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All Journal Indonesian Journal of Pharmaceutical Science and Technology FITOFARMAKA: Jurnal Ilmiah Farmasi JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Kesehatan Madani Medika Jurnal Insan Farmasi Indonesia Parapemikir Jurnal Ilmiah Farmasi
Aji Najihudin
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics

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Journal : Jurnal Insan Farmasi Indonesia

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REVIEW ARTIKEL: SOLID LIPID NANOPARTICLES (SLN) METODE DAN KARAKTERISTIK Ilhanni Khoerunisa; Aji Najihudin; Siti Hindun
Jurnal Insan Farmasi Indonesia Vol 3 No 2 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i2.548

Abstract

Solid Lipid Nanoparticles are composed of active substances, solid fats, water and surfactants. SLN has advantages by having a small particle size of 50-1000 nm and a large absorption efficiency value of 40-100%. SLN has a homogeneous particle size with a IP value that is closed to zero. One of the methods used to produce SLN is HSH/ High pressure homogeneity where the process uses pressure to produce small particle size. The HSH/ High-speed homogeneity method uses stirring speed as a parameter in the manufacture of nanoparticles. Solvent emulsification method does not use high temperatures in the homogeneity process. The most important SLN characteristics are particle size and entrapment efficiency values. These characteristics are strongly influenced by large concentration of solid fat and surfactants. The greater amount of the surfactant used, the smaller the particle size and the increasing value of the trap efficiency. If the solid fat concentration used is greater, the particle size will be as larger, but the absorption efficiency value will be greater because the fat will provide more space for the active substance to be entrapped.
Co-Authors Ajeng Siti Fauziyah Anas Subarnas Anis Chaerunisaa Fajar Fauzi Abdullah Framesti Frisma Sriarumtias Hindun, Siti Ilhanni Khoerunisa Nazmi Syaqib Nopi Rantika Retty Handayani Retty Handayani Siti Hindun Siva Hamdani Syiami, Deska