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All Journal Kesmas: Jurnal Kesehatan Masyarakat Nasional Pharmascience JSFK (Jurnal Sains Farmasi & Klinis) Manuju : Malahayati Nursing Journal Medical and Health Science Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Rika Yulia
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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REVIEW ARTICLE: DEVELOPEMENT AND USING DENGUE VACCINE FOR DENGUE INFECTION VIRUS Firdaus Kabiru Massey; Rika Yulia
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1194

Abstract

Abstract : Tropical and subtropical countries are regions with high incidence of dengue infection. Dengue virus infection is estimated to cause 300 million new infections in one year and approximately 1 million severe cases with 2 + 5% deaths. The case of dengue in Indonesia has continued to increase since 1968 until 1980 where all provinces in Indonesia have been affected by the dengue virus. Dengue virus is a virus carried by the Aedes aegypti mosquito in its salivary gland. The virus which is a family group of Flaviviruses has four homologous serotypes, namely DENV-1, DENV-2, DENV-3, and DENV-4, which can cause dengue infection in individuals. Currently there is a shift in the target population from children to adults. This is a problem that needs to be resolved by the government and the community itself. Solution to overcome this, the government needs early prevention efforts to reduce the severity of dengue infection by developing and researching dengue vaccines. Currently a vaccine has been found that can be used as prophylaxis for dengue virus, namely Dengvaxia. This vaccine has been recommended by the World Health Organization (WHO) as prophylaxis for dengue infection, but Dengvaxia is only used in areas that are very endemic to dengue fever. The Indonesian Food and Drug Supervisory Agency (BPOM RI) has also approved the use of Dengvaxia as an indication of prevention of dengue infection since August 31, 2016. This vaccine has been approved globally only given to individuals aged between 9-16 years. Keyword : dengue virus, dengvaxia vaccine, Aedes aegypti, endemic
Correlation of Knowledge and Beliefs to Adherence with Antibiotic Use in Adult Patients at a Private Hospital in Sidoarjo Muhammad Hasan Wattiheluw; Fauna Herawati; Setiasih Setiasih; Rika Yulia
Jurnal Kesehatan Masyarakat Nasional Vol 15, No 2 (2020): Volume 15, Issue 2, May 2020
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1064.824 KB) | DOI: 10.21109/kesmas.v15i2.2409

Abstract

Infectious diseases are one of the top ten causes of death in the world. Antibiotic therapy is administered for infectious diseases, but if bacteria are exposed to antibiotics continuously, then the bacteria are able to adapt to the medication, thereby resulting in antibiotic resistance. This condition results in an increase in mortality, long hospitalization period, and increased cost of antibiotic therapy and health services. Adherence to using antibiotics may be influenced by knowledge and beliefs about them. This study aimed to understand correlation between knowledge and belief with adherence to antibiotic use at a private hospital in Sidoarjo. This cross-sectional study, the data collected in three months period, was conducted with a questionnaire for assessment knowledge and belief. A pill count method was applied for assessment adherence to using antibiotics prescribed by doctors. The study results show that knowledge of the respondents was adequate for 76 people (69.7%), belief was adequate for 74 people (67.9%), and adherence to antibiotic use for 79 people (72%). Regression analysis showed that the variable that significantly influenced the adherence of patients in using antibiotics was perceived threat (p-value = 0,029). Sex, age, education, income, occupation, and marital status have no contribution to antibiotic knowledge, belief, and adherence.
Evaluasi Penggunaan Antibiotik pada Pasien Bedah Bersih Terkontaminasi di Rumah Sakit Bhayangkara Surabaya Nurul Akhirin Nisak; Rika Yulia; Ruddy Hartono; Fauna Herawati
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.10107

Abstract

Bedah bersih terkontaminasi merupakan prosedur bedah yang dilakukan pada traktus bilier, traktus urinarius, respiratorius dan digestif, reproduksi kecuali ovarium atapun operasi tanpa disertai kontaminasi yang nyata. Bedah bersih terkontaminasi memiliki potensi terjadinya infeksi sebesar 3-11% untuk mencegah dan mengatasi terjadinya infeksi diperlukan pemberian antibiotik. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik dalam satuan Defined Daily Dose (DDD)/100 patient-days pada pasien bedah bersih terkontaminasi di RS Bhayangkara Surabaya. Metode penelitian dilakukan secara retrospektif observasional pada pasien rawat inap bedah dalam periode 1 Januari-31 Desember 2020. Hasil penelitian didapatkan 40 data medis kesehatan pasien yang memenuhi kriteria inklusi dan eksklusi. Total nilai DDD/100 patient-days antibiotik profilaksis tertinggi adalah ceftriaxone 25 DDD/100 patient-days, sedangkan antibiotik terapi yang paling tinggi adalah amoxicillin 38,35 DDD/100 patient-days. Antibiotik yang termasuk dalam segmen DU 90% pada penggunaan antibiotik profilaksis adalah ceftriaxone, cefazolin, dan amoxicillin; sedangkan untuk antibiotik terapi adalah amoxicillin, ceftriaxone, metronidazole, dan cefadroxil. Kesimpulan dari penelitian ini adalah penggunaan antibiotik pada bedah bersih terkontaminasi tinggi dan jenis antibiotik yang paling banyak digunakan adalah antibiotik golongan sefalosporin generasi 3 (ceftriaxone) yang spektrum antibakterinya lebih luas daripada antibiotik golongan sefalosporin generasi 2 (cefazolin).Kata Kunci: DDD/100 patient-days, Bedah Bersih Terkontaminasi, AntibiotikClean-contaminated surgery is a surgical procedure performed on the biliary tract, urinary tract, respiratory and digestive tracts, reproduction except for the ovaries or surgery with no contamination encountered. This procedure has a potential infection in the range of 3-11%, therefore it is necessary to give antibiotics to prevent and treat the possibility of infections. This study was to evaluate the use of antibiotics using the Defined Daily Dose (DDD)/100 patient-days in clean-contaminated surgical patients at Bhayangkara Hospital Surabaya. Data was collected retrospectively observational in surgical inpatients from 1st January-31st December 2020. Total samples 40 met the inclusion and exclusion criteria. The highest total DDD prophylactic antibiotic value was ceftriaxone 25 DDD/100 patient-days. On the other hand, the highest therapeutic antibiotic was amoxicillin 38.35 DDD/100 patient-days. The antibiotics included in the 90% DU segment in the use of prophylactic antibiotics were ceftriaxone, cefazolin, and amoxicillin. Meanwhile, for therapeutic antibiotics, namely amoxicillin, ceftriaxone, metronidazole, and cefadroxil. The use of antibiotics in clean surgery is high and the type of antibiotic that is most widely used is the third generation cephalosporin antibiotic (ceftriaxone) whose antibacterial spectrum is wider than the second generation cephalosporin antibiotic (cefazolin).
An Assay of Antioxidant Power of Methanolic Extract Various Type of Soybean Rika Yulia; Azminah Azminah; Michella Michella; Andre Tanzil
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (960.87 KB) | DOI: 10.29208/jsfk.2015.1.2.28

Abstract

This study aimed to examine the antioxidant activity of methanolic extract of various type of soybean (Glycine max L.Merill) i.e Argomulyo, Burangrang, Ijen, and Kaba by using DPPH (1,1-Diphenyl-2-picryhydrazyl) method. The soybean was crushed, defatted using n-hexan, and extracted using methanol 90%. The processes of defatting and extracting were conducted by kinesthetic maceration. Identification of flavonoid content using KLT and an assay of the antioxidant power of soybean were carried out qualitatively and quantitavely. Qualitative analysis, the color of DPPH solution was fading from violet into yellowish. Quantitative analysis showed that the maximum wave-length of DPPH in methanol was 516,00 nm within 15-minute reaction time. The effective concentration 50% (EC50) of each extract was alsa determined. Results of this study revealed that the methanolic extract of soybean taken from varieties of Argomulyo, Burangrang, Ijen, and Kaba contained flavonoid, with EC50 value of each variety subsequently ranging from 3620.22 bpj; 5290.71 bpj; 4145.99 bpj; and 4253.50 bpj. Argomulyo variety showed the highest antioxidant power.
Profil Penggunaan Obat pada Pasien Covid -19 di Ruang Isolasi Rumah Sakit X Kabupaten Malang Retno Juwita Sari; Rika Yulia; Fauna Herawati
Malahayati Nursing Journal Vol 4, No 11 (2022): Volume 4 Nomor 11 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v4i11.7169

Abstract

ABSTRACT Respiratory tract infections in early 2020 increased drastically due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Up to this point, therapy for this infection is referring to SARS-CoV-1 and MERS-CoV infections. Implementing secure and effective treatment for COVID-19 is indispensable. Drug repurposing/ drug reuse is a process to identify new indications of existing drugs. WHO recommends to optimize supportive care to support the main therapy in treating COVID-19.Objective of the study is to describe drug usage during COVID-19 pandemic. This study is observational, on adult subjects with confirmed COVID-19, with moderate to severe level of disease, data of whom was collected retrospectively during the period of April – March 2021. The findings reported 212 patients were treated as sample of the study, most of whom were male (50.9%). The highest age group was 56 – 65 years old by 27.4%. Frequent clinical symptoms were cough and shortness of breath; the highest profile of drug usage was supplement; and outcome for discharge improvement by 85.3%. Keywords: COVID-19, Drug Profile, Hospitalization, Outcome  ABSTRAK Kasus infeksi saluran pernafasan awal tahun 2020 meningkat secara drastis disebabkan oleh virus  Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Hinggga saat ini terapi yang digunakan mengacu dari pengobatan infeksi SARS-CoV-1 dan MERS-CoV. Kebutuhan pengobatan COVID-19 yang aman serta efektif sangatlah penting. Drug repurposing/ penggunaan obat kembali merupakan proses untuk mengidentifikasi indikaasi baru dari obat yang telah ada. WHO merekomendasikan perawatan suportif tetap dioptimalkan untuk menunjang terapi utama dalam pengobatan COVID-19. Penelitian ini bertujuan untuk mendiskripsikan penggunaan obat dimasa pandemik COVID-19. Penelitian ini merupakan penelitian observasional dengan pendekatan secara cross sectional,pada subyek dewasa yang terkonfirmasi COVID-19 derajat penyakit sedang hingga berat dengan pengambilan data penelitian secara retrospektif selama periode April 2020 – Maret 2021. Hasil menunjukkan terdapat sampel penelitian sebanyak 212 pasien yang terbanyak laki-laki (50,9%).. Penelitian ini bertujuan mendiskripsikan profil penggunaan obat dimasa pandemik COVID-19. Penelitian ini merupakan penelitian observasional pada subyek dewasa yang terkonfirmasi COVID-19 derajat penyakit sedang hingga berat dengan pengambilan data penelitian secara retrospektif selama periode April 2020 – Maret 2021. Hasil menunjukkan terdapat sampel penelitian sebanyak 212 pasien yang terbanyak laki-laki (50,9%). Rentang usia tertinggi pada usia 56 – 65 tahun sebesar 27,4%. Gejala klinis yang sering timbul adalah batuk dan sesak, profil penggunaan obat terbanyak yaitu suplemen serta outcome pulang perbaikan sebesar 85,3%. Kata Kunci: COVID-19, Profil Obat, Rawat Inap, Outcome
STUDI EFEKTIVITAS DAN EFEK SAMPING FAVIPIRAVIR PADA PASIEN COVID-19 PNEUMONIA DI RUMAH SAKIT BHAYANGKARA SURABAYA Rika Yulia; Fauna Herawati; Klara Rosjuita Hima; Ruddy Hartono; Puri Safitri Hanum
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 2 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i2.1486

Abstract

Favipiravir's indication extended for COVID-19 disease. This background consideration is related to its mechanism of action or effectivity in some COVID-19 patients, with or without pneumonia. This research is a retrospective observational study and analysis descriptively. The research material is medical records of patients with COVID-19 pneumonia using favipiravir from December 2020-May 2021. A total of 33 samples obtained met the inclusion and exclusion criteria. Effectiveness was analyzed by calculating the percentage of COVID-19 pneumonia patients who only used favipiravir while they were being treated until the patient was discharged. The side effects were the number of COVID-19 patients who drug injury liver disease (AST and ALT increase more than three times upper limit) and neutrophenia. This study reported that favipiravir was effective in COVID-19 patients with pneumonia, seen from 78.79% of patients who only used favipiravir during treatment. There were no patients who had an increase in AST ALT >3×upper limit of normal, and only seven patients with neutropenia.
Co-Authors Andre Tanzil Azminah Azminah Fauna Herawati Fauna Herawati Firdaus Kabiru Massey Klara Rosjuita Hima Michella Michella Muhammad Hasan Wattiheluw Nurul Akhirin Nisak Puri Safitri Hanum Retno Juwita Sari Ruddy Hartono Ruddy Hartono Setiasih Setiasih