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All Journal HAYATI Journal of Biosciences Jurnal Teknik ITS Jurnal Sains dan Seni ITS IPTEK Journal of Proceedings Series IPTEK The Journal for Technology and Science The Journal of Pure and Applied Chemistry Research Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Chemistry Akta Kimia Indonesia NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN
Sri Fatmawati
Departemen Kimia, Institut Teknologi Sepuluh Nopember
Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : IPTEK Journal of Proceedings Series

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Abstract of Invited Speaker : An Overview of Ganoderma lingzhi Constituents on α-Glucosidase and Aldose Reductase Inhibitory Activity Sri Fatmawati
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2015i1.1118

Abstract

Ganoderma lingzhi is the medicinal woody mushroom which have been known to have hundreds bioactive compounds. The lanostane-type triterpenoids with carboxyl group in the side chain or known as ganoderma acids were isolated from the fruiting body of G. lingzhi. Some of these compounds were established as active inhibitors of α- glucosidase and human recombinant aldose reductase in vitro. The research objective is to enlighten the role of structural requirement of ganoderma acids both for α-glucosidase and aldose reductase inhibition. Comparing the inhibitory activity of these two enzymes, the structure–activity studies of ganoderma acids showed that the hydroxyl substituent at C-11 and the carboxylic group in the side chain are an important feature both for the recognition of α-glucosidase and human recombinant aldose reductase inhibitory activity. Furthermore, the double- bond moiety at C-20 and C-22 in the side chain and the hydroxyl substituent at C-3 of ganoderma acids enlarge the inhibitory activity of both enzymes. These outcomes offer an approach which to regard as the structural requirements of lanostane type triterpenoids acids from G. lingzhi. A consideration of these requirements is essential in order to develop a new type for substances that can be improved to prevent the diabetic complications
Isolation of Antioxidant Compounds from Mangiferaindica L. Leaves Fitria Fitria; Sri Fatmawati; Taslim Ersam
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2015i1.1155

Abstract

The free radical scavenging activity of Mangiferaindica L. Leaves had been performed. The methanol extract showed the highest 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical scavenging activity among other extracts. Bioassay guided fractionation was performed and yielded three isolated compounds. Their structures were identified as mangiferin (1), friedelin (2) and lupeol (3). Mangiferin exhibited free radical scavenging activity, with an IC50 value of 12.12 µg/mL in vitro.
Co-Authors Adi Setyo Purnomo Andy Wijanarko Arief Cahyanto Asih Rahaju Atmira Sariwati Devi Anggraini Putri Devi Anggraini Putri Devi Anggraini Putri Devi Anggraini Putri Dini Nur Fauzia Dwi Aprilia Anggraini Fadlan, Arif Fahimah Martak Fatati Nurmalasari Fatmawati Inneke Putri Fithrotul Auwaliyah Fitria Fitria Healthy Kainama Herdayanto Sulistyo Putro Inayah Fitri Kuniyoshi Shimizu Kuniyoshi Shimizu Laili Khumaidah Mardi Santoso Muchdar Soedarjo Mutia Devi Hidayati Myrna Nurlatifah Zakaria Novita Nugrahaeni Nur Hasanah Nurlatifah Nurlatifah Pieter Kakisina Putri Anni Maulida Rianur Oktavia RIYADATUS SOLIHAH Sri Banun Titi Istiqomah Suhartina Suhartina Taslim Ersam Wiwit Denny Fitriana Wiwit Denny Fitriana Yuliana Yuliana Yusfien Shabrina Putri