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All Journal Damianus Journal of Medicine Indonesian Journal of Tropical and Infectious Disease JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Freggy Spicano Joprang
Department Of Parasitology, School Of Medicine And Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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PERBANDINGAN DAYA BIOLARVASIDA EKSTRAK BIJI BUAH DAN DAUN PEPAYA (Carica papaya) TERHADAP LARVA Aedes aegypti Fidel Corona; Freggy Spicano Joprang
Bahasa Indonesia Vol 18 No 1 (2019): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v18i1.2193

Abstract

Introduction: Aedes aegypti is the major vector of dengue virus. Dengue virus can cause dengue hemorrhagic fever (DHF). DHF is dangerous because it can cause death. World Health Organization (WHO) noted Indonesia as state with the highest dengue cases in Southeast Asia. Effort to control A. aegypti vector that can be done is by using natural substances that have the effect of biolarvicides. This study aims to determine natural biolarvicides potencial of fruit seeds and leaf papaya (Carica papaya) extracts against A. aegypti larvae. Methods: This study was an experimental study and conducted in 2016 using two groups of samples with the design before and after intervention. Samples were A. aegypti larval instar III and IV with the number of 10 larvaeper concentration and 10 larvae of control for each types of extracts. The concentration used was 0 mg / L (control), 50 mg / L, 100 mg / L, and 150 mg / L for both types of extracts, then observed at 6 hours, 12 hours, 18 hours, and 24 hours after exposure. Results: This study using Kruskal Wallis test, p value = 0.352. (P> 0.05) means there is no significant difference in the effect of biolarvicides concentration between the two types of extracts that used to the number of dead larvae of A. aegypti. Conclusion: Fruit seeds and leaf papaya extracts (C. Papaya L.) with concentrations of 50 mg / L, 100 mg/ L, and 150 mg / L are not effective to kill the larvae of A. aegypti. Other studies show concentrations above 21.9 ppm of leaf extract and 442 ppm of fruit seed extract can effectively kill larvae, therefore future studies are needed to determine effective extract concentrations to kill the larvae of A. aegypti.
Plasmodium falciparum Breath Metabolomics (Breathomics) Analysis as a Non-Invasive Practical Method to Diagnose Malaria in Pediatric Ignatius Ivan; Maureen Miracle Stella; Kevin Tandarto; Fanny Budiman; Freggy Spicano Joprang
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.24069

Abstract

Children under 5 years of age are particularly vulnerable to malaria. Malaria has caused 445,000 deaths worldwide. Currently, rapid diagnostic tests (RDTs) are the fastest method to diagnose malaria. However, there are limitations that exist such as low sensitivity in detecting infections with low parasitemia. Practical, non-invasive and high ability tests to detect parasite are needed to find specific biomarkers for P. falciparum infection to determine the potential of P. falciparum 4 thioether in breathomics analysis by GC-MS as a practical non-invasive method in diagnosing malaria in pediatrics. Literature reviews from Google Scholar and ProQuest were published no later than the last 5 years. The concept of breathomics is that the breath’s volatile organic compounds (VOCs) profile is altered when the health condition changes. Breath samples from individuals infected with P. falciparum malaria were taken by exhalation. Through GC-MS analysis, it was found that 4 thioether compounds (allyl methyl sulfide (AMS), 1-methylthio-propane, (Z) -1-methylthio-1-propene and (E) -1-methylthio-1-propene) underwent a significant change in concentration during the infection. Based on experiments conducted on mice and humans, the breathomics method is known to be able to detect parasitemia levels up to <100 parasites/µL, has a sensitivity level of about 71% to 91% and a specificity of about 75% to 94%. The discovery of 4 thioether compounds by GC-MS is a strong indication of malaria, because it has the potential for high sensitivity and specificity, and the detection power exceeds the ability of RDTs.
Diagnosis dan Tatalaksana Terkini Penyakit Neurosistiserkosis Michael Carrey; Endy Suseno; Freggy Spicano Joprang; Octavianus Darmawan; Rr. Josephine Retno Widayanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss3.art9

Abstract

Cysticercosis occurs in porcine naturally. A human can be infected by cysticercosis if they swallow Taenia solium's egg inadvertently. These eggs can be found in vegetables or unboiled water. These eggs hatch and later will become larva that becomes cysts in muscle or brain, known as cysticercus cellulose. Neurocysticercosis is an infection of the central nervous system caused by Taenia solium at its larval stage. Indonesia is a developing country with a high incidence rate of neurocysticercosis, with the highest amount of cases found in Bali and Papua. Neurocysticercosis boasts a broad array of clinical symptoms, from silent disease to a severe, debilitating illness that leads to death. The diagnosis of neurocysticercosis itself presents a great challenge, due to the unspecific clinical symptoms, in-pathognomonic radiographic findings and serologic studies with low specificity and sensitivity. The management of neurocysticercosis consists of a combination of antiparasitic agents and supportive therapies, ranging from steroid to surgeries that can be done under certain circumstances.
Co-Authors Endy Suseno Fanny Budiman Fidel Corona Ignatius Ivan Kevin Tandarto Maureen Miracle Stella Michael Carrey Octavianus Darmawan Octavianus Darmawan Rr. Josephine Retno Widayanti