTHETIC HYDROXYAPATITE FROM CALCITE Hengky Bowo Ardhiyanto; Widowati Siswomihardjo; Tetiana Haniastuti
Dentika: Dental Journal Vol. 17 No. 2 (2012): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.367 KB) | DOI: 10.32734/dentika.v17i2.1766

Abstract

Tulang memiliki respons penyembuhan secara alami, namun defek yang besar seringkali menyebabkan tulang tidak dapatberegenerasi dengan baik. Hidroksiapatit (HA) adalah material pengganti tulang yang sudah sering digunakan sebagaibone graft. Material ini dapat disintesis dari berbagai sumber, antara lain dari batuan kalsit. Tujuan penelitian ini adalahuntuk mengetahui jumlah sel osteoblas pada proses penyembuhan tulang setelah diimplantasi dengan hidrosiapatit sintesisdari kalsit sebagai material bone graft. Limapuluh delapan ekor tikus Sprague dawley dibagi menjadi 3 kelompok.Kelompok pertama adalah tikus yang diimplantasi dengan HA kalsit, kelompok kedua adalah tikus yang diimplantasidengan HA 200, dan kelompok ketiga tidak mendapat perlakuan (kontrol). Defek dibuat pada kondilus tulang femurdengan ukuran yang sama (diameter 3mm dan kedalaman 3mm). Enam ekor tikus pada masing-masing kelompokdikorbankan pada hari ke-14, 28 dan 56. Spesimen kemudian diproses secara histologis dan diwarnai denganhematoksilin-eosin. Hasil penelitian menunjukkan jumlah sel osteoblas pada tikus yang diimplantasi dengan HA 200lebih tinggi jika dibandingkan dengan HA sintesis kalsit. Jumlah sel osteoblas pada tikus yang diimplantasi dengan HAsintesis kalsit lebih tinggi bila dibandingkan dengan kelompok kontrol, secara statistik tidak terdapat perbedaan yangbermakna jumlah osteoblas antar kelompok (p>0,05). Sebagai kesimpulan, implantasi HA sintesis dari kalsit sebagaibone graft dapat meningkatkan jumlah sel osteoblas pada proses penyembuhan tulang, namun peningkatannya tidakbermakna.
Potensi Ekstrak Teh Hijau (Camellia sinensis) Terhadap Peningkatan Jumlah Sel Fibroblas Soket Pasca Pencabutan Gigi pada Tikus Wistar (The Potency of Green Tea Extract [Camellia sinensis] Against Increase of Fibroblast Cells on Socket Post Tooth Extracti Pandika Agung Kurnia; Hengky Bowo Ardhiyanto; Suhartini .
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

In dentistry, tooth extraction is a frequent maintenance treatment. Thing to consider is healing process after extraction. Healing process consists of three phases, I.e. inflammation, fibroblastic and remodeling. Plants that are believed to accelerate wound healing is green tea. This study was aimed to look at the number of fibroblast cells after tooth extraction that was given by green tea extract (Camellia sinensis). This research was an experimental laboratory with the post-test only control group design. The samples were 24 male Wistar rats and divided into 2 groups: control group and treatment group. Each group was further divided into 3 subgroups, 3rd day, 5th day, 7th day . After extraction of left mandibular first molar tooth, rats in treatment group were given by green tea extract every day until they were decapitated according to appointed day. Tissue was histologically processed by HE staining. Count of fibroblast cells was done under a microscope on 3 field of views  with magnification 400x. Data were analyzed by using Independent T-test and it showed that on 3rd p=0,777, on 5th p=0,000, and on 7th p=0,048. Based on analysis, it could be concluded that the number of fibroblast cells in treatment group were more that in control group.   Keywords: fibroblasts, green tea extract, tooth extraction, wound healing.
PERAN HIDROKSIAPATIT SEBAGAI MATERIAL BONE GRAFT DALAM MENSTIMULASI KEPADATAN KOLAGEN TIPE L PADA PROSES PENYEMBUHAN TULANG Hengky Bowo Ardhiyanto
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 1 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bone has natural repair mechanism, but there are some critical sized defects which the tissues will not regenerate themselves and need clinical repair. Hydroxyapatite, as a popular bone substitute material, can be synthesized from nature. Recently, ceramic materials like hydroxyapatite have received much attention from both researchers and surgeons because of their biocompatibility, good mechanical properties and easy handling. Moreover, many have shown bio-absorbable properties compatible with those of various surgical applications permitting the complete bone regeneration and avoiding further interventions to remove the device. The conclusion is hydroxyapatite was affects for density of type l collagen in bone healing process.
STIMULASI OSTEOBLAS OLEH HIDROKSIAPATIT SEBAGAI MATERIAL BONE GRAFT PADA PROSES PENYEMBUHAN TULANG Hengky Bowo Ardhiyanto
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bone has natural repair mechanism, but there are some critical sized defects which will not allow the tissues to regenerate themselves. The clinical success of bone graft is dependent on the formation of an intimate contact between the material surface and mineralized tissue. Osteoblast attachment, proliferation and differentiation must be optimized in order for the mineralization, necessary for this intimate contact to occur. One of the bioceramics are frequently used in biomedical applications as a bone graft is a hydroxyapatite. Hydroxyapatite is a popular bone substitute material. The composition of hydroxyapatite crystals have an overview identical to hydroxyapatite in bone. This material is biocompatible, osteoinductive and osteoconductive, thus hydroxyapatite can be a medium for osteoblast to growth and improve the bone healing process.
Co-Authors Pandika Agung Kurnia Suhartini Suhartini Widowati Siswomihardjo