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All Journal Medula Jurnal Sinergitas PkM & CSR
Rani Himayani
Fakultas Kedokteran Universitas Lampung
Economics, Econometrics & Finance Education Environmental Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Efek Infeksi Virus SARS-CoV-2 Pada Organ Rani Himayani; Helmi Ismunandar; Aulia Khairunnisa; Gayitri Humaera; Meilisa Hidayah Putri; Novi Jayanti
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.178

Abstract

In December 2019, an outbreak of viral pneumonia caused by a novel coronavirus (since named SARS-CoV-2) was identified in Wuhan, China. Within few months, this disease known as coronavirus disease 2019 (COVID-19) spread worldwide, causing a global health emergency. The classic routes for transmission of SARS-CoV-2 are airborne droplets and surface contamination. The clinical presentation of COVID-19 ranges from asymptomatic infection to severe respiratory failure, with fever, fatigue, and cough occurring in most cases. The pathophysiology of SARS-CoV-2 infection is complex, endotoxin and tumor necrosis factor (TNF-α) trigger the production of interleukin (IL)-6 and IL-8, which is followed by a cytokine storm. Moreover, SARS-CoV-2 binds to angiotensin-converting enzyme-2 (ACE2) receptors, which are widely distributed not only in the lung alveolar epithelial cells and nasopharyngeal and oral mucosa but also in the endothelium and vascular smooth muscle cells, in the brain, in the gut, and in peripheral organs such as the liver and kidneys. This suggests that the clinical spectrum of COVID-19 is not limited to local pneumonia, but rather represents a multisystem illness with involvement of different organs and potential for systemic complications. Keywords:Covid-19, Angiotensin-converting enzyme, Multiple Organs.
PENINGKATAN PENGETAHUAN DAN SKREENING KELAINAN REFRAKSI DINI PADA ANAK USIA SEKOLAH DI NATAR LAMPUNG SELATAN [INCREASING THE KNOWLEDGE AND EARLY SCREENING OF REFRACTIVE ABNORMALITIES IN SCHOOL AGE CHILDREN AT NATAR LAMPUNG SELATAN] Rani Himayani; Soraya Rahmanisa
Jurnal Sinergitas PKM & CSR Vol 3, No 1 (2018): October
Publisher : Universitas Pelita Harapan

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Abstract

Background: Early detection of refractive abnormalities at late school age causes a decrease visual in children as a barrier in learning activities and carrying out daily activities, which can affect children's learning achievement. High refractive abnormalities that are not well corrected can cause lazy eyes in children. Objective: Increased knowledge and awareness of both children, parents and teachers regarding the importance of periodic control in children so that refractive abnormalities can be early detected at school age. Methods: screening of refractive abnormalities in children and eye examination by experts. Results: There were 56 children of Elementary School in South Lampung who were selected to attend counseling and eye screening. Based on data from pre-test observations, it was found that 61% of participants did not understand the knowledge of refractive abnormalities and 39% knew sufficient knowledge about refractive abnormalities. After counseling activities, the value of the observation results increases. Most participants understand about the knowledge of refractive disorders. The results of the screening for refraction abnormalities from 56 elementary school children found that 12 children experienced refractive error consisting of 3 boys and 9 girls. Children who detected refractive abnormalities were examined further and given treatment of prescription glasses. Conclusion: This program can help detect early if there are refractive abnormalities in school-age children so they can immediately get the treatment.
Co-Authors Aulia Khairunnisa Gayitri Humaera Helmi Ismunandar Meilisa Hidayah Putri Novi Jayanti Soraya Rahmanisa