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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Andreas Arie Setiawan
Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Diponegoro, Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of Biomedicine and Translational Research

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The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats Andreas Arie Setiawan; Fairuz Azmila Purnomo; Vega Karlowee; Noor Wijayahadi
Journal of Biomedicine and Translational Research Vol 7, No 2 (2021): August 2021
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v7i2.11686

Abstract

ABSTRACTBackground: Obesity is a disorder or disease characterized by the accumulation of excess fat in the body due to an imbalance in energy intake that is used for a long time. Accumulation of fat can reduce adiponectin, causing cardiac hypertrophy, endothelial vasodilation, and other cardiovascular diseases. Black garlic have high antioxidants in the form of S-Allylcysteine(SAC) which functions to increase adiponectin. Objective: To determine the effect of Black garlic on the histopathological picture of the heart and aorta of obese rats. Methods: This study was an experimental study with a randomized post-test only design with control group design with 5 groups of male white rats Sprague Dawley (Rattus novergicus) fed High Fat Fructose. Diet (HFFD) enriched with 1.25% cholesterol and 0.5% cholic acid for 8 weeks and was given black garlic intervention at doses of 450 mg / 200BW, 900mg / 200BW and 1350mg200 / BW for 4 weeks. Results: Giving black garlic significantly reduced body weight of rats (p = 0.001), and the results did not significantly reduce heart weight (p = 0.147), aortic weight (p = 0.061), histopathological changes in heart wall thickness (p = 0.423) and aortic wall thickness (p = 0.802). The effective doses of black garlic in this study were 450 mg / 200 grams BW, 900 mg / 200 grams rat BW and 1350 mg / 200 grams BW of rats. The optimal dose is 900 mg / 200 grams BW. Conclusion: Black garlic gave a significant reduction in body weight of rats and no significant reduction in heart weight, aortic weight, cardiac and aortic histopathological features. 
Co-Authors Ariosta Ariosta Ariosta Ariosta Banundari Rachmawati Charles Limantoro Charles Limantoro Dwi Retnoningrum Fairuz Azmila Purnomo Hafidh Bagus Aji Prasetyo Jessica Christanti Kaninta Nuga Sekunda Lisyani Budipradigda Suromo M Yamin Mabruratussania Maherdika Marulam Panggabean Noor Wijayahadi Nyoman Suci Widiastiti Paulus Rio Kurniawan Purwanto Adhipireno Raden Mas Soerjo Adji Setyo Gundi Pramudo Siti Setiati Vega Karlowee