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All Journal HAYATI Journal of Biosciences Jurnal Teknik ITS Jurnal Sains dan Seni ITS IPTEK Journal of Proceedings Series IPTEK The Journal for Technology and Science The Journal of Pure and Applied Chemistry Research Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Chemistry Akta Kimia Indonesia NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN

Sri Fatmawati

Departemen Kimia, Institut Teknologi Sepuluh Nopember

Author-ID : 2420467

Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 19 Documents Claim Missing Document

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In vitro and In vivo Antiplasmodial of Stem Bark Extract of Garcinia husor Healthy Kainama; Sri Fatmawati; Mardi Santoso; Pieter Kakisina; Taslim Ersam
HAYATI Journal of Biosciences Vol. 26 No. 2 (2019): April 2019
Publisher : Bogor Agricultural University, Indonesia

Garcinia husor is one of the folk medicines in Maluku-Indonesia. This species has been used for the treatmet of Malaria disease. The phytochemical contents and antiplasmodial activity not reported yet. In this study we evaluated the quantitative phytochemicals, in vitro and in vivo antiplasmodial activity of stem bark ethyl acetate extract. In vitro assay was done using P. falciparum 3D7 strain sensitive of chloroquine. For in vivo analysis, four groups of M. musculus were infected by P. berghei and their parasitemia levels were for 7 days of treatment with ethyl acetate extract; hematological and biochemical parameter were analyzed at the end of experiment. The result showed ethyl acetate extract with the TPC (169.47 mg GAE/100 g ±0.61) and TPC (167.37 mg QE/100 g ±1.05) was active against P. falciparum 3D7 strain (IC50 value of 0.31±0.43 μg/ml). The animal treated with extract showed suppression of parasitemia to 87.57±1.41% compared with the P. berghei infected-mice (negative control), ED50 value of 22.30 mg/kg BW. The dose of extract in 200 mg/kg BW was reduce parasitemia of infected mice with P. berghei more potential. The ethyl acetate of the stem bark G. husor with has antiplasmodial properties and future investigation are necessary to elucidate its mechanism of action.

Phytochemical, Antibacterial, and Antioxidant Activities of Anthurium Hookerii leaves Extracts Atmira Sariwati; Inayah Fitri; Adi Setyo Purnomo; Sri Fatmawati
HAYATI Journal of Biosciences Vol. 26 No. 3 (2019): July 2019
Publisher : Bogor Agricultural University, Indonesia

Many plants of the family of Araceae possess significant benefit as medicinal plants. Anthurium hookerii is herbaceous genus of the family of Araceae. A. hookerii leaves were extracted with five dissimilarity solvents (methanolic, water, ethyl acetate, n-hexane, and dichloromethane). The extracts were evaluated for their phytochemical, total phenolic contents, and antibacterial potential. The presences of tannins and saponins were found in all crude extracts. The steroid was only found in dichloromethane extract, whereas flavonoid was obtained in methanol and water extracts. Besides; methanol, ethyl acetate, water, and n-hexane extracts showed triterpenoid contents. Alkaloid presences in ethyl acetate, methanolic, dichloromethane, and water extracts. The total phenol content was examined by Follin-Ciocalteu assay, which varied from 9.52-76.56 mg/g GAE. The highest total phenolic was found in methanol extract. Antioxidant activity was calculated based on diphenyl picryl hydrazyl radical scavenging ability that showed the scavenging activity with range 7.24-66.11%, which the methanoilic extract have the excellent antioxidant potential (IC50 232.90 µg/ml). Antibacterial activity of leaves extracts of A. hookerii was screened based on disc diffusion method. Water extract showed the wide spectrum antibacterial potential. Klebsiella sp., Bacillus subtilis, Pripioni agnes, and Strepticoccus mutans with maximum diameter of inhibition zone 10.30, 14.20, 9.60, and 15.10 mm, respectively.

Antimicrobial Activity of Sonneratia ovata Backer Laili Khumaidah; Adi Setyo Purnomo; Sri Fatmawati
HAYATI Journal of Biosciences Vol. 26 No. 4 (2019): October 2019
Publisher : Bogor Agricultural University, Indonesia

Sonneratia, a genus of mangroves from family Lythraceae, is reported for number of high biological activity including antimicrobial. Sonneratia ovata Backer is one of the species which traditionally used by Indonesian people for the treatment of some diseases. In this research, the investigation about biological activity of S. ovata Backer as anti-microbial has been performed. The methanol extract of S. ovata Backer is highly potential as antimicrobial against gram positive bacteria, S. aureus, with IC50 value of 7.7 μg/ml which is higher than of Ampicillin as positive control with IC50 value of 37.8 μg/ml. Furthermore, stigmasterol one of the major compound of S. ovata Backer has been isolated from the methanol extract of the stem bark of S. ovata Backer. Therefore, S. ovata Backer is proven to have high activity as antimicrobial, and highly potential to be a new source of antimicrobial agent.

Antibacterial and Toxicity Activities of Indonesian Herbal Medicine Extracts Used for Postpartum Treatment Wiwit Denny Fitriana; Sri Banun Titi Istiqomah; Devi Anggraini Putri; Taslim Ersam; Adi Setyo Purnomo Purnomo; Nurlatifah Nurlatifah; Sri Fatmawati
HAYATI Journal of Biosciences Vol. 28 No. 3 (2021): July 2021
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.28.3.232

Postpartum treatments have been used by local women in Indonesia for some time now. One commonly used postpartum treatment is the consumption of a traditional herbal medicine called PHM-1 during the first 40 days after childbirth. In addition, a second medicine known as PHM-2 is taken for days 41-80. However, sufficient scientific evidence about the benefits of this postpartum herbal medicine does not exist. In this study, the antibacterial abilities of PHM-1 and PHM-2 therefore was evaluated and showed positive potential for both. Low IC50 values were obtained against pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Rhodopseudomonas palustris, Ralstonia pickettii, and Staphylococcus epidermidis and compared with chloramphenicol as a positive control. The antibacterial activity of both PHM-1 and PHM-2 against R. pickettii had the highest inhibitory activity as evidenced by the lowest IC50 values of 11.16 and 6.26 μg/ml, respectively. Furthermore, an in vivo acute toxicity test showed that PHM-1 produced a low LD50 value of 3.28 g/kg BW for both of male and female mice. These results support the use of both PHM-1 and PHM-2 as antibacterial treatments for postpartum women.

Optimasi Kinerja Instalasi Pengolahan Air Limbah Industri Penyamakan Kulit Magetan Nastiti Sri Fatmawati
Jurnal Teknik ITS Vol 5, No 2 (2016)
Publisher : Direktorat Riset dan Pengabdian Masyarakat (DRPM), ITS

Industri Penyamakan Kulit Magetan terdapat 78 unit pengusaha penyamakan kulit. Produk kulit finish yang dihasilkan sebanyak ±8.2006.180.440 feet/tahun dan limbah cair yang dihasilkan hingga mencapai 1500 m3/hari. Industri Penyamakan Kulit Magetan telah dilengkapi dengan sarana IPAL dengan kapasitas 600 m3/hari. Hasil dari pemeriksaan parameter belum terpenuhinya baku mutu air limbah sesuai dengan PERGUB JATIM No. 72 Tahun 2013 Optimasi ini menggunakan metode evaluasi dan perhitungan optimasi. Evaluasi pertama yaitu menghitung efisiensi pengolahan dan proses pengolahan kemudian dari hasil evaluasi maka perlu melakukan perhitungan optimasi dari aspek teknis dan aspek biaya. Hasil evaluasi pengolahan biologis diperoleh nilai parameter sangat rendah, setelah di optimasi dengan merencanakan % efisiensi pengolahan dan penambahan debit air limbah didapatkan nilai MLSS pada bak aerasi 1 sebesar 1223 mg/l, bak aerasi 2 sebesar 774 mg/l, solid flux lumpur aktif 1 sebesar 1,17 kg/m2.hari, solid flux lumpur aktif 2 sebesar 0,6 kg/m2.hari, F/M rasio lumpur aktif 1 sebesar 0,08 kg BOD/kg MLSS, F/M rasio lumpur aktif 2 sebesar 0,1 kg BOD/kg MLSS, waktu detensi lumpur aktif 1 sebesar 2,5 jam, waktu detensi lumpur aktif 2 sebesar 2,8 jam, kebutuhan udara lumpur aktif 1 sebesar 121,5 m3/hari, dan kebutuhan oksigen lumpur aktif 2 sebesar 105 m3/hari. Hasil perhitungan optimasi biaya pemeliharaan menghabiskan dana sebesar Rp. 9.617.700,- per bulan.

Isolasi Senyawa Antioksidan dari Kulit Batang Sonneratia ovata Backer Fatati Nurmalasari; Taslim Ersam; Sri Fatmawati
Jurnal Sains dan Seni ITS Vol 5, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Campuran Senyawa β-sitosterol (1a) dan stigmasterol (1b) telah diisolasi dari ekstrak metanol kulit batang Sonneratia ovata Backer dengan titik leleh 127-128 oC. Sonneratia ovata Backer merupakan tumbuhan mangrove yang berasal dari Pulau Dobo, Kepulauan Aru, Maluku yang telah banyak digunakan sebagai obat tradisional untuk berbagai penyakit. Isolasi dilakukan dengan ekstraksi (maserasi) dan kromatografi cair vakum (KCV). Senyawa hasil isolasi dikarakterisasi dengan IR dan 13C-NMR. Fraksi dan senyawa hasil isolasi menunjukkan aktivitas antioksidan dengan uji radikal DPPH. Fraksi dan senyawa hasil isolasi menunjukkan aktivitas antioksidan yang lebih rendah dibandingkan dengan asam galat sebagai kontrol positif dengan persentase penghambatan sebesar 43,652 ± 0,013 % dan 27,159 ± 0,014% pada konsentrasi 319,458 µg/mL.

Isolasi Senyawa 3β-asetoksi-lup-20(29)-en-2-ol dan Uji Antioksidan dari Tumbuhan Kepulauan Aru (Sonneratia ovata Backer) Fatmawati Inneke Putri; Taslim Ersam; Sri Fatmawati
Jurnal Sains dan Seni ITS Vol 5, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Sonneratia ovata Backer merupakan salah satu tanaman yang berasal dari Kota Dobo, Kepulauan Aru. Senyawa 3β-asetoksi-lup-20(29)-en-2α-ol (1) berupa serbuk putih dengan titik leleh 200-201oC berhasil diisolasi dari ekstrak metanol kulit batang Sonneratia ovata Backer. Senyawa tersebut difraksinasi menggunakan metode kromatografi cair vakum (KCV) dan kromatografi kolom gravitasi (KKG). Senyawa murni diidentifikasi menggunakan spektroskopi IR, 1H-NMR, dan 13C-NMR. Uji bioaktivitas antioksidan dilakukan dengan metode DPPH. Fraksi dari senyawa (1) menunjukan prosentase penghambatan sebesar 20,91 ± 0,006 %.

Abstract of Invited Speaker : An Overview of Ganoderma lingzhi Constituents on α-Glucosidase and Aldose Reductase Inhibitory Activity Sri Fatmawati
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2015i1.1118

Ganoderma lingzhi is the medicinal woody mushroom which have been known to have hundreds bioactive compounds. The lanostane-type triterpenoids with carboxyl group in the side chain or known as ganoderma acids were isolated from the fruiting body of G. lingzhi. Some of these compounds were established as active inhibitors of α- glucosidase and human recombinant aldose reductase in vitro. The research objective is to enlighten the role of structural requirement of ganoderma acids both for α-glucosidase and aldose reductase inhibition. Comparing the inhibitory activity of these two enzymes, the structure–activity studies of ganoderma acids showed that the hydroxyl substituent at C-11 and the carboxylic group in the side chain are an important feature both for the recognition of α-glucosidase and human recombinant aldose reductase inhibitory activity. Furthermore, the double- bond moiety at C-20 and C-22 in the side chain and the hydroxyl substituent at C-3 of ganoderma acids enlarge the inhibitory activity of both enzymes. These outcomes offer an approach which to regard as the structural requirements of lanostane type triterpenoids acids from G. lingzhi. A consideration of these requirements is essential in order to develop a new type for substances that can be improved to prevent the diabetic complications

Isolation of Antioxidant Compounds from Mangiferaindica L. Leaves Fitria Fitria; Sri Fatmawati; Taslim Ersam
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2015i1.1155

The free radical scavenging activity of Mangiferaindica L. Leaves had been performed. The methanol extract showed the highest 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical scavenging activity among other extracts. Bioassay guided fractionation was performed and yielded three isolated compounds. Their structures were identified as mangiferin (1), friedelin (2) and lupeol (3). Mangiferin exhibited free radical scavenging activity, with an IC50 value of 12.12 µg/mL in vitro.

6β-hydroxyipolamiide of Stachytarpheta jamaicensis Leaves Yuliana Yuliana; Fithrotul Auwaliyah; Sri Fatmawati
IPTEK The Journal for Technology and Science Vol 30, No 3 (2019)
Publisher : IPTEK, LPPM, Institut Teknologi Sepuluh Nopember

Stachytarpheta jamaicensis is one species of Verbenaceae family that is used as a traditional medicine. 6β-hydroxyipolamiide is a natural occuring compound that was successfully isolated from S. jamaicensis leaves. The identification of compound was analyzed by using UV-Vis, Infra-Red (IR) spectrophotometry and Nuclear Magnetic Resonance (NMR) spectrometry. This is the first report that the compound has isolated from this plant.

Co-Authors Adi Setyo Purnomo Andy Wijanarko Arief Cahyanto Asih Rahaju Atmira Sariwati Devi Anggraini Putri Devi Anggraini Putri Devi Anggraini Putri Devi Anggraini Putri Dini Nur Fauzia Dwi Aprilia Anggraini Fadlan, Arif Fahimah Martak Fatati Nurmalasari Fatmawati Inneke Putri Fithrotul Auwaliyah Fitria Fitria Healthy Kainama Herdayanto Sulistyo Putro Inayah Fitri Kuniyoshi Shimizu Kuniyoshi Shimizu Laili Khumaidah Mardi Santoso Muchdar Soedarjo Mutia Devi Hidayati Myrna Nurlatifah Zakaria Novita Nugrahaeni Nur Hasanah Nurlatifah Nurlatifah Pieter Kakisina Putri Anni Maulida Rianur Oktavia RIYADATUS SOLIHAH Sri Banun Titi Istiqomah Suhartina Suhartina Taslim Ersam Wiwit Denny Fitriana Wiwit Denny Fitriana Yuliana Yuliana Yusfien Shabrina Putri

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