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All Journal Althea Medical Journal Jurnal Ilmu Faal Olahraga Indonesia
Galuh Alviana
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Antidiabetic Activity of Calcium Bentonite in Alloxan Monohydrate-induced Diabetic Wistar Rat Models Galuh Alviana; Hendro Sudjono Yuwono; Nova Sylviana
Althea Medical Journal Vol 2, No 3 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.583 KB)

Abstract

Background: Calcium bentonite is a natural clay that has the ability to absorb toxins and metabolite excess substances and often referred to as healing clay because it is used traditionally. This study aimed to determine the ability of local calcium bentonite to absorp high blood glucose..Methods: This study was an experimental study using 20 female Wistar rats and divided into two groups consisting of Group I (control group, n=10) and Group II (calcium bentonite group, n=10). Diabetes in rats was induced by alloxan monohydrate 150 mg/kg body weight intraperitoneally. Examination of blood glucose was performed three times; in the beginning of study, 72 hours after alloxan monohydrate induction, and four days after the given interventions. Blood glucose levels in mean values were analyzed using t-independent test. Statistically significance was considered when p<0.05.Results: Oral calcium bentonite of 1g/kg body weight significantly lowered blood glucose level relatively to the control group with average value of 131.30 mg/dl (p=0.01).Conclusions: Calcium bentonite significantly lowers blood glucose levels. DOI: 10.15850/amj.v2n3.562
PENGARUH BENTONIT PER ORAL TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS MODEL DIABETES MELITUS YANG DIINDUKSI ALOKSAN MONOHIDRAT Galuh Alviana; Hendro Sudjono Yuwono; Nova Sylviana
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 3, No 2 (2020)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.372 KB) | DOI: 10.51671/jifo.v3i2.96

Abstract

In Indonesia, it is estimated that there would be increasing in number of diabetes mellitus patients become 12 million cases in 2030. The expensive cost of conventional medications motivates people to find alternative medication. Bentonite is a natural clay which is a good absorbent and frequently called as healing clay for its potency in body detoxification. This study is an experimental research to prove bentonite which is a good absorbent and adsorbent in decreasing blood glucose concentration in diabetes mellitus. Subject of this research is 20 female Wistar rats which weigh 150–250 g. These subjects were divided into two groups: control group and bentonite group. Diabetes is induced by alloxan monohydrate 150mg/kg intraperitoneally, causing β cell necrosis in pancreas. Result of independent t-test showed that bentonite could significantly lower blood glucose levels with average value of 131.30 mg/dL (p=0.010). This concludes that bentonite canreduce blood glucose level in diabetic-induced rats.
Co-Authors Hendro Sudjono Yuwono Nova Sylviana