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All Journal HAYATI Journal of Biosciences Bioma CERATA Jurnal Ilmu Farmasi CERATA
RINI PUSPITANINGRUM
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Immunology & microbiology Medicine & Pharmacology

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Mutation of mtDNA ND1 Gene in 20 Type 2 Diabetes Mellitus Patients of Gorontalonese and Javanese Ethnicity AMIEN RAMADHAN ISHAK; RINI PUSPITANINGRUM; RISMA DWI UTARI; MELLA FERANIA; CHRIS ADHIYANTO; TAKENORI NITTA; AB SUSANTO; HATTORI YUKIO; YASUHIRO YAMASHIRO
HAYATI Journal of Biosciences Vol. 21 No. 4 (2014): December 2014
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1244.737 KB) | DOI: 10.4308/hjb.21.4.159

Abstract

Mitochondrial gene mutation plays a role in the development of type two diabetes mellitus (T2DM). A point mutation in the mitochondrial gene Nicotinamide adenine dinucleotide dehydrogenase 1 (mtDNA ND1) gene mainly reported as the most common mutation related to T2DM. However, several studies have identified another SNP (single-nucleotide polymorphisms) in the RNA region of mtDNA from patients from specific ethnic populations in Indonesia. Building on those findings, this study aimed to use PCR and DNA sequencing technology to identify nucleotides in RNA and ND1 fragment from 20 Gorontalonese and 20 Javanese T2DM patients, that may trigger T2DM expression. The results showed successful amplification of RNA along 294 bp for all samples. From these samples, we found two types of point  mutation in Javanese patients in the G3316A and  T3200C points of the rRNA and ND1 gene. In samples taken from Gorontalonese patients, no mutation were found in the RNA or ND1 region. We conclude that T2DM was triggered differently in our two populations. While genetic mutation is implicated for the 20 Javanese patients, T2DM pathogenesis in the Gorontalonese patients must be traced to other genetic, environmental, or behavioral factors.
Pengaruh Paparan Hipoksia terhadap Aktivitas Antioksidan Katalase dan Kadar Malondialdehid (MDA) pada Jaringan Hati Tikus Rini Puspitaningrum; Amanda Putri Lestari; Tri Murtiati
Bioma Vol 10 No 2 (2014): Bioma
Publisher : Biologi UNJ Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.329 KB) | DOI: 10.21009/Bioma10(2).5

Abstract

Abstract content in the tissue. Hypoxia can make the formation of free radicals or reactive oxygen species (ROS) which reactive to cell membrane. Body will avoid free radicals by producing antioxidant, such as catalase enzyme. The reaction between ROS and cell membrane will form malondialdehyde (MDA). Liver is the main location of catalase. This research was aimed to know the influence of hypoxia exposure toward catalase antioxidant activity and MDA content in the rat liver tissue. This research used experiment method with fully randomized design. Based on one way Anova test (p≤0.01), it was shown that there had no average difference on catalase activity and MDA content toward length hypoxia exposure. The conclusion of this research was no influence of hypoxia exposure toward catalase activity and MDA content in rat liver tissue. Key words: catalase antioxidant activity, hypoxia, malondialdehyde (MDA) content,rat liver tissue
STUDI LITERATUR DAMPAK KORTIKOSTEROID PADA WANITA HAMIL DAN PERTUMBUHAN JANIN Reza Dino Mahardika; Feni Oetari; Rini Puspitaningrum
CERATA Jurnal Ilmu Farmasi Vol 13 No 1 (2022): Cerata Jurnal Ilmu Farmasi
Publisher : UNIVRSITAS MUHAMMADIYAH KLATEN

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Abstract

Kortikosteroid yang dibuat secara sintetis berperan penting dalam dunia medis. Kortikosteroid digunakan dalam pengobatan antiinflamasi, penyakit kulit dan autoimunitas. Penggunaan kortikosteroid pada penulisan ini dibatasi pada wanita hamil. Wanita hamil dan janin yang dikandung sangat rentan terhadap obat kortikosteroid. Efek kortikosteroid yang dapat meningkatkan tekanan darah beresiko menyebabkan preeklampsia pada wanita hamil. Selain itu kortikosteroid berpotensi mengganggu proses fisiologis plasenta. Meskipun demikian, obat kortikosteroid memiliki dampak positif terhadap wanita hamil, seperti meningkatkan pembentukan surfaktan dan perkembangan paru-paru pada janin.
STUDI LITERATUR DAMPAK KORTIKOSTEROID PADA WANITA HAMIL DAN PERTUMBUHAN JANIN Reza Dino Mahardika; Feni Oetari; Rini Puspitaningrum
CERATA Jurnal Ilmu Farmasi Vol 13 No 1 (2022): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v13i1.455

Abstract

Kortikosteroid yang dibuat secara sintetis berperan penting dalam dunia medis. Kortikosteroid digunakan dalam pengobatan antiinflamasi, penyakit kulit dan autoimunitas. Penggunaan kortikosteroid pada penulisan ini dibatasi pada wanita hamil. Wanita hamil dan janin yang dikandung sangat rentan terhadap obat kortikosteroid. Efek kortikosteroid yang dapat meningkatkan tekanan darah beresiko menyebabkan preeklampsia pada wanita hamil. Selain itu kortikosteroid berpotensi mengganggu proses fisiologis plasenta. Meskipun demikian, obat kortikosteroid memiliki dampak positif terhadap wanita hamil, seperti meningkatkan pembentukan surfaktan dan perkembangan paru-paru pada janin.
Co-Authors AB SUSANTO Amanda Putri Lestari AMIEN RAMADHAN ISHAK CHRIS ADHIYANTO Feni Oetari HATTORI YUKIO MELLA FERANIA Reza Dino Mahardika RISMA DWI UTARI TAKENORI NITTA Tri Murtiati YASUHIRO YAMASHIRO