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All Journal International Journal of Public Health Science (IJPHS) Farmaka
Ajeng Diantini
Padjadjaran University
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Suplementasi Selenium Untuk Pencegahan Penyakit Jantung Felia Rizka Sudrajat; Ajeng Diantini
Farmaka Vol 17, No 3 (2019): Farmaka (Desember)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.537 KB) | DOI: 10.24198/jf.v17i3.22055

Abstract

Penyakit jantung menjadi penyebab utama kematian di Indonesia. Salah satu trace elements, yaitu selenium, memiliki fungsi biologis yang penting, diantaranya berperan dalam metabolisme hormon tiroid, mekanisme pertahanan tubuh sebagai antioksidan, dan pencegahan kanker. Sebagai antioksidan, selenium bekerja dengan selenoprotein yang memiliki peran terhadap pencegahan penyakit jantung, terutama glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs), dan selenoprotein R (SelR). Defisiensi selenium dalam tubuh dapat mengganggu fungsi biologisnya sebagai antioksidan. Suplementasi adalah salah satu cara untuk mencukupi kebutuhan selenium. Metode yang digunakan dalam penyusunan review artikel ini adalah systematic review dengan menggunakan database jurnal mutakhir dari PubMed, NCBI, dan Science Direct. Beberapa penelitian menunjukkan adanya hasil positif pada pasien penyakit jantung setelah suplementasi selenium. Dengan demikian, suplementasi selenium memiliki potensi sebagai upaya pencegahan penyakit jantung, namun diperlukan studi eksperimental lebih lanjut untuk menjamin keamanan dan efikasi jangka waktu panjang.Kata kunci: penyakit jantung, selenium, suplementasi, pencegahan
Modified pharmacy counseling improves outpatient short-term antibiotic compliance in Bali Province I Gusti Ayu Rai Widowati; Dyah Pradnyaparamita Duarsa; Ni Nyoman Sri Budayanti; Ajeng Diantini; Pande Putu Januraga
International Journal of Public Health Science (IJPHS) Vol 11, No 3: September 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i3.21537

Abstract

Pharmacy counseling, which provides quality drug information, improves patient safety. However, this service is not optimally provided in Indonesia. A new model, modified pharmacy counseling (MPC), was developed to make it easier for service providers. We aimed to measure MPC effectiveness in improving short-term antibiotic compliance. This community trial (ISRCTN82062391) involved patients (age, ≥18 years) recruited from selected pharmacies between December 2020 and February 2021 in two Bali Province districts. At baseline, data regarding sociodemographic characteristics, knowledge levels, and attitudes toward antibiotic use were collected. MPC effectiveness was assessed using Morisky medication adherence scale-8. Of 300 recruited patients, 290 participated (response rate, 96.67%). The baseline study revealed that knowledge regarding short-term antibiotic use is lacking; however, awareness regarding antimicrobial resistance is high. MPC significantly improved short-term antibiotic compliance (risk ratio, 2.849; 95% confidence interval, 1.904-6.640; p<0.001). The mean rank significantly differed between the intervention (61.05) and control groups (37.95). The proportions of compliant patients in the intervention and control groups were 35.6% and 12.5%, respectively. The main reason for low compliance was forgetting and not being made aware by pharmacy workers in the intervention (46.8%) and control (55.6%) groups, respectively. These findings provide insights for improving pharmaceutical care.
Co-Authors Dyah Pradnyaparmita Duarsa Felia Rizka Sudrajat I Gusti Ayu Rai Widowati Ni Nyoman Sri Budayanti Pande Putu Januraga