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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Biomedika Jurnal Respirologi Indonesia MAHESA : Malahayati Health Student Journal
Dewi Anggraini
KJF Mikrobiologi Fakultas Kedokteran Universitas Riau
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Cotrimoxasole-Resistant Stenotropomonas maltophilia Infection : Case Report Dani Rosdiana; Dewi Anggraini
Jurnal Ilmu Kedokteran Vol 12, No 1 (2018): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.709 KB) | DOI: 10.26891/JIK.v12i1.2018.57-61

Abstract

Stenotrophomonas maltophilia is an important multidrug-resistant nosocomial pathogen associated with high mortality. This infection did not elucide clearly in Riau. We reported two Cotrimoxaxole Resistant Stenotrophomonas maltophilia in patient of Arifin Achmad Hospital which refered from peripheral hospital in another region. They had similar clinical appereance such as long stay hospitalization, bad clinical appearance and had a history of meropenem exposure before. We performed urin culture to make appropriate diagnostic and treatment also. Stenotrophomonas maltophilia bacteria was found in urine isolate. The sensitivity test showed that this bacteria had Cotrimoxasole resistant that standard antibiotic of this bacteria. The management of these cases become complicated due to decrease of renal function in one patient. We had to make dose adjustment of parenteral levofloxacin, giving good nutrition,  counted fluid balance and repaired others clinical conditions.Beside of its high mortality and morbidity, the outcomes of both these patients were good.
Pola Sensitivitas Isolat Klinis Bakteri Gram Negatif Multiresisten Obat Terhadap Fosfomisin dari Beberapa Rumah Sakit Kota Pekanbaru Dewi Anggraini; Atya Nasmah; Fauzia Andrini
Jurnal Ilmu Kedokteran Vol 13, No 1 (2019): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.232 KB) | DOI: 10.26891/JIK.v13i1.2019.28-35

Abstract

Over the last few years, there has been a decrease in amount of effective antibiotics, coincide with the lack of new antibiotics relevant for the treatment of Gram negative multi-drug resistant organisms infections. This problem can be overcome by the assessment and re-introduction of old antibiotics such as fosfomycin. Fosfomycin is a broad spectrum antibiotic that is bactericidal. This study aimed to find out the sensitivity pattern of clinical isolate multi-drug resistant Gram negative bacteria to fosfomycin with descriptive cross sectional method. The sample used in this study was clinical isolates collection of Microbiology Laboratory Faculty of Medicine, University of Riau from Hospitals in Pekanbaru. The result showedsensitivity to fosfomycin Escherichia coli producing ESBL (88%), Klebsiella pneumoniae producing ESBL (95%), Acinotobacter baumannii resistant meropenem (27%), Pseudomonas aeruginosa resistant meropenem (36%) and K.pneumoniae resistant meropenem (70%). Fosfomycin can be used as alternative therapy for infections caused by Gram-negative Multi-drug resistant organisms.
POLA BAKTERI DAN ANTIBIOGRAM PENYEBAB ULKUS DIABETIKUM DI RSUD ARIFIN ACHMAD PROVINSI RIAU PERIODE 2015 – 2018 Dewi Anggraini; Indra Yovi; Riza Yefri; Erwin Christianto; Eka Zulya Syahputri
Biomedika Vol 12, No 1 (2020): Biomedika Februari 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i1.9316

Abstract

ABSTRAKUlkus diabetikum adalah salah satu komplikasi dari diabetes mellitus. Ulkus ini terjadi akibat kerusakan  sistem saraf dan pembuluh darah akibat dari hiperglikemia yang tidak terkontrol. Kurangnya nutrisi dari pembuluh darah serta penurunan sensasi akibat kerusakan jaringan saraf memudahkan terjadinya ulserasi infeksi. Pola bakteri ulkus diabetikum dan resistensi antibiotik perlu diketahui untuk meningkatkan kesembuhan bagi pasien. Penelitian ini dilakukan di RS X Riau periode tahun 2015-2018. Data penelitian didapatkan dari Laboratorium Mikrobiologi RS X Riau. Hasil penelitian menunjukkan bahwa Klebsiella pneumonia adalah bakteri yang paling banyak menginfeksi penderita ulkus diabetikum di Rumah Sakit ini yaitu sebesar 17,9%. Bakteri lain yang menjadi penyebab adalah Escherichia coli (16,5%), Staphylococcus aureus (16,5%), Acinetobacter baumanii (14,7%) dan Pseudomonas aeruginosa (8,7%). Uji sensitivitas antibiotik menunjukkan bahwa Klebsiella pneumonia dan Escherichia coli paling sensitif terhadap antibiotik ertapenem, meropenem, amikacin dan tigecycline. Staphylococcus aureus ditemukan sangat resisten terhadap cefoxitine. Acinetobacter baumanii sensitif terhadap amikacin dan tigecycline, sedangkan Pseudomonas aeruginosa 100% resisten terhadap ampicillin, sefazolin, seftriakson, tygecycline, dan kotrimoksazol.Kata Kunci: Ulkus Diabetikum, Pola Bakteri, Pola Resistensi, Sensitifitas, Antibiotik  ABSTRACTDiabetic ulcer is a condition of diabetes’s complication. These ulcers occur due to damage of nerve tissues and blood vessels caused by uncontrolled hyperglycemia. Lack of nutrition from blood vessels and decreased sensation due to nerve tissue damage facilitates ulceration of the infection. It is important to know how the pattern of bacteria and antibiotic’s resistance to improve disease’s prognosis. This research was conducted at X Hospital Riau in the 2015-2018 periods. The research data was obtained from the Microbiology Laboratory of X Hospital Riau. The results showed that Klebsiella pneumonia was the most infecting bacterium with diabetic ulcer patients at this hospital, which was 17.9%. Other bacteria that cause are Escherichia coli (16.5%), Staphylococcus aureus (16.5%), Acinetobacter baumanii (14.7%) and Pseudomonas aeruginosa (8.7%). Antibiotic sensitivity tests show that Klebsiella pneumonia and Escherichia coli are most sensitive to ertapenem, meropenem, amikacin and tigecycline antibiotics. Staphylococcus aureus was found to be very resistant to cefoxitine. Acinetobacter baumanii sensitive to amikacin and tigecycline and Pseudomonas aeruginosa 100% resistant to ampicillin, cefazolin, ceftriaxone, tygecycline, and cotrimoxazole.Keywords: Diabetic Ulcer, Bacterial Pattern, Resistance Pattern, Sensitivity, Antibiotics
GAMBARAN SKRINING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) PADA PASIEN ORTOPEDI DI RS X RIAU Dewi Anggraini; Muhammad Ihsan; Maya Savira; Fauzia Andrini Djojosugito; Farah Mardhiyah
Biomedika Vol 13, No 2 (2021): Biomedika Agustus 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i2.11875

Abstract

ABSTRAKMethicillin-resistant Staphylococcus aureus (MRSA) adalah strain Staphylococcus aureus yang resisten terhadap antibiotik golongan beta laktam. Pasien karier MRSA dinilai meningkatkan kejadian komplikasi paska operasi pada pasien ortopedi. Penelitian ini bertujuan untuk mengetahui gambaran dan prevalensi skrining MRSA pada pasien ortopedi di Bangsal Bedah RS X Riau.  Metode penelitian ini adalah deskriptif dengan rancangan cross-sectional menggunakan data primer dan sekunder responden.  Penelitian ini dilakukan pada 34 responden di Bangsal Bedah RS X Riau sejak Januari 2019 – Maret 2020.  Persentase responden yang memiliki faktor risiko sebagai karier MRSA yaitu: 5,9% dengan riwayat operasi 3 bulan terakhir; 2,9% dengan riwayat penggunaan antibiotik dalam 6 bulan terakhir, 29,4% dengan luka terbuka akut, 11,8% dengan riwayat rawat inap, 0% dengan riwayat kultur MRSA, dan 17,6% merupakan rujukan rumah sakit lain. Pada responden berisiko tersebut ditemukan kolonisasi Staphylococcus aureus pada 9 orang responden (26%) di bagian nasal anterior dan tidak ditemukan adanya bakteri MRSA (0%). Kesimpulan yang didapat dari penelitian ini adalah tidak ditemukannya bakteri MRSA pada seluruh sampel yang diperiksa. Kata Kunci: MRSA, Ortopedi, Skrining, Staphylococcus aureus..  ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) is a strain of Staphylococcus aureus that is resistant to beta-lactam antibiotics. Patients with MRSA carrier are considered to increase the incidence of post-operative complications in orthopedic patients. This study aimed to determine the prevalence and illustration of MRSA screening in orthopedic patients in X Hospital Riau. This research method was descriptive with cross-sectional design using primary and secondary data of respondents. This study was conducted on 34 respondents in surgical ward at X Hospital Riau from January 2019 to March 2020. The percentage of respondents who had risk factors as MRSA carriers were: 5.9% with a history of surgery in the last 3 months; 2.9% with a history of antibiotic use in the last 6 months, 29.4% with an acute open wound, 11.8% with a history of hospitalization, 0% with a history of MRSA culture, and 17.6% a referral to another hospital. Colonization of Staphylococcus aureus was found in 9 respondents (26%) in the anterior part of the nose and no MRSA bacteria were found (0%). The conclusion from this study is that MRSA bacteria were not found in all samples because only a few respondents had risk factors for becoming MRSA carrier. Keywords: MRSA, Orthopedic, Screening, Staphylococcus aureus.
Profil and Evaluation of Resistant Tuberculosis Drug’s Side Effect in Diabetes and Non Diabetes Mellitus Patient at RSUD Arifin Achmad Dani Rosdiana; Dewi Anggraini; Indra Yovi; Marlina Tasril
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.119

Abstract

Backgrounds: Diabetes mellitus (DM) increases the risk of reactivation of tuberculosis included multi-resistant drug tuberculosis (MDR-TB). This situation is threatening Riau province due to the high prevalence of DM. Since 2014 Arifin Achmad Hospital as a referral hospital of MDR-TB management. It’s treatment especially in DM patients, requires an evaluation of both outcome and side effects. This evaluation needs to be compared with non-DM MDR TB patients. The aim of this study was to evaluate and analyse patient’s characteristic, conversion of smear or culture, drugs side effect and treatment outcome. Methods: This is a cross sectional retrospective study in RSUD Arifin Achmad Pekanbaru on April-October 2018. Sample of this study were all patients from 2014 – 2017. This study was divided into 2 groups, namely the DM and non-DM groups, then analysed the differences between the two groups Results: There were 113 MDR TB patients had its treatment, which 61% of the patients were male. Baseline data show 26.5% of MDR TB patients have comorbid DM. The most common side effects were nausea and vomiting (100%) in all subjects. In the MDR TB DM group, we found included: well controlled plasma glucose level was 33.3%, severe side effects was16.7%, conversion in the second month 40% and cured or complete treatment was 30%. Conclusions: As many as 26,5% of MDR TB patients had DM comorbidity. There were no differences in the percentage of drugs side effects, smear conversion in the second month and treatment outcome between MDR TB DM and MDR TB non-DM group. (J Respir Indo. 2020; 40(3): 156-62)
Use of Antibiotics and Probiotic Lactobacilli in the Treatment of Preterm Premature Rupture of Membranes: a Review Fitra Afdanil; Donel Suhaimi; Dewi Anggraini
MAHESA : Malahayati Health Student Journal Vol 4, No 4 (2024): Volume 4 Nomor 4 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i4.14159

Abstract

ABSTRACT To review the current evidence of the potential use of antibiotics and probiotics Lactobacillus in preterm premature rupture of membranes cases and to see the effect on microorganism concentrations especially Streptococcus agalatiae and Lactobacillus. This review used several databases (Google Scholar, Pubmed, and Science Direct) and searched for English and Indonesian articles in the last ten years. Articles were received in the form of case reports, observational studies and clinical trials that discussed the use of antibiotics and probiotic Lactobacillus in premature rupture of membranes especially in preterm pregnancy. After searching the database and eliminating duplicates and articles unrelated to the topic, we included some articles in this review. Prophylactic antibiotics are also expected to prolong the latent phase, thereby reducing the risk of fetomaternal morbidity and mortality. Penicillin is often recommended in preterm PROM, because broad-spectrum antibiotics are better as infection prophylaxis. Providing alternative therapy with lactobacillus probiotics is believed to prevent preterm birth and has the benefit of being a safe and effective therapy in restoring normal vaginal microflora and preventing vaginal infections during pregnancy. However, further research is needed to see the effectiveness of lactobacillus probiotics and look at the concentration of microbes, especially Streptococcus agalctiae and Lactobacillus. Keywords: Preterm Premature Rupture of Membranes, Antibiotics, Probiotics  Lactobacillus, Streptococcus Agalactiae
Co-Authors Atya Nasmah Dani Rosdiana Donel Suhaimi Eka Zulya Syahputri Erwin Christianto Farah Mardhiyah Fauzia Andrini Fauzia Andrini Djojosugito Fitra Afdanil Indra Yovi Indra Yovi Marlina Tasril Maya Savira Muhammad Ihsan Riza Yefri