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Mohd Azam Khan
Faculty of Veterinary Medicine, UMK City Campus, Pengkalan Chepa, Locked Bag 36, 16100 Kota Bharu, Kelantan
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences

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Micronuclei Formation and 8-Hydroxy-2-Deoxyguanosine Enzyme Detection in Ovarian Tissues After Radiofrequency Exposure at 1800 MHz in Adult Sprague–Dawley Rats Ali Saeed Hammoodi Alchalabi; Hasliza Rahim; Mohamed Fareq AbdulMalek; Erkihun Aklilu; Abd Rahman Aziz; Suzanna Harun Ronald; Mohd Azam Khan
HAYATI Journal of Biosciences Vol. 24 No. 2 (2017): April 2017
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2191.188 KB) | DOI: 10.4308/hjb.24.2.79

Abstract

Human fertility and its correlation to ovarian function and cytological changes are linked to ever-increasing use of mobile phones. Wireless communications have become a critical topic of concern because of an increasing number of studies in this field with controversial outcomes. The aim of this study was to assess the genotoxic effect of GSM frequency at 1800 MHz on ovarian function. Sixty female Sprague–Dawley rats were distributed over six groups (control group and the exposure groups with whole-body exposure for 2 h/day, 7 days/week for 15, 30 and 60 continuous days). The study investigated the oxidative stress, 8-hydroxy-2-deoxyguanosine enzyme, micronuclei formation and histopathological changes in ovarian tissue. The results showed an induced oxidative stress via an increase in lipid peroxidation and decreased antioxidant enzyme activity. There was also an elevation in the 8-hydroxy-2-deoxyguanosine enzyme and an increased rate of micronuclei formation in ovarian tissues of exposed animals with 60-day exposure compared with control animals. Cytological changes were recorded such as micronuclei formation, vacuolation, degeneration and impaired folliculogenesis. The study suggests that GSM frequency at 1800 MHz was negatively impacted on female reproductive performances mediated by oxidative stress induction and 8-hydroxy-2-deoxyguanosine formation leading to overall impaired ovarian function.
Co-Authors Abd Rahman Aziz Ali Saeed Hammoodi Alchalabi Erkihun Aklilu Hasliza Rahim Mohamed Fareq AbdulMalek Suzanna Harun Ronald