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All Journal Jurnal Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar
Afrisusnawati Rauf
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : ad-Dawaa : Journal of Pharmaceutical Sciences

 1 
Efek Antihiperglikemik Fraksi-Fraksi Daging Buah Mengkudu (Morinda citrifolia L.) pada Tikus Putih Jantan Mukhriani Mukhriani; Afrisusnawati Rauf; Indah Purnamasari
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 1 No 2 (2018)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.527 KB) | DOI: 10.24252/djps.v1i2.11409

Abstract

Penelitian efektivitas antihiperglikemik dari fraksi daging buah mengkudu (Morinda citrifolia L.) pada tikus putih jantan yang diinduksi dengan glukosa 50% telah dilakukan. Tujuan dari penelitian ini adalah untuk menentukan efek fraksi varian hasil daging buah mengkudu 1000 mg/kg BB terhadap tikus hiperglikemia. Kadar glukosa darah diukur 0, 30, 60, dan 90 menit setelah perlakuan. Penelitian menunjukkan bahwa fraksi A memiliki efek antihiperglikemik tertinggi dengan laju penurunan glukosa darah 55,77%, mirip dengan glibenclamide sebagai tikus kontrol positif dengan laju penurunan glukosa darah 60,06%.
Antiproliferation potential of Botto-botto (Chromolaena odorata L.) leaves methanol extract fraction against HeLa Cell Line Muhammad Rusdi; Haeria Haeria; Nursalam Hamzah; Afrisusnawati Rauf; Faradibha Amriani
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 2 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i2.14051

Abstract

Botto-botto (Chromolaena odorata L.) was one of plants that its leaves used empirically in South Sulawesi society as wound and anti-inflammatory drugs. This study aimed to determine the potential of Botto-botto toward cancer cells (HeLa Cells) and normal cells (Vero cells) using the MTT assay method (Microculture Tetrazolium Salt Method). Ethyl acetate extract from methanol extract being fractionated by vacuum liquid chromatography method by a different polarity level of solvent. Cytotoxic effect test was using MTT method to cancer cells (HeLa), and normal cells (Vero) with the percent parameter of cell growth inhibition. Selectivity index was determined from percentage of cancer cell growth inhibition ratio of cancer cells to normal cells. The results showed that A, B, C, D, E, F, and G fractions had a selectivity index on HeLa cells at 0.845, 3.387, 2.004, 1.508, 1.625, 1.284, 1.299. This result proved that B fraction of methanol extract of Botto-botto leaves had a potential to be developed as chemotherapy agents in increasing the effectiveness treatment of cervix cancer.
Co-Authors Andi Nilan Faradibha Amriani Faridha Yenny Nonci Haeria Haeria INDAH PURNAMASARI Isriany Ismail Mardan Muhammad Rusdi Mukhriani, Mukhriani Nur Afdhaliah Nurlina Nurlina Nursalam Hamzah Nurshalati Tahar Resnia Resnia