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Alida Harahap
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Medicine & Pharmacology

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Prognostic factors of neuroinflammation and oxidative stress in brain injury patients at Cipto Mangunkusumo Hospital Jakarta Aman, Renindra A.; Ichwan, Syaiful; Harahap, Alida; Wibisono, Yusuf; Yuliatri, Nia; Aulia, Mohammad A.; Freisleben, Hans-Joachim
Medical Journal of Indonesia Vol 21, No 3 (2012): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.22 KB) | DOI: 10.13181/mji.v21i3.499

Abstract

Background: This study aims to determine the association between neuroinflammation and oxidative stress with prognosis of brain injury patients and the association between neurosurgical procedure with neuroinflammation and oxidative stress condititons.Methods: The study design is a prospective observation of 40 brain injury patients who underwent surgery. IL-6, uric acid, MDA, NR2A antibodies and GSH serum level of pre- and 1 day post-operation on brain injury patients were measured, and their association with GCS, GOS and neurosurgical procedures were analyzed.Results: The post-operative IL-6 serum level showed a downward trend compared to pre-operative value (mean decrease: -190.61 pg/mL). The post-operative IL-6 level was significantly associated with GCS 7 days post-operation (p = 0.006), with OR 24. The post-operative IL-6 serum level was significantly associated with GOS 3 months post-trauma (p = 0.016) with OR 11.6. The post-operative uric acid serum level showed a downward trend compared to pre-operative value (mean decrease: -0.26 mg/dL). There was a significant difference between the mean value of post-operative uric acid serum level in patients with 7 days post-trauma with GCS ≤ 8 (mean: 4.16 mg/dL) and GCS > 8 (mean: 2.71 mg/dL), (p = 0.042). The post-operative MDA serum level showed a downward trend compared to pre-operative value (mean decrease: -0.08 nmol/mL). There is no significant association between MDA serum level, GCS and GOS and no significant association of NR2A antibody and GSH serum level with GCS, GOS and neurosurgical procedure. From the multivariate analysis, the most important neuroinflammatory variable associated with GCS and GOS is IL-6.Conclusion: Neuroinflammation and oxidative stress may have prognostic values in brain-injured patients, in particular IL-6. Neurosurgical procedures may decrease the neuroinflammation process (Med J Indones. 2012;21:152-9)Keywords: Neuroinflammation, oxidative stress, traumatic brain injury, neurosurgical procedures, interleukin 6, uric acid, malondialdehyde, NR2A antibody, glutathione
Demographic characteristics, risk factors and immunocytochemistry of p16INK4a, Ki-67, MCM5, and survivin as predictors for the progress of cervical precancer lesion Indarti, Junita; Aziz, Mohammad F.; Sutrisna, Bambang; Siregar, Nuryati C.; Suryawati, Bethy; Harahap, Alida
Medical Journal of Indonesia Vol 19, No 3 (2010): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.035 KB) | DOI: 10.13181/mji.v19i3.398

Abstract

Aim To identify the predictive factors and biomarkers in the progression of cervical precancer lesion or Cervical Intraepithelial Neoplasia (CIN).Methods The study was conducted from August 2007 to September 2008. Design of the study was case-control with stratifications of test dose response. The cases were patients with CIN. Control patients were non CIN patients. Bivariate analysis followed by multivariate analysis was conducted.Results There were 130 patients, consisting of 124 CIN patients divided into CIN 1, CIN 2 and CIN 3, with the following numbers of patients: 30, 41, and 33, respectively and 26 patients without CIN (non CIN). Bivariate analysis showed that age < 41 years, education ≥ 13 years, sexual partner ≥ 2, first sexual relationship at age < 22 years, smoking, the presence of sexuallly transmitted infections, positive HPV DNA, high p16INK4a, Ki-67, MCM5 and Survivin expression constituted independent variables for the occurrence of CIN with P value of < 0.05. However, on multivariate analysis, independent variables that emerged were age, education ≥ 13 years, sexual partner ≥ 2 persons, positive HPV DNA, and over expression of p16INK4a, Ki-67 and Survivin that showed a P value of < 0.005.Conclusion Younger ages, education age ≥ 13 years, sexual partner ≥ 2 persons, positive HPV DNA, high p16INK4a, Ki-67 and Survivin expression constituted the risk factors for the occurrence of the progress of CIN, and was used in the equation to predict the progress of cervical precancer lesion. (Med J Indones 2010;19:147-53)Key words: case control study, equation, HPV DNA
Co-Authors A.A. Ketut Agung Cahyawan W Abdulmuthalib Abdulmuthalib Asmarinah Asmarinah Bambang Sutrisna Bethy Suryawati Cosphiadi Irawan Djumhana Atmakusumah, Djumhana Fatimah Eliana, Fatimah HANS-JOACHIM FREISLEBEN Joedo Prihartono Junita Indarti Lim Weng Kong, Lim Weng Mohammad A. Aulia Mohammad F. Aziz Muchtaruddin Mansyur Nia Yuliatri Nurjati Chaeranie Siregar, Nurjati Chaeranie Nuryati C. Siregar Ong Choon Kiat, Ong Choon Pradana Suwondo Renindra A. Aman Samsuridjal Djauzi Syaiful Ichwan The Bin Tean, The Bin Tjokorda Gde Dalem Pemayun