Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Kedokteran Meditek
Daniel Mahendra Krisna
Duta Wacana Christian University
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
AKURASI PENINGKATAN PROSTATE-SPECIFIC ANTIGEN DALAM DARAH TERHADAP KEGANASAN PROSTAT Daniel Mahendra Krisna; Hariatmoko Hariatmoko; Rizaldy Taslim Pinzon
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 1, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss1.art5

Abstract

Background: Various controversies arose in the study of PSA examination as an alternative of biopsy to detect prostate malignancy. Prostate Specific Antigen (PSA) is a specific protein secreted by the prostate gland and is affected by various conditions. PSA levels will certainly increase at the enlargement of the prostate gland. An accurate cutoff point that can detect prostate cancer is needed.Objective: To evaluate the PSA diagnostic test against prostate malignancy.Methods: This study used a diagnostic test method for 91 patients undergoing either prostate gland surgery or open prostatectomy at Bethesda Hospital Yogyakarta in January 2014-January 2016 period. Data were taken from medical records with inclusion criteria as follow: over 50 years of age, preoperative PSA, and PA results. This study was a descriptive analytic study. In the diagnostic test AuROC, cutoff points were determined. Chisquare test was performed to assess sensitivity, specificity, PPV, NPV, LHR -, and LHR +.Results: We studied 91 patients with a mean age of 70.24 ( 46-54 ) and mean PSA level of 27.2 ( 0.59-101 ). The results of PA prostate tissue examinations were adenocarcinoma in 15 patients ( 16.5 % ) and BPH in 76 patients ( 83.5 %) On all PSA levels, AuROC were 0.90. Specificity of PSA with 4 ng / mL cutoff, 10 ng / mL, 20 ng / mL, 50 ng / mL, and 100 ng / mL were 0.53, 35.53, 67.11, 96.05, 98.68. When the cutoffs were reduced to 4.01-10ng/mL, 10.01-20 ng/mL, 20.01-50ng/ mL,50.01-100 ng/mL, and > 100 ng/mL, the specifity were 76.32, 68.00, 69.74, 96.05, 100.00. Cutoff value of 50ng / mL had LHR + >10.00 ( 15:20 ).Conclusion: There is a strong correlation between PSA and prostate malignancy. PSA value> 50 ng / mL has high accuracy to detect prostate malignancy. A biopsy is needed to determine a definitive diagnostic because no cutoff value can be used as a benchmark.
Terapi Injeksi Botulinum Sebagai Tatalaksana Overactive Bladder Daniel Mahendra Krisna
Jurnal Kedokteran Meditek VOL. 24 NO. 65 JANUARI-MARET 2018
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v24i65.1353

Abstract

Overactivity Bladder (OAB) adalah kelainan yang berkaitan dengan adanya gangguan berkemih, baik disertai dengan inkontinensia atau tidak, dengan dibuktikan tidak ada infeksi atau kelainan patologis yang mendasari. OAB sangat mengganggu kualitas hidup penderita dan dapat mengenai berbagai usia. Tatalaksana OAB meliputi terapi perilaku dan medikamentosa sebagai lini pertama. Ketidakpatuhan penderita dan efek samping yang terjadi memberikan angka kegagalan yang tinggi. Injeksi botulinum yang mempunyai mekanisme kerja menghambat pelepasan neurotransmitter, sehingga menurunkan kontraksi otot polos, dapat dipertimbangkan sebagai tatalaksana lini pertama.
Co-Authors Hariatmoko Hariatmoko Rizaldy Taslim Pinzon