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All Journal Medical Journal of Indonesia The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Penyakit Dalam Indonesia

Diana Aulia

Faculty of Medicine, University of Indonesia/ Cipto Mangunkusumo National Hospital, Jakarta

Author-ID : 236796

Agriculture, Biological Sciences & Forestry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 4 Documents Claim Missing Document

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Articles

Correlation between urinary albumin to creatinine ratio and systemic glycocalyx degradation in pediatric sepsis Saragih, Rina A.C.; Pudjiadi, Antonius H.; Tambunan, Taralan; Satari, Hindra I.; Aulia, Diana; Bardosono, Saptawati; Munasir, Zakiudin; Lubis, Munar
Medical Journal of Indonesia Vol 27, No 3 (2018): September
Publisher : Faculty of Medicine Universitas Indonesia

Background: Increased capillary permeability in sepsis is associated with several complications and worse outcomes. Glycocalyx degradation, marked by increased serum syndecan-1 levels, alters vascular permeability, which can manifest as albuminuria in the glomerulus. Therefore, elevated urinary albumin to creatinine ratio (ACR) potentially provides an index of systemic glycocalyx degradation. The aim of this study was to analyze the correlation between urinary ACR and serum syndecan-1 levels.Methods: A longitudinal prospective study with repeated cross-sectional design was conducted on children with sepsis in pediatric intensive care unit, we evaluated serum syndecan-1 levels and urinary ACR on days 1, 2, 3, and 7. A descriptive study on healthy children was also conducted to determine the reference value of syndecan-1 in children.Results: 49 subjects with sepsis were recruited. Based on the data of the healthy children group (n=30), syndecan-1 level of >90th percentile (41.42 ng/mL) was defined as systemic glycocalyx degradation. The correlation coefficients (r) between urinary ACR and syndecan-1 levels were 0.32 (p<0.001) from all examination days (162 specimens), 0.298 (p=0.038) on day 1, and 0.469 (p=0.002) on day 3. The area under the curve of urinary ACR and systemic glycocalyx degradation was 65.7% (95% CI 54.5%–77%; p=0.012). Urinary ACR ≥157.5 mg/g was determined as the cut-off point for glycocalyx degradation, with a sensitivity of 77.4% and a specificity of 48%.Conclusion: Urinary ACR showed a weak correlation with systemic glycocalyx degradation, indicating that the pathophysiology of elevated urinary ACR in sepsis is not merely related to glycocalyx degradation.

Antibiotic Associated Diarrhea in Hospitalized Adult Patients Simadibrata, Marcellus; Chen, Lie Khie; Aulia, Diana; Timan, Ina Sutanto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 1 (2018): VOLUME 19, NUMBER 1, April 2018
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Background: Antibiotic associated diarrhea (AAD) occurs from the first initiation until 2 months of the end of antibiotic treatment. The aims of this study were to know the incidence of AAD, Clostridium difficile infection and other gastrointestinal symptoms in hospitalized adult patients.Method: The study is a cross sectional study. We studied the antibiotic associated diarrhea (AAD), Clostridium difficile infection and other gastrointestinal symptoms in patients who were admited in Cipto Mangunkusumo Hospital. Inclusion were male or female, age 18-75 years old, Patients started receiving antibiotics maximal 2 x 24 hours prior to hospitalization, gave written informed consent.Results: The incidence of AAD was 11.5%. The incidence of Clostridium difficile infection was 15.4%. The Upper gastrointestinal symptom was present on 20 (38.5%) patients. Lower abdominal symptom was present on 10 (19.2%) patients.Conclusion: The Incidence of AAD and Clostridium difficile infection were 11.5% and 15.4% respectively. The clinical manifestations of AAD were diarrhea, other upper and lower abdominal symptoms.

Gambaran Laboratorium pada Sindroma Nefrotik Tjiptaningrum, Agustyas; Aulia, Diana
Jurnal Kedokteran Universitas Lampung Vol 3, No 2 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i2.2500

Seorang anak perempuan usia 13 tahun, datang ke IGD RSUPN Cipto Mangunkusumo dengan keluhan bengkak seluruh badan.. Tiga bulan sebelum masuk RS, terdapat bercak merah di dahi, pinggang, perut, dan kaki, bercak terasa gatal, berobat ke puskesmas diberi obat oles. Setelah dioleskan obat bercak merah bertambah merah sehingga obat dihentikan. Dua bulan sebelum masuk RS, wajah, kaki, dan tangan bengkak, BAK banyak, tidak nyeri, warna urin kadang bening kadang seperti air cucian daging, volume urin banyak, tidak ada demam, riwayat batuk pilek dan sakit tenggorokan disangkal. Pasien berobat ke puskesmas Cibinong dan mendapat obat tablet warna hijau dan amoksisilin. Setelah minum obat ada perbaikan.Dua hari sebelum masuk RS, wajah pasien bengkak, kaki dan tangan juga bengkak. Keluhan disertai mual dan muntah. Riwayat alergi anak maupun keluarga semua disangkal.Pada pemeriksaan fisik tampak sakit sedang, hipertensi dengan tekanan darah 160/100 mmHg, konjungtiva palpebrae anemis, edema pada palpebra superior, wajah, dan kedua ekstremitas, serta asites. Hasil pemeriksaan laboratorium didapatkan proteinuria(+3), leukosituria, hematuria, uremia, peningkatan kreatinin, hipoalbuminemia, hiperkolesterolemia, anemia, leukositosis, dan trombositosis. Berdasarkan data diatas, pasien didiagnosis sebagai sindroma nefrotik dengan diagnosis banding nefritis akut. Untuk pemeriksaan lanjutan disarankan pemeriksaan protein total, protein kuantitatif urin, anti streptolisin O, anti nuclear antibody (ANA), anti dsDNA, C3 dan C4.Kata kunci: edema, hipertensi, kreatinin, proteinuria, uremia, sindroma nefrotik

Update in Laboratory Diagnosis of Urinary Tract Infection Rinawati, Weny; Aulia, Diana
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Urinary tract infection (UTI) is an infection caused by the entry of pathogens into the urinary tract. Symptoms of a UTI are not always obvious, and some are asymptomatic or atypical. Urinary tract infections must be distinguished from other diseases that have a similar clinical appearance. Many UTIs resolve spontaneously, but often cause significant morbidity and mortality. With the unpredictable nature of the disease, laboratory tests are required for accurate diagnosis and identification of the cause of infection. Thus, it is necessary to understand the interpretation and limitations of urinalysis and urine culture results. To assist in the diagnosis of urinary tract infections, flowcytometry is currently being developed. With the ability to detect bacteria, this tool can be used for UTI screening in the pre-analytic phase of urine culture

Co-Authors Agustyas Tjiptaningrum Antonius H. Pudjiadi, Antonius H. Hindra I. Satari, Hindra I. Lie Khie Chen Marcellus Simadibrata Munar Lubis, Munar Rina A.C. Saragih, Rina A.C. Saptawati Bardosono Taralan Tambunan Timan, Ina Sutanto Weny Rinawati Zakiudin Munasir

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