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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Molekul: Jurnal Ilmiah Kimia
Firster Nugroho
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Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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Formulasi Tablet Hisap Kombinasi Curcuma xanthoriza Roxb., Curcuma longa L., dan Zingiber officinale ‘Sunti’ Sebagai Sediaan Kemopreventif Kanker Setia D Wardhani; Firster Nugroho; Dwi Yulianto; Soffatul Azizah; Yogi Wahyono; Hendri Wasito
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 4 No 1 (2016): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.928 KB)

Abstract

Kanker adalah penyebab kematian terbesar kelima di dunia dan kasus baru muncul secara signifikan. Akhir-akhir ini, produk alami yang digunakan secara luas sebagai kemopreventive untuk kanker. Penelitian sebelumnya melaporkan Curcuma zanthorrhiza Roxb., Curcuma longa L. Dan Zingiber officinale 'Sunti' memiliki aktivitas antikanker yang diuji secara in vitro dan in vivo. Saat ini, penggunaan C. Zanthorrhiza Roxb., C. Longa L.and Z. Officinale 'Sunti'is masih terbatas oleh masyarakat. Sehingga dibutuhkan suatu sediaan yang lebih praktis dalam bentuk formulasi. Penelitian ini bertujuan untuk mempersiapkan tablet hisap dengan variasi bahan pengikat polivinilpirolidon (PVP), sehingga dihasilkan formula yang memenuhi syarat uji fisik tablet hisap serta dapat diterima oleh masyarakat. Ekstrak campuran disiapkan secara granulasi basah, sifat fisik dari uji yang dilakukan meliputi penampilan fisik, keseragaman bobot dan ukuran, uji kekerasan, uji kerapuhan, dan waktu larut dan dievaluasi berdasarkan persyaratan dalam Farmakope Indonesia edisi III dan edisi IV, data yang diperoleh kemudian dianalisis dengan uji statistik ANOVA. Data responsif uji rasa hasil oleh para responden dianalisis menggunakan Kruskal Wallis. Hasil uji statistik menunjukkan bahwa formulasi tablet hisap ekstrak dengan variasi dalam tingkat PVP 2-6% menunjukkan sifat fisik yang memenuhi syarat untuk tablet hisap.
Nigella Sativa’s Protection Against 7,12 Dimethylbenz [A] Anthracene -Induced Colon Carcinogenesis in Rats Heny Ekowati; Firster Nugroho; Iskandar Sobri
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.933 KB) | DOI: 10.20884/1.jm.2021.16.3.734

Abstract

Colon cancer is the third most common cause of death from cancer worldwide. Recently, natural products have been widely used as an alternative therapy for colon cancer. Previous studies have reported that Nigella sativa has chemopreventive activity in vitro and in vivo.This study aimed to evaluate the effect of Nigella sativa seed (NSS) on rat-colon cell after initiation of 7,12-dimethylbenz [a] anthracene. Rats were divided into five groups, 12 rats in each group: Group I was given 7,12dimetilbenz [a] anthracene (DMBA) orally 20 mg/kgBW twice a week for five weeks, group V is the solvent control group was given corn oil. The other three groups were given DMBA + NSS, at the dosage of 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW. NSS extract was dissolved in corn oil and administered daily per oral during the next two weeks before and during the initiation of DMBA. After 16 weeks, all rats were sacrificed. H&E staining showed that necrosis activity was lower in treated groups compared to DMBA group. AgNOR staining showed mAgNOR was significantly decrease following the increasing dose of NSS (250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) were subsequently 1.62 ± 0.086, 1.60 ± 0.101 and 1.39 ± 0.049 (p<0.05). The results showed that NNS reduce the damage of colon cells and inhibit colon cell proliferation in DMBA induced rats.
Co-Authors Dwi Yulianto Hendri Wasito Heny Ekowati Iskandar Sobri Setia D Wardhani Soffatul Azizah Yogi Wahyono