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All Journal Jurnal Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar
Afrisusnawati Rauf
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PENENTUAN AKTIVITAS MINYAK DAUN NILAM (Pogostemon cablin Benth) TERHADAP PENYEMBUHAN LUKA SAYAT PADA MENCIT JANTAN (Mus musculus) Faridha Yenny Nonci; Afrisusnawati Rauf; Nur Afdhaliah
Jurnal Kesehatan Vol 10 No 2 (2017): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i2.4388

Abstract

Kerusakan jaringan tubuh dapat disebabkan oleh beberapa hal. Luka sayat merupakan suatu bentuk kerusakan atau kehilangan jaringan tubuh yang disebabkan oleh benda tajam. Aktivitas penyembuhan luka dapat ditemukan pada kandungan senyawa yang terdapat pada daun nilam yaitu minyak nilam yang memiliki kandungan senyawa patchouli alcohol, tanin, saponin dan α-bulnasen. Penelitian ini bertujuan untuk mengetahui aktivitas minyak daun nilam (Pogostemon  Cablin Benth) dalam penyembuhan luka sayat, mengetahui  konsentrasi yang paling baik dan bagaimana  perspektif Islam tentang pemanfaatan daun Nilam (Pogostemon cablin Benth) sebagai obat penyembuh luka sayat. Penelitian ini menggunakan metode penelitian  eksperimental laboratorium. Subjek penelitian adalah mencit yang dibagi menjadi  menjadi 7 kelompok  perlakuan. Kelompok I, II, III, IV dan V  adalah kelompok ekstrak daun Nilam (Pogostemon Cablin Benth) dengan konsentrasi  berturut-turut 10%, 20%, 30%, 40%, dan 50%, kelompok VI Betadin (Povidon Iodin 10%) sebagai kontrol positif dan kelompok VII Tween 80 sebagai kontrol negatif.  Pemberian dilakukan secara topikal dengan volume pemberian 1 ml. Hasil penelitian ini menunjukkan bahwa ekstrak minyak daun Nilam (Pogostemon Cablin Benth) pada konsentrasi 10%, 20%, 30%, 40%, dan 50% dapat menyembuhkan luka sayat pada mencit (Mus musculus) dan pada konsentrasi  50% menunjukkan aktivitas terbaik dalam penyembuhan luka sayat.
AKTIVITAS PENGHAMBATAN FRAKSI DAUN DELIMA (Punica granatum L.) TERHADAP BAKTERI Mycobacterium tuberculosis Afrisusnawati Rauf; Nurshalati Tahar; Resnia Resnia
Jurnal Kesehatan The 1st Alauddin Pharmaceutical Conference and Expo (ALPHA-C) 2019
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v0i0.18044

Abstract

Punica granatum L., commonly known as pomegranate, has emerged as a medicinal plant with potential antimicrobial activity. This study aims to identify this activity against the bacteria Mycobacterium tuberculosis. Pomegranate leaf extract is made using solvents (ethanol 96%), then partitioned using n-butanol solvents and fractionated using vacuum liquid chromatography method. After obtaining the fractional results, the inhibitory activity effect of the fraction was studied using the Mycobacterium tuberculosis H37RV strain and compared to commercial antibiotic Isoniazid using the MODS method. Pomegranate leaf fraction shows antibacterial activity against Mycobacterium tuberculosis at a concentration of 1000 ppm, as seen from the absence of cord at such concentrations. Therefore this plant can be an important source of new antimicrobial compounds to treat the bacteria Mycobacterium tuberculosis.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN KELOR (MORINGA OLEIFERA L) TERHADAP PENURUNAN KADAR KOLESTEROL DARAH PADA MENCIT (MUS MUSCULUS) JANTAN Mukhriani Mukhriani; Nurlina Nurlina; Andi Nilan; Afrisusnawati Rauf
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 3 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i3.2121

Abstract

Test  of  efficacy studies  have  been  conducted  leaf  extract  (Moringa oleifera  L)  to decrease blood cholesterol levels in mice (Mus musculus) males. This study aims to determine the effectiveness of moringa leaf extract on reducing cholesterol in mice. In this study using 15 male mice were divided into 5 groups. Before being given treatment, mice were first fasted for 8 hours and then measured cholesterol levels initially. After that induced propylthiouracil every day on each mouse to raise the cholesterol levels of mice for 14 days. Furthermore, given the different treatments in each group for 14 days and total cholesterol levels were measured on day 28th Group I was given NaCMC 1% w / v as a negative control and the obtained yield was 150 mg / dL, 183 mg / dL and 254 mg / dl, group II was given a suspension Simvastatin as a positive control and the results obtained 136 mg / dL, 155 mg / dL, and 164 mg / dL, a group III, IV, and V are given extracts of leaves (Moringa oleifera L) with three variations of the dose 50 mg / g, 100 mg / g, 200 mg / g and the results obtained successively by 127 mg / dL, 135 mg / dL, 152 mg / dL, 170 mg / dL, 176 mg / dL, 188 mg / dL, 156 mg / dL, 137 mg / dL, 175 mg / dL. The results showed that the leaf extract of Moringa can lower total cholesterol levels of mice at a dose of 200 mg / g, but not as effective as simvastatin.
Efek Antihiperglikemik Fraksi-Fraksi Daging Buah Mengkudu (Morinda citrifolia L.) pada Tikus Putih Jantan Mukhriani Mukhriani; Afrisusnawati Rauf; Indah Purnamasari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 1 No 2 (2018)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.527 KB) | DOI: 10.24252/djps.v1i2.11409

Abstract

Penelitian efektivitas antihiperglikemik dari fraksi daging buah mengkudu (Morinda citrifolia L.) pada tikus putih jantan yang diinduksi dengan glukosa 50% telah dilakukan. Tujuan dari penelitian ini adalah untuk menentukan efek fraksi varian hasil daging buah mengkudu 1000 mg/kg BB terhadap tikus hiperglikemia. Kadar glukosa darah diukur 0, 30, 60, dan 90 menit setelah perlakuan. Penelitian menunjukkan bahwa fraksi A memiliki efek antihiperglikemik tertinggi dengan laju penurunan glukosa darah 55,77%, mirip dengan glibenclamide sebagai tikus kontrol positif dengan laju penurunan glukosa darah 60,06%.
Antiproliferation potential of Botto-botto (Chromolaena odorata L.) leaves methanol extract fraction against HeLa Cell Line Muhammad Rusdi; Haeria Haeria; Nursalam Hamzah; Afrisusnawati Rauf; Faradibha Amriani
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.14051

Abstract

Botto-botto (Chromolaena odorata L.) was one of plants that its leaves used empirically in South Sulawesi society as wound and anti-inflammatory drugs. This study aimed to determine the potential of Botto-botto toward cancer cells (HeLa Cells) and normal cells (Vero cells) using the MTT assay method (Microculture Tetrazolium Salt Method). Ethyl acetate extract from methanol extract being fractionated by vacuum liquid chromatography method by a different polarity level of solvent. Cytotoxic effect test was using MTT method to cancer cells (HeLa), and normal cells (Vero) with the percent parameter of cell growth inhibition. Selectivity index was determined from percentage of cancer cell growth inhibition ratio of cancer cells to normal cells. The results showed that A, B, C, D, E, F, and G fractions had a selectivity index on HeLa cells at 0.845, 3.387, 2.004, 1.508, 1.625, 1.284, 1.299. This result proved that B fraction of methanol extract of Botto-botto leaves had a potential to be developed as chemotherapy agents in increasing the effectiveness treatment of cervix cancer.
Co-Authors Andi Nilan Faradibha Amriani Faridha Yenny Nonci Haeria Haeria INDAH PURNAMASARI Isriany Ismail Mardan Muhammad Rusdi Mukhriani, Mukhriani Nur Afdhaliah Nurlina Nurlina Nursalam Hamzah Nurshalati Tahar Resnia Resnia