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All Journal Indian Journal of Forensic Medicine & Toxicology
Diah Purwaningsari
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Public Health

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The Effect of Hypertension as a Comorbid Factor on the Length of Stay in Patients Undergoing Cholecystectomy Albertus Magnus Arya Abisatya; Diah Purwaningsari; Wahyu Prasasti Mutiadesi; Redemptus Yudadi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17915

Abstract

Background: One of the gold standard procedures for cholelithiasis is cholecystectomy. Cholecystectomyhas numerous variated Length of stay results relies upon every nation and medical clinic. Hypertensionis perhaps the most widely recognized comorbid factors and are thought to impact prolonged length ofstay.Aim of Research: To study the effect of hypertension as a comorbid factor on the length of stay in patientsundergoing cholecystectomy in Dr. Ramelan Naval Hospital Surabaya from June 2019-September 2020.Method of Research: This is an analytic descriptive research with retrospective study. The samplingtechnique used in this research is total sampling. The data were collected from medical record data ofpatients at the Internal Medicine and Digestive Surgery Polyclinic.Result of Research: The number of patients who underwent cholecystectomy with hypertensionwho underwent a length of stay > 5 days were 36 people (83.7%). The result from the CoefficientContingency test shows that there is a correlation between hypertension as a comorbid factor and thelength of stay (p<0,0001).Conclusion: This research shows that there is comorbidity such as hypertension affects the length ofstay in cholecystectomy.
Wild Strawberry Fragaria vesca L. extracts Hepatoprotective Activities Against Paracetamol-Induced Hepatotoxicity in Male Wistar Rats Sihning E. J. T; Diah Purwaningsari; Nita Pranitasari; Liliawanti
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17995

Abstract

Background: Administration of high-dose paracetamol had been indicated to induce several molecular and biochemical cascades of hepatotoxicity. The abundant amount of ROS formation following the uptake of the medication exceeds the physiologic antioxidant capacity of the body, leading to the occurrence of oxidative stress. Wild strawberries (Fragaria vesca L)extractsare thought to have hepatoprotective activities regarding the high activity of antioxidants contained.Method: Aspartate Transaminase (AST) activity was used as a marker of hepatotoxicity. In the 10 days trial, randomized samples of 24 male Wistar rats (Rattus Norvegicus) were used and divided into three groups: 1 group without treatment, 1 group receiving oral paracetamol 1750 mg/kg in CMC-Na suspension, and 1 group receiving oral paracetamol 1750 mg/kg following administration of strawberry extract 400 mg/kg. The strawberry extract was administered from day 1 to 10, while high-dose paracetamol was administered on day 9. AST activity analysis was done on day 10 of the trial. Significant results were found showing an increased AST activity in the paracetamol-only group (p=0.001) and a decreased AST activity in the group receiving strawberry extract (p=0.001). Conclusion: Fragaria vesca L extracts were proven in vivo to have hepatoprotective activities against paracetamol-induced hepatotoxicity
The Antioxidant Effect of Noni Fruits Extract on HDL and LDL Level of Wistar Rat Induced by High Fat Diet Diah Purwaningsari; Sihning EJ Tehupuring; Nita Pranitasari; Suhailah Hayaza; Lestari Dewi; Dian Ardiana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14704

Abstract

Dyslipidemia is an important risk factor for myocardial infarction, cardiovascular diseases, and Nonalcoholic Fatty Liver (NAFLD) disorders. Inflammatory conditions, oxidative stress, and insulin resistance,as well as several risk factors for cardiovascular disease, are also risk factors for this disease. This study aimsto determine the effect of noni (Morinda citrifolia) extract on the improvement of dyslipidemia condition,based on the Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) level. This research is alaboratory experimental study with a post-test only control group design. Male Wistar rat (Rattus norvegicus)were divided into four groups: negative control group with no induction and treatment (K-), positive controlgroup given high-fat diet induction for 14 days (K+), noni extract treatment group given a high-fat diet anda noni extract at a dose of 100 mg/kg BB per day for 7 days (P1), and noni extract at a dose of 200 mg/kgBB per day for seven days (P2). Low Density Lipoprotein and High Density Lipoprotein serum levels weremeasured using the ELISA method. The results showed that there was a significant increase in LDL and adecrease in HDL in both treatment groups (P1 and P2) compared with K(+) group. Therefore, we concludethat noni extract (Morinda citrifolia) played a role as an antioxidant which can increase LDL and decreaseHDL serum levels in rats induced by a high fat diet.
The Effect of Golden Sea Cucumber (StichopusHermanii) Extract on the Healing Process of the White Rat (Rattus Norvegicus) Indicated by Oral Ulcer– A Literature Review Dio Rafid Prakoso; Diah Purwaningsari; Sihning E.J.Tehupuring; Wachjudi Kurnia
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15725

Abstract

Background Indonesia is a maritime country that is rich in marine resources. There are many marine resources that can be used as herbal medicine. One of them is the golden sea cucumber which is thought to be used as an alternative medicine to speed up the healing process of oral ulcers. The purpose of this study was to determine the effect of golden sea cucumber extract (Stichopushermanii) on the wound healing process in rats with oral ulcers.Method This research is a descriptive study with a literature review design. The articles used are articles published in international and national journals in the 2015-2020 period and are indexed by Scopus, Thomson Reuters, Web Science, Scimago and Sinta.Result The results of the scoping article show that there are active compounds in golden sea cucumbers, namely glycosaminoglycans that consist of hyaluronic acid, heparin / heparan sulfate (HP / HS), chondroitin sulfate / dermatan sulfate (CS / DS) and keratin sulfate (KS) which can form proinflammatory cytokines to trigger the emergence of immune defense cells and can bind to growth factors such as FGF2, VEGF, TGF-b, which will provide stimulation to accelerate the angiogenesis process, fibroblast ploriferation, endothelial differentiation, epithelial differentiation so as to accelerate the wound healing process.ConclutionThe conclusion of this study is the golden sea cucumber has the potency to accelerate the wound healing process by increasing fibroblast formation, collagen synthesis, endothelial differentiation and epithelial differentiation.
The Effect of Brown Seaweed (Sargassum sp.) Extract on Apoptosis Process in Breast Cancer – A Literature Review Ismylatifa Devi; Diah Purwaningsari; Nita Pranitasari; HerinSetianingsih
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15803

Abstract

Breast cancer was one of the most common types of cancer in women and the major cause of death. Chemotherapy in breast cancer caused toxicity to the normal cells, resistance to the drugs, and several other side effects. Seaweed had many functional compounds that could be used as adjuvant therapy in breast cancer because of its anti-cancer properties called the proapoptotic agent. These compounds were fucoidan, phloroglucinol, and fucoxanthin. Their proapoptotic mechanisms shown by the journal were through increasing proapoptotic protein expression, decreasing antiapoptotic protein expression, inducing oxidative stress production on the cancer cell, and inhibiting the PI3K pathway. This review concludes that the brown seaweed (Sargassum sp.), which contains fucoidan, phloroglucinol, and fucoxanthin, could increase breast cancer cells’ apoptotic process.
Co-Authors Albertus Magnus Arya Abisatya Dian Ardiana Dio Rafid Prakoso HerinSetianingsih Ismylatifa Devi Lestari Dewi Liliawanti Nita Pranitasari Redemptus Yudadi Sihning E. J. T Sihning E.J.Tehupuring Sihning EJ Tehupuring Suhailah Hayaza Wachjudi Kurnia Wahyu Prasasti Mutiadesi