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All Journal Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Journal of Issues in Midwifery Jurnal Indonesia Sosial Sains Journal Research of Social Science, Economics, and Management
Fatmawati Fatmawati
Brawijaya University, Malang
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Indonesia Sosial Sains

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The Effect of High Dosage of Iron Supplementation (Fe) Against Histopathology of Gastric Mucosa in Pregnant Strain Wistar White Rats (Rattus norvegicus) Fatmawati Fatmawati; Dyah Aulia Perwitasari
Jurnal Indonesia Sosial Sains Vol. 4 No. 04 (2023): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v4i04.804

Abstract

Pregnant women are encouraged to consume iron tablets during their pregnancy or at least 90 tablets during pregnancy. Side effects of iron tablets include nausea, vomiting, diarrhea, constipation. If the tablets is consumed in excess it will cause toxicity because excess iron will cause oxidative stress which can affect the state of the stomach. Purpose: to determine the effect of high-dose iron (Fe) supplementation on the histopathology of gastric mucosa in pregnant strain Wistar white rats (Rattus norvegicus). This study used 24 pregnant rats divided into 4 groups, that is, negative controls; treatment 1 with a dose of 0.54 mg; treatment 2 with a dose of 1.08 mg; and treatment 3 with a dose of 2.16 mg. Iron (Fe) supplementation was started from the 1st day of pregnancy until the 18th day, then on the 19th day the rats were dissected and the gastric organ was taken as a preparation with Hematoxylin Eosin (HE) staining and then observed with a light microscope. This study showed the histopathological results of gastric mucosa damaged in the treatment group which was assessed using the Barthel Manja score. The One Way ANOVA test results showed a significant difference from gastric mucosa (p = 0.000) in the control and treatment groups of this study. High doses of iron (Fe) supplementation affect the histopathology of gastric mucosa.
Co-Authors Berliana Maduratna Irawati Diadjeng Setya Wardani Dyah Aulia Perwitasari Hafidza Auliya Lilik Indahwati Meiliana Eka Savitri Mergy Gayatri Mita Herlina Sari Mustika Dewi Nabila Sinta Devi Triyana Sinta Dewi