Article Per Year (5 Year)
p-Index From 2019 - 2024
1.126
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Andreas Arie Setiawan
Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Diponegoro, Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Jurnal Kedokteran Diponegoro

 1 
THE DIFFERENCES IN TROPONIN I AND CK-MB VALUES IN ACUTE MYOCARDIAL INFARCTION PATIENTS WITH ST ELEVATION AND WITHOUT ST ELEVATION Paulus Rio Kurniawan; Andreas Arie Setiawan; Charles Limantoro; Ariosta Ariosta
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29601

Abstract

Background: Acute myocardial infarction includes STEMI and NSTEMI. In STEMI and NSTEMI, an increase in cardiac biomarkers especially troponin I and CK-MB are affected by the ischemic process. In STEMI thrombus blocks the entire artery lumen while in NSTEMI thrombus does not block the entire artery lumen. This can lead to different ischemic processes. Aim: To prove the differences in troponin I and CK-MB values in acute myocardial infarction patients with ST-elevation and without ST- elevation. Methods: An observational analytic study using a cross-sectional design was conducted between April and September 2020. The total sample of the study was 48 samples, consists of 25 samples with STEMI and 23 samples with NSTEMI. The normality test was analyzed using  Shapiro-Wilk test. The difference test was analyzed using Mann-Whitney test. Results: Mean troponin I values of STEMI and NSTEMI patients were 30.40 ± 20.79 ng/mL; 1.38 ± 1.76 ng/mL, respectively. Mean CK-MB values in STEMI and NSTEMI patients were 386.12 ± 319.70 U/L; 42.39 ± 27.54 U/L, respectively. There were statistically significant differences in troponin I and CK-MB values (p respectively 0.00; 0.00) in STEMI patients compared to NSTEMI patients. Conclusion: There were differences in troponin I and CK-MB values between STEMI and NSTEMI patients. The troponin I and CK-MB values in STEMI patients were higher than in NSTEMI patients.
Difference in Profiles of Oxidative Stress Marker (MDA) in STEMI and NSTEMI Kaninta Nuga Sekunda; Ariosta Ariosta; Charles Limantoro; Andreas Arie Setiawan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29673

Abstract

ABSTRACT Introduction: Acute Myocardial Infarction (AMI) results in necrosis of the myocardium due to blockage in the coronary artery. AMI is classified into two categories, STEMI and NSTEMI. AMI is a multifactorial condition closely related to the increase in production of reactive oxygen species (ROS). As the end product of lipid peroxidase, Malondialdehyde (MDA) is often used as a biomarker for oxidative stress. Purpose: To prove the difference between profiles of oxidative stress marker (MDA) in STEMI and NSTEMI. Methods: An observational analytic study with a cross-sectional study approach done in Dr. Kariadi Central Public Hospital and Diponegoro National Hospital, Semarang, Central Java, between April and September 2020. Subjects were diagnosed by the presence of chest pains and an increase in CKMB and troponin levels. The study was conducted on 47 subjects consisting of 20 STEMI samples and 27 NSTEMI samples. Serum MDA was examined using the TBARS method. Data were analyzed by a computer program. Results: Mean serum MDA in STEMI and NSTEMI was 0,22 ± 0,12 μmol/L and 0,82 ± 0,92 μmol/L respectively. From the statistical analysis, results showed that the difference in serum MDA concentrations between STEMI and NSTEMI were significant (p = 0,007). Conclusion: Malondialdehyde concentration in NSTEMI was significantly higher than in STEMI. It is suggested that further research be done to know which type of MDA is more accurate, to understand the effect of lipid profile towards STEMI and NSTEMI, and to put patient’s medical history into consideration. Key Words: Acute Myocardial Infarction, Reactive Oxygen Species, Oxidative Stress, Malondialdehyde
Co-Authors Ariosta Ariosta Ariosta Ariosta Banundari Rachmawati Charles Limantoro Charles Limantoro Dwi Retnoningrum Fairuz Azmila Purnomo Hafidh Bagus Aji Prasetyo Jessica Christanti Kaninta Nuga Sekunda Lisyani Budipradigda Suromo M Yamin Mabruratussania Maherdika Marulam Panggabean Noor Wijayahadi Nyoman Suci Widiastiti Paulus Rio Kurniawan Purwanto Adhipireno Raden Mas Soerjo Adji Setyo Gundi Pramudo Siti Setiati Vega Karlowee