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All Journal Indonesia Medicus Veterinus Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Universa Medicina Indonesian Journal of Rheumatology
Nur Atik
Departemen Biologi Sel
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Effect of Guava Extract Administration on Megakaryocytes Amount in Mice Femur Atik, Nur; Munawir, Maqrizi D. S.; Tarawifa, Susan; Darmadji, Hartati P.
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1010.183 KB) | DOI: 10.15416/ijcp.2017.6.2.116

Abstract

Dengue fever is a disease spread by mosquito’s bite. Dengue fever is marked by the presence of thrombocytopenia. Traditional crops such as guava are commonly used to treat dengue fever. This research aims to know the effect of guava extract administration towards megakaryocytes amount in mice femur. The study was conducted at the Laboratory of Pharmacology and Therapy, Histology Laboratory of Faculty of Medicine at Universitas Padjadjaran, Eijkman, Bandung from September until November 2016 using laboratory experimental study design. 20 Swiss webster mice strains were divided randomly into 4 groups. Group I and II were administered quinine 2.8 mg/20 grBW/day for 14 days to decrease amount of trombocytes. Group II and III were administered guava extract 0.785 mg/20 grBW/day for 5 days. Group IV was administered aquadest for 19 days. In the 27th day, the mice left femurs were collected and made into paraffin section preparations with hematoxylin-eosin staining and then observed under microscope. Group IV had the most megakaryocytes followed by Group II, III, and I. Based on Kruskal-Wallis test, a significant difference was shown (p<0.05). Mann- Whitney test showed that there were significant differences between Group I and Group II, III, and IV. Meanwhile there was no significant difference between normal mice and extract-given mice. Guava extract is proven statistically significant to increase the megakaryocytes amount in thrombocytopenic mice without increasing number of megakaryocytes in normal mice.
Memory Performance in Patient with Systemic Lupus Erythematosus Using MoCA-Ina in Hasan Sadikin Genneral Hospital Bandung Anjalia, Safira; Ong, Paulus Anam; Atik, Nur; Hamijoyo, Laniyati
Indonesian Journal of Rheumatology Vol 9, No 1 (2017)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: The involvement of neuropsychiatry is reported in 6% to 91% of Systemic Lupus Erythematosus (SLE) patients. It can cause fatal morbidity and mortality. Memory impairment is one of the most common symptoms of neuropsychiatry involvement. This study aims to find out the performance of memory test in SLE patients using Indonesian version of Montreal Cognitive Assessment (MoCA-Ina).Method: This cross sectional study recruited 30 SLE patients. Cognitive abilities and patient’s memory were examined using Indonesian version of Montreal Cognitive Assessment (MoCA-Ina). Cognitive impairment was determined when total MoCA-Ina score was below 26. For memory evaluation, immediate recall or delayed recall impairment was determined when the patient failed in each memory subtests.Results: The mean of total MoCA-Ina score was 24.97 (SD±3.14). Fifty percent of the SLE patients had cognitive impairment, with the domain involved being delayed recall (86.67%), attention (60%), language (56.67%), abstraction (53.33%), and visuo-spatial/ executive function (36.67%). Most patients (86.67%) could completely repeat immediate recall. Whileonly 4 (13.33%) subjects could repeat delayed recall completely without any clue. Of the 26 SLE patients who failed to recall completely, 24 (92.3%) of them succeeded to recall completely after getting clue(s).Conclusion: Memory impairment is the most frequent cognitive impairment in SLE patients, especially in delayed recall. By using the memory subtests of MoCAIna, more than four fifth of patients with SLE was detected having delayed recall memory impairment and almost all of them could recalled completely after getting clue(s). This findings indicated that the finalstep of memory process retrieval in SLE was interrupted while being encoded, but retention pathway were stillintact.Keywords: Systemic Lupus Erythematous, Memory, MoCA-Ina
The Pattern of Joints Involvement in Patients with Rheumatoid Arthritis in Rheumatology Clinic Dr. Hasan Sadikin General Hospital Bandung Pratama, Muhammad Kevin; Atik, Nur; Hamijoyo, Laniyati
Indonesian Journal of Rheumatology Vol 9, No 2 (2017)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with primary manifestation in the joints. Early management of RA will prevent further joint damage. The joint damages, result of uncontrolled disease activity, will decrease patient’s quality of life.RA should be diagnosed earlier and followed by early treatment initiation, in order to prevent further damages. This study aimed to determine the pattern of joint involvement in RA in order to made earlier diagnosis and treatment initiation.Method: This research was conducted using descriptive study design. Data were obtained using interview of RA patients who coming to Rheumatology Clinic of Dr. Hasan Sadikin General Hospital from August 2016 to October 2016. Collected data included number of joints involvement, duration of therapy, and duration of illness after diagnosed according to the criteria of ACR / EULAR 2010.Result: Ninety-seven RA patients were involved in this study. Subjects were dominantly women (87%), the highest age group was 45-49 years old (17.53%), duration of the disease <5 years (90.72%), and duration of therapy > 3 months (86%). Joint that frequently involved at the time when the diagnosis made was first proximal interphalangeal (49.50%), overall findings during the course of RA was the wrist joint (90.72%).There were different tendency of joint involvement between the gender, knee joints occured in 53,84% male subjects, while PIP joints were accounted for 52,38% infemale subjects.Conclusion: The first PIP was the most common joint involved in RA patients when the diagnosis made. The wrist joint involvement was dominantly found in overall course of RA. Knee joint involvement was majorly found in male RA patients, whereas female RA patients would suffer mostly from PIP joint involvement.Keywords: involvement pattern, joints, rheumatoid arthritis
Guava leaf juice effect towards number of megakaryocytes in bone marrow of thrombocytopenic mice Atik, Nur; Amrullah, Al Hadi; Rahmadi, Andri Reza
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.19-24

Abstract

BackgroundDengue virus infection that most frequently occur in tropical and subtropical regions can cause many symptoms, one of which is a decrease in thrombocyte count. Recent studies showed that guava leaf extract can increase the thrombocyte count in rats. The present study aimed to determine the effect of guava leaf juice in increasing the number of megakaryocytes in the bone marrow of thrombocytopenic mice.MethodsThis study was of experimental design. The study subjects were 24 mice (Mus musculus). The mice were randomly divided into four groups that were subjected to intervention for 14 days. Group 1 was given guava leaf juice (56 mg/kg) and quinine (14 mg/kg), group 2 guava leaf juice (56 mg/kg) only, group 3 was given quinine (14 mg/kg) and group 4 distilled water. After 14 days, from the bone marrow of the femoral bones of each of the mice, hematoxylin eosin stained histologic preparations were made. Anova test was used to analyze the data.ResultsThe mean megakaryocyte count per field of view in group 1 (2.83), group 2 (3.30), group 3 (2.24) and group 4 (2.93). Anova test results for all groups showed significant differences between groups (p&lt;0.05). The mean megakaryocyte count was increased in group 1 compared to group 3, but the difference was statistically not significant (p=0.206).Conclusion Guava leaf juice can increase the megakaryocyte count in the bone marrow of thrombocytopenic mice. This suggests a potential role of guava leaf juice in improving the platelet count in thrombocytopenic disorders.
Demographic and Risk Factors of Intracerebral Hemorrhage Stroke Patients in Dr. Hasan Sadikin General Hospital Bandung in 2007–2016 Lofissa, Sabrina Putri; Ong, Paulus Anam; Atik, Nur
Althea Medical Journal Vol 5, No 1 (2018)
Publisher : Althea Medical Journal

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Abstract

Background: Intracerebral hemorrhage stroke is a type of stroke which is considered to have a higher mortality risk than ischemic stroke. Preventive programs are needed to minimize stroke cases by reducing the risk factors. This study aimed to identify the demographic and risk factors of intracerebral hemorrhage stroke patients in Dr. Hasan Sadikin General Hospital Bandung in 2007–2016. Methods: This was a descriptive cross sectional study. Data were obtained from Dr. Hasan Sadikin General Hospital medical resume January 2007- December 2016 by total sampling.  Subjects of this study were intracerebral hemorrhage stroke patients hospitalized in Dr. Hasan Sadikin General Hospital. The period of study was from August 2016 until May 2017. Variables included in this study were gender, occupation, education level, age; risk factors such as hypertension, dyslipidemia, diabetes mellitus, hyperuricemia, and kidney disease. The collected data were presented in percentage.Results: The highest demographic prevalence in 10 years was in female, non-occupational person, elementary school graduate, and frequently found in the 50-59 age group. The highest risk factor was hypertension, but it slightly decreased from 78.8% in 2007-2008 to 55.3% in 2015-2016, followed by dyslipidemia, diabetes mellitus, hyperuricemia which increased in 2007-2008 and 2015-2016. (Dyslipidemia: from 8.1% to 23.8%; Hyperuricemia: from 2.5% to11.2%; Diabetes Mellitus: from 6.6% to 8.9%).Conclusions: The demographic of intracerebral hemorrhage stroke shows a high prevalence found in females, older age, non-occupational persons, and elementary school graduates. Among the risk factors, hypertension is most likely to happen in ten years. 
PERBEDAAN EFEK PEMBERIAN TOPIKAL GEL LIDAH BUAYA (ALOE VERA L.) DENGAN SOLUSIO POVIDONE IODINE TERHADAP PENYEMBUHAN LUKA SAYAT PADA KULIT MENCIT (MUS MUSCULUS) Atik, Nur; Iwan A. Rahman, Januarsih
Majalah Kedokteran Bandung Vol 41, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Penyembuhan luka yang normal merupakan suatu proses kompleks dan dinamis. Proses penyembuhan dapat dibantu baik dengan pengobatan secara kimiawi maupun alami. Pengobatan kimiawi biasanya menggunakan povidone iodine sedangkan salah satu cara alami dengan pemberian topikal gel lidah buaya (Aloe vera L.) yang diduga dapat mempercepat proses penyembuhan luka. Tujuan penelitian ini untuk mengetahui perbedaan penyembuhan luka sayat yang diberikan topikal gel lidah buaya dengan povidone iodine pada kulit mencit. Penelitian ini menggunakan 18 mencit (Mus musculus) yang terbagi dalam 3 kelompok, yaitu kelompok luka sayat (kontrol), kelompok luka sayat ? lidah buaya, dan kelompok luka sayat povidone iodine. Setiap kelompok dibuat full-thickness skin wound di punggung mencit. Luka pada grup kontrol tidak diberikan perlakuan, sementara gel lidah buaya diberikan secara topikal sebanyak 2 kali/hari pada grup kedua, dan solusio povidone iodine diberikan sebanyak 2 kali/hari pada grup ketiga. Pada hari kelima semua mencit dikorbankan untuk dievaluasi perubahan histologik dan ekspresi vascular endothelial growth factor A (VEGF-A). Data diperoleh melalui pengamatan mikroskopik terhadap jaringan kulit yang terluka, dengan parameter tebal epitel, jumlah rata-rata sel fibroblas, pembuluh darah dan ekspresi VEGF A, kemudian dianalisis statistik menggunakan independent samples T test, Analisis of variant (ANOVA) dan Chi square. Dari hasil penelitian didapatkan tebal epitel, jumlah rata-rata fibroblas, pembuluh darah, dan ekspresi VEGF A pada kelompok luka sayat -lidah buaya lebih tebal dan lebih banyak jika dibandingkan dengan kelompok povidone iodine. Melalui uji statistik dapat diketahui adanya perbedaan yang bermakna (p < 0,05) tebal epitel, jumlah rata-rata sel fibroblas; pembuluh darah dan ekspresi VEGF A pada kedua kelompok dengan taraf kepercayaan 95%. Hal ini menandakan bahwa pemberian topikal gel lidah buaya pada luka sayat kulit mencit sebanyak dua kali sehari lebih baik daripada pemberian solusio povidone iodine dilihat dari parameter tebal epitel, jumlah rata-rata fibroblas, pembuluh darah, dan ekspresi VEGF A.Kata kunci: Lidah buaya (Aloe vera L.), solusio povidone iodine, penyembuhan luka sayat, pemberian topikalTHE DIFFERENCES BETWEEN TOPICAL APLICATION OF THE ALOE VERA GEL WITH THE POVIDONE IODINE SOLUTIO FOR SKIN WOUND HEALING IN MICE (Mus Musculus)Normal wound healing is a complex and dynamic process. Wound healing process can accelerate, with chemical treatment or natural. The chemical treatment often used in healing process is povidone iodine. For natural treatment, topical application of Aloe vera gel may accelerate the full-thickness wound healing process. The purpose of this research was to evaluate the differences between topical application of povidone iodine and Aloe vera gel for skin wound healing in mice. This study used 18 mice that were divided into three groups. First group was the wounded (control) group, the second group was wounded ? Aloe vera group, the third group was wounded - povidone iodine group. Full-thickness skin wound were created on the dorsal area of mice in each group. The control group were not given anything, while the second group were given Aloe vera gel twice a day, and the third group were given povidone iodine solution twice a day. At the fifth day, all mice were sacrificed for histologic evaluation and VEGF A expression. Data was obtained by microscopic observation of the wounded skin, based on quantitative parameter: epithelial thickness, total fibroblast, total blood vessels, and VEGF A expression. Then the data was statistically analyzed by using independent samples T test, ANOVA, and Chi square. The result demonstrated that the sum of epithelial thickness, fibroblast, blood vessels, and VEGF A expression in the Aloe vera group is higher than in povidone iodine group.  Statistic evaluation showed that there were significant differences between the two groups (p < 0.05), with 95% confidence interval. Based on this result, it can be concluded that the topical administration of Aloe vera gel twice a day is better than povidone iodine with parameter epithelial thickness, total fibroblass, total blood vessels and VEGF A expression.Key words: Aloe vera, povidone iodine solution, lacerating wound healing, topical application DOI: http://dx.doi.org/10.15395/mkb.v41n2.188
Perbandingan Pemberian Topikal Aqueous Leaf Extract of Carica Papaya (ALEC) dan Madu Khaula Terhadap Percepatan Penyembuhan Luka Sayat pada Kulit Mencit (Mus musculus) Iwan, Januarsih; Atik, Nur
Majalah Kedokteran Bandung Vol 42, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Madu dan pepaya telah lama dipercaya oleh masyarakat kita memiliki efek penyembuhan luka. Penelitian ini bertujuan untuk membandingkan percepatan penyembuhan luka sayat yang diberikan Aqueous Leaf Extract of Carica Papaya (ALEC) dengan madu Khaula. Penelitian dilakukan pada periode November 2006-April 2007 di Laboratorium Bagian Histologi, Fakultas Kedokteran Universitas Padjadjaran, Bandung. Subjek penelitian eksperimental ini berupa mencit jantan galur ddy dibagi dalam 3 kelompok (setiap kelompok terdiri dari 9 mencit), kelompok gel solcoseryl sebagai kontrol standar, ALEC 10% dalam vaselin dan madu 1,0 g sebagai kelompok perlakuan. Mencit dibuat luka sayat pada daerah punggung kemudian diberikan pengobatan topikal sesuai dengan kelompoknya. Untuk melihat perubahan histologi kulit mencit dikorbankan pada hari ke-4, ke-7, dan ke-10 setelah perlukaan. Data berupa gambaran histologi kulit berdasarkan regenerasi epidermis, ketebalan granulasi jaringan dan angiogenesis, kemudian dianalisis menggunakan uji parametric independent T-test dengan nilai p< 0,05. Hasil penelitian ini menunjukkan perbedaan bermakna antara kelompok kontrol dan ALEC 10% dalam vaselin melalui tiga parameter di atas. Perbandingan antara kelompok kontrol dan madu Khaula menunjukkan perbedaan hanya pada regenerasi epidermis dan angiogenesis. Penggunaan ALEC 10% dalam vaselin dan penggunaan madu Khaula pada luka menunjukkan perbedaan bermakna pada regenerasi epidermis (rata-rata 2,19 (0,81) untuk ALEC 10% dan 2,67 (0,67) untuk kelompok madu, nilai p < 0,001) dan ketebalan jaringan granulasi (rata-rata 2,99 (0,94) untuk ALEC 10% dan 3,23 (0,99) untuk kelompok madu, nilai p 0,038). Hasil ini menunjukkan adanya perbedaan antara ALEC dan madu Khaula dalam percepatan penyembuhan luka, khususnya percepatan regenerasi epidermis dan granulasi jaringan. The Comparation Between Topical Aplication of the Aqueous Leaf Extract of Carica Papaya (ALEC) & Khaula Honey in Accelerating Skin Wound Healing in MiceTopical application of papaya and honey has been hypothesized to accelerate skin wound healing. The purpose of this research was to evaluate the differences between topical application of the ALEC and Khaula Honey in accelerating skin wound healing in mice. The experiment took place in Histology Laboratory, School of Medicine, Padjadjaran University, Bandung, November 2006-April 2007.The prospective experimental method was held in 10 days. Subjects were male ddy mice divided into 3 groups (each consisted of 9 mices), which were control group solcoseryl jelly, 10% ALEC in vaseline and 1.0 g Khaula honey treated group. The comparisons in accelerating skin wound healing were investigated by using full thickness skin wound model produced on the back of the mice. Solcoseryl jelly was applied topically to wound of group 1, group 2 and group 3 mice were treated topically with 10% ALEC in vaseline and Khaula honey, respectively. The mice were sacrificed on 4th, 7th, and 10th day of post wounding for evaluating the histological changes. Data was obtained by microscopically analysis of the skin based on the epidermal regeneration, granulation tissues thickness and angiogenesis and then analyzed by using parametric independent T-test. The level for statistical significant was set p < 0.05. The result of this experiment showed that there were significant difference between control group and ALEC10% in vaseline in three mentioned above. Comparison between control and Khaula honey showed differences only in epidermal regeneration and angiogenesis. Wound treated with ALEC 10% in vaseline and Khaula honey group showed significantly difference in epidermal regeneration (mean 2.19 (0.81) for ALEC 10% and 2.67 (0.67) for honey group, p value < 0.001) and granulation tissues thickness (mean 2.99 (0.94) for ALEC 10% and 3.23 (0.99) for honey group, p value 0.038).These result documented the differences of ALEC and Khaula honey for the acceleration of wound healing process in full thickness skin wound especially in epidermal regeneration and granulation tissues thickness.DOI: http://dx.doi.org/10.15395/mkb.v42n2.13
Kajian Pustaka: Pemanfaatan Biji Kapulaga Jawa (Amomum compactum) Sebagai Antiinflamasi dan Antibiotic Growth Promoter Alternatif untuk Ternak Praditha, Arvia Nisrina; Hartady, Tyagita; Atik, Nur
Indonesia Medicus Veterinus Vol 9 (6) 2020
Publisher : Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/imv.2020.9.6.959

Abstract

Antibiotic growth promoter (AGP) telah digunakan pada hewan produksi untuk meningkatkan pertumbuhan dan efisiensi konversi pakan. Namun, beberapa penelitian menunjukkan bahwa aktivitas utama beberapa AGP dapat disebabkan oleh efek antiinflamasinya yang menyebabkan penurunan katabolisme otot dan pencegahan anoreksia. Hal tersebut membuat energi banyak disimpan untuk perkembangan otot dan pertumbuhan. Meskipun penggunaan AGP telah menjadi praktik umum pada hewan produksi, penggunaannya yang ekstensif telah berkontribusi pada munculnya resistensi antimikrob patogen zoonosis. Salah satu strategi yang menjanjikan adalah dengan mencari alternatif AGP yaitu dengan penggunaan obat herbal sebagai terapi integratif, komplementer dan preventif. Kapulaga jawa (Amomum compactum) banyak dimanfaatkan secara tradisional pada bidang medis dan telah diteliti mengenai efek antiinflamasi, efek protektif pada saluran cerna, serta pada peningkatan daya cerna pakan pada fermentasi rumen. Metodologi yang digunakan dalam penelitian ini yaitu dengan penelusuran literatur melalui pencarian data pada basis data Pubmed, Science Direct, maupun Google Scholar untuk penelitian ini yang dipublikasikan dalam kurun waktu 10 tahun terakhir. Hasil studi literatur ini membahas peran antiinflamasi dari A. compactum yang dapat dimanfaatkan sebagai alternatif penggunaan AGP. Hal ini berkaitan dengan penurunan energi katabolik pada respons fase akut yang menyebabkan energi lebih banyak disimpan untuk tujuan perkembangan otot dan pertumbuhan. Pemahaman lebih jauh mengenai mekanisme A. compactum sebagai alternatif AGP tentunya sangat diperlukan sehingga akan dapat dihasilkan produk alternatif AGP yang efektif tanpa mendorong resistensi antimikrob.
Co-Authors Amrullah, Al Hadi Andri Reza Rahmadi, Andri Reza Anjalia, Safira Darmadji, Hartati P. Iwan A. Rahman, Januarsih Januarsih Iwan Laniyati Hamijoyo, Laniyati Lofissa, Sabrina Putri Munawir, Maqrizi D. S. Ong, Paulus Anam Ong, Paulus Anam Praditha, Arvia Nisrina Pratama, Muhammad Kevin Tarawifa, Susan Tyagita Hartady