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All Journal As-syifaa Jurnal Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences
Bayu Putra
Fakultas Farmasi Universitas Muslim Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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UJI AKTIVITAS EKSTRAK ETIL ASETAT DAUN KAYU JAWA (Lannea coromandelic (Houtt.) Merr.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH (Rattus norvegicus) Bayu Putra; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.720

Abstract

Wound healing is a process of repairing skin and soft tissue when these organs are injured. One of the plants that are presumed to affect wound healing is Kayu Jawa (Lannea coromandelic (Houtt.) Merr.). This research aims to determine the healing effect of burns and the effective dose of ethyl acetate extract of Kayu Jawa’s leaves. The animal test that has been induced using a hot plate with temperature 100oC stuck at the back of mice were divided into 5 (five) groups. Group 1 Na.CMC as Negative control, Group 2 Lanakeloid-E as Positive control, Group III, IV, and V were extract ethyl acetate of Kayu Jawa’s leaves (Lannea coromandelic (Houtt.) Merr) with 3 dosage variations namely, 75 mg/kg, 150 mg/kg, and 300 mg/kg were given topically 2 times a day for 21 days. Then wound area measure using calipers. The group with 300 mg/kg dosage has the best effect for reducing wound area of burns, with statistical value not significantly different from the comparison group (Lanakeloid-E) with a percentage value of 84%.
UJI AKTIVITAS HIPOLIPIDEMIK EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) PADA TIKUS OBESITAS DENGAN PARAMETER TRIGLISERIDA Rizqi Nur Azizah; Bayu Putra; Rafika Tobis
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.235 KB) | DOI: 10.33096/jifa.v10i1.332

Abstract

Hypolipidemics a drug used to lower plasma lipid levels in the blood. This study aimed to examine the hypolipidemic activity of ethanol extract of purslane herb (Portulaca oleracea L.) against the triglyceride level reduction in obese mice. The purslane herb contains omega-3, flavonoids and hight ascorbic acid as a lowering of triglyceride levels in the blood. This study used 15 malerats divided into 5 groups. Group I (negative control) was given Na.CMC 1%, group II (positive control) was given Gemfibrozil, group III, IV, and V were given ethanol extract of purslane herb with dose of 100 mg/kgBW, 200mg/kgBW, and 300 mg/kgBW as therapy group. All the administration were done orally once a day for 16 days. The measurement of triglyceride level was performed on early triglycerides before induction, after induction and after therapy. Before therapy, the rats were given hight-calorie diet. The results showed that the ethanol extract of purslanes herb has activity as hypolipidemic in lowering trygliseride level in obese mice. From the statistic result of One-Way ANOVA followed by LSD test, it can be concluded that the ethanol extract of purslane herb of the dose 100 mg/kgBW provide the most effective hypolipidemic activity that triglyceride level is not significantly different from positive control group (p>0,05).
UJI TOKSISITAS EKSTRAK ETANOL UMBI TALAS (Colocasia esculenta L. Schoot ) DENGAN METODE BRINE SHRIMP LETHALITY TEST TERHADAP Artemia Salina Leach Bayu Putra; Said Asrul Adjmi Assagaf
As-Syifaa Jurnal Farmasi Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.46 KB) | DOI: 10.33096/jifa.v7i1.17

Abstract

The research of toxicity assay of Ethanol Extracts of Taro tubers (Colocasia esculenta L. Schott) have been conducted with the aim of determining the effects of toxicity and anticancer potential of ethanol extract of tubers of taro (Colocasia esculenta L. Schott) by Brine Shrimp Lethality Test method against Artemia salina Leach. Ethanol extract, made with concentrations of 0.1, 1, 10, 100, 1000, and 10000 µg/ml and for comparison with the drugs vincristine concentrations of 0.01, 0.1, 1, and 10 µg/ml. Negative control using sea water made with the same concentrations. Furthermore, each concentration 10 ml of sea water and then put 10 shrimp larvae. The treatment is done by 10 replication at each concentration. Observations were made after 24 hours of treatment by counting the number of dead larva. The observations calculated using probit analysis program, showed LC50 values with 95% confidence level is 33,997 µg/ml (7,970 µg/ml-151,231 µg/ml). And the results of a comparison of data from drug vincristine showed LC50 value is 0,398 µg/ml (0,259 µg/ml-0,624 µg/ml).
Potensi Ekstrak Etanol Daun Kelor (Moringa oleifera L.) dalam Menurunkan Kadar Asam Urat Tikus Putih Bayu Putra; Rizqi Nur Azizah; Andi Clara
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 2 No 2 (2019)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.827 KB) | DOI: 10.24252/djps.v2i2.11273

Abstract

Daun kelor (Moringa oleifera L.) memiliki potensi yang diduga dapat menurunkan kadar asam urat tikus putih (Rattus norvegicus). Penelitian ini bertujuan untuk menentukan dosis ekstrak etanol daun kelora yang dapat menurunkan kadar asam urat tikus putih. Penelitian ini menggunakan 15 ekor tikus putih yang dibagi menjadi 5 kelompok. Kelompok I sebagai kontrol negatif yang diberikan jus hati ayam dan kalium oksonat 250 mg/kgBB, kelompok II sebagai kontrol positif yang diberikan allopurinol 5 mg/kgBB, dan kelompok III, IV, dan V sebagai kelompok perlakuan yang diberikan ekstrak etanol daun kelor dengan dosis 70, 140, dan 280 mg/kgBB selama 7 hari. Berdasarkan pengukuran kadar asam urat akhir didapatkan ekstrak etanol daun kelor dapat menurunkan kadar asam urat tikus putih.
AKTIVITAS ANTIINFLAMASII EKSTRAK ETANOL BATANG WOLE WOE PADA TIKUS DENGAN METODE RAT HIND PAW EDEMA Safriani Rahman; Sitti Amirah; Fitriana Fitriana; Bayu Putra
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.961

Abstract

Inflammation is the natural protective response of the body to tissue damage brought on by toxic chemicals, microbiological organisms, or physical trauma. The purpose of this investigation is to find out how active the ethanol extract of Wole woe stem is and how much of it is needed to get results. This anti-inflammatory study was conducted on 15 rats using the rat hind paw edema method. The rats were divided into 5 groups: group I served as a negative control (Na.CMC), group II served as a positive control (diclofenac sodium 0.9 mg/kgBW), groups III, IV, V received doses of Wole woe stem ethanol extract ranging from 100 mg/kgBW to 400 mg/kgBW, respectively. Oral administration was used for all the test materials, and after an hour, each test animal received a subplantar injection of 0.1 milliliters of 1% carrageenan solution. A plethysmometer was used to take readings every hour for a period of eight hours to get an accurate reading of the volume of the rat’s foot. The collected test results were subjected to statistical analysis, in which a one-way ANOVA and a post hoc LSD test were used. According to the findings of the research that was carried out, it was discovered that an ethanol extract of Wole woe stems possessed anti-inflammatory action, and the most effective dose was found to be 400 milligrams per kilogram of body weight (mg/kgBW).
Co-Authors Andi Clara Fitriana Fitriana Rafika Tobis Rizqi Nur Azizah Safriani Rahman Safriani Rahman Said Asrul Adjmi Assagaf Sitti Amirah