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Adhi Djuanda
Department of Dermato-Venereology, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo Hospital, Jakarta.
Medicine & Pharmacology

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The role of HLA-antigens in Prurigo Hebra Boediardja, Siti A.; S, Moeslichan; Cornain, Santoso; Budimulja, Unandar; Djuanda, Adhi
Medical Journal of Indonesia Vol 9, No 4 (2000): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1133.994 KB) | DOI: 10.13181/mji.v9i4.616

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[no abstract available]
A retrospective study of patients with pemphigus during a five-year period, 1988-1992, in the Dr. Cipto Mangunkusumo Hospital, Jakarta Made Citrarasmi, A.A.A.; Djuanda, Adhi
Medical Journal of Indonesia Vol 3, No 3 (1994): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (670.906 KB) | DOI: 10.13181/mji.v3i3.965

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[no abstract available]
Tuberculosis verrucosa cutis with bilateral pulmonary tuberculosis Wardhani, Tina; Djuanda, Adhi; Sularsito, Sri A.
Medical Journal of Indonesia Vol 3, No 2 (1994): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (499.152 KB) | DOI: 10.13181/mji.v3i2.952

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[no abstract available]
The immunohistopathological features of prurigo Hebra Boediardja, Siti A.; Tjarta, Achmad; Cornain, Santoso; Budimulja, Unandar; Djuanda, Adhi; Roostini, Endang S.; Hartati, Meny
Medical Journal of Indonesia Vol 10, No 1 (2001): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1308.599 KB) | DOI: 10.13181/mji.v10i1.1

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Until now the pathologic mechanisms of prurigo Hebra (PH) is still understood. Earlier study the genetic inheritance of PH showed the multifactorial pattern. Considering the genetic inheritance and the existence of allergic reaction to insects bite in all patients, might be the mechanisms followed hypersensitivity reactions. The purpose of this study is to evaluate the general and specific local inflammatory features of early and late lesions of prurigo Hebra (PH). Fifty biopsy specimens of early and late lesions of prurigo Hebra patients were processed with haematoxylin-eosin (HE) and immunoperoryde (lP) staining using monoclonal antibodies against specific inflammatory cells namely B cells, T cells, helper T (CD4+) cells, supressor T (CD8+) cells, Langerhans cells, and antigen presenting cells (APC) that expressed HLA-DR antigen. HE-stained specimens: In early lesions, PMN cells were few, while eosinophils were present in great quantity and independent of mast cells and plasma cells; this feature was similar to that of insect bite reaction. IP-stained specimens: In late lesions, the amounts of lympho-histiocytic infiltration consisting of T cells, CD8+ cells, HLA-DR-expressing APCs were greater than those of early lesions, although it was not statistically significant. An exception was for the CD4+ cells, whose number in early lesions was significantly higher. The ratio of CD4+ to CD8+ in early lesions was higher than in late lesions (3/1: 2/1). This suggested that CD4+ cells were predominant. B cells, which were normally absent, appeared in small quantity in both early and late Lesions. The presence of B cells was not statistically correlated with T cells or eosinophils. The number of Langerhans cells in late lesions was higher than in early lesions. There was a strong correlation (r=0.39) between T cells and HLA-DR-expressing antigen-presenting cells (APCs/HLA-DR). Those cells found in great qunntity suggested that PH patients usually expose to extrinsic factors. In some cases with severe condition, the presence of eosinophils was more profound and was statistically significant. It is conclude that  immunohistopathological mechanisms of PH follow the mixed types (one and IV) hypersensitivity reaction. (Med J Indones 2001;10:1-15)Keywords: Prurigo Hebra, eosinophils, CD4+cells, mixed (I and IV) types of hypersensitivity.
Evaluation of the treatment of toxic epidermal necrolysis during a ten-year period, from 1982 to 1991, with corticosteroids as the main therapy Djuanda, Adhi
Medical Journal of Indonesia Vol 1, No 3/4 (1992): July-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1352.903 KB) | DOI: 10.13181/mji.v1i3/4.3619

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[no abstract available]
Co-Authors A.A.A. Made Citrarasmi Achmad Tjarta Endang S. Roostini Meny Hartati Moeslichan S Santoso Cornain Siti A. Boediardja Sri A. Sularsito Tina Wardhani Unandar Budimulja