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All Journal Journal of General Procedural Dermatology and Venereology Indonesia Media Dermato-Venereologica Indonesiana
Evita Halim Effendi
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Health Professions Medicine & Pharmacology

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Indonesian clinical practice guidelines for systemic and biologic agents for adults with plaque psoriasis Endi Novianto; Windy Keumala Budianti; Eyleny Meisyah Fitri; Benny Effendi Wiryadi; Retno Widowati Soebaryo; Erdina H. D Pusponegoro; Evita Halim Effendi; Githa Rahmayunita; Anis Irawan; Cita R. S. Prakoeswa; Harijono Kariosentono; Shafira Anindya Purnawan; Arlha Aporia Debinta
Journal of General - Procedural Dermatology and Venereology Indonesia Vol 5, No 3 (2021): December 2021
Publisher : Universitas Indonesia

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Abstract

Background: In response to various biologic and non-biologic systemic agents available in Indonesia, proper and accredited treatment guidelines are required to ensure patient safety. Appropriate treatment is crucial and may affect remission time and morbidities. These guidelines were developed by the Indonesian Society of Dermatology and Venereology – Kelompok Studi Psoriasis Indonesia (INSDV-KSPI) to provide updated decision-making algorithms for the biologic and non-biologic systemic agents for the treatment of adult patients with plaque psoriasis.Methods: Experts from twelve institutions across Indonesia were involved in developing the guidelines. Subsequently, a focus group discussed various journals, researchable questions, eligibility criteria, and outcomes of various treatments options.Results: Modified evidence to decision framework of treatment choices were constructed to aid dermatovenerologists across Indonesia in making a clinical judgment on the size of treatment options of biologic and non-biologic systemic agents for psoriasis treatment in Indonesia.Conclusion: These clinical practice guidelines, accepted and acknowledged by the Indonesian Society of Dermatology and Venereology - Kelompok Studi Psoriasis Indonesia (INSDV-KSPI), have been developed to present the latest and concise evidence- and experience-based guideline targeted towards dermatovenereologists in Indonesia on the management of adult plaque psoriasis. Keywords: biologic agents, guidelines, Indonesian, psoriasis
TATA LAKSANA TERKINI PENYAKIT SINDROM STEVENS-JOHNSON (SSJ)/ NEKROLISIS EPIDERMAL TOKSIK (NET) Dina Kusumawardhani; Eyleny Meisyah Fitri; Windy Keumala Budianti; Endi Novianto; Evita Halim Effendi
Media Dermato-Venereologica Indonesiana Vol 50 No 1 (2023): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i1.291

Abstract

Sindrom Stevens-Johnson (SSJ) dan nekrolisis epidermal toksik (NET) merupakan penyakit yang mengancam nyawa, ditandai oleh adanya ruam dan lepuh yang nyeri, disertai lepasnya lapisan epidermis, atau ulkus pada mukosa mulut, mata, dan genital. SSJ/NET merupakan spektrum terberat dari reaksi efek simpang obat yang dimediasi imun, terutama oleh sel T, dan termasuk reaksi hipersensitivitas tipe IVc. SSJ dan NET adalah penyakit yang sama, dibedakan berdasarkan persentase permukaan kulit yang terlibat yaitu SSJ (<10%), SSJ/NET overlap (10%-30%), dan NET (>30%). SSJ/NET sering disertai keterlibatan multiorgan dengan rerata mortalitas 1-5% pada SSJ dan 25-35% pada NET. Tata laksana optimal SSJ/NET meliputi diagnosis dini, identifikasi dan penghentian obat tersangka, mempertimbangkan kemungkinan adanya infeksi sebagai pencetus, serta terapi suportif sedini mungkin. Terapi suportif yang dilakukan oleh tim multidisipilin merupakan tata laksana utama. Terapi suportif yang baik terbukti dapat memperbaiki kondisi klinis pasien. Rekomendasi penggunaan terapi sistemik berupa kortikosteroid, siklosporin, intravenous immunoglobulin (IVIg), plasmaferesis, dan terapi target, hingga saat ini sangat bervariasi karena belum terdapat bukti efikasi berdasarkan penelitian randomized controlled trial.
Co-Authors Anis Irawan Arlha Aporia Debinta Benny Effendi Wiryadi Cita R. S. Prakoeswa Dina Kusumawardhani Endi Novianto Erdina H. D Pusponegoro Eyleny Meisyah Fitri Githa Rahmayunita Harijono Kariosentono Retno Widowati Soebaryo Shafira Anindya Purnawan Windy Keumala Budianti Windy Keumala Budianti