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Endang Sri Hardjanti
Faculty of Medicine, Sebelas Maret University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Hubungan antara Tingkat Pendidikan dengan Pengetahuan Dan Sikap Ibu Tentang Pemberian Imunisasi BCG Pada Bayi Usia 0-2 Bulan di Wilayah Kerja Puskesmas Kebakkramat I Karanganyar Wijaya, Dedy Tri; Hardjanti, Endang Sri; Hartanto, Rifai
Nexus Kedokteran Komunitas Vol 2, No 2 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Mothers role is very important in BCG immunization to their babies, because immunization is useful to prevent and break the chain of TB disease. This research aims to prove that the degree of education has a strong correlation with the knowledge and attitude of mothers in BCG immunization. Methods: This study was observational analytic conduct by cross-sectional approach. The study was conducted in July-September 20 012 health centers in the working area Kebakkramat I, Karanganyar. Sample of 45 mothers were selected by purposive quota sampling. The variables studied include degree of educational as independent variables, the knowledge and attitudes of mothers about BCG immunization as the dependent variables. This research tool used questionnaires to measure all these variables and have done test validity and reliability. Data were analyzed using kolmogorov-Smirnov models using SPSS 17 for windows. Results: This study shows that the degree of education has a significant association with increased knowledge (kolmogorov-Smirnov Z= 1,375 ; p=0,046) but did not have a significant association with maternal attitudes about BCG immunization (Kolmogorov-Smirnov Z = 1.167, p = 0.131). Conclusion: There is a significant correlation between the degree of education with knowledge of BCG immunization and there is no significant relationship between the level of maternal education and attitudes about BCG immunization. Keywords: Degree of education, Knowledge, Attitute, BCG immunization
Pengaruh Ekstrak Kulit Manggis dalam Mencegah Peningkatan Kadar Blood Urea Nitrogen pada Tikus Putih (Rattus norvegicus) Galur Wistar yang Diinduksi Gentamisin Winiasih, Putri Ayu; Hardjanti, Endang Sri; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Gentamicin, which is often used for infection treatment against aerobic Gram negative bacteria, is known having nephrotoxic effects through the inflammation mechanisms. Mangosteen pericarp has antioxidant activity and antiinflammation properties which attenuates oxidative stress, inflammatory and fibrotic pathways, hence it potentially prevents renal damages. Gentamicin-induced renal damages can be measured from elevation of blood urea nitrogen (BUN) levels. The aim of this study was to evaluate the effect of mangosteen pericarp extract on BUN levels in Wistar rats induced by gentamicin. Methods: This was an experimental study with pre- and posttest controlled group design. Thirty white male Wistar rats aged 8-12 weeks and weighed 135-170 grams were randomly divided into three groups. Normal control group (P1) was administered  orally with Natrium Carboxymethylcellulose (Na CMC) 0.5%. Negative control group (P2) got intraperitoneal (i.p.) injection of gentamicin at total dose of 100 mg/kgBW. Treatment group (P3) was induced by gentamicin and 125 mg/kgBW mangosteen pericarp extract. The extract was administered orally thirty minutes after gentamicin injection for ten consecutive days. Blood samples were collected from retroorbital veins and BUN levels were measured at day 0 and day 11. Data were analyzed statistically by one-way ANOVA followed by Tukey’s multiple comparison tests (α=0.05). Results: One-way ANOVA test showed no significant difference in pretest BUN levels among three groups (p=0.902). At day 11, BUN level in P2 group was significantly higher than those in P1 and P3 groups. Tukey’s multiple comparison test further showed significant difference between P1-P2 and P2-P3 (p<0.001). No significant difference of BUN level was found between P1-P3 (p=0.386). Conclusions: Mangosteen pericarp extract could significantly prevent the elevation of BUN levels in Wistar rats induced by gentamicin. Keywords: mangosteen pericarp extract, gentamicin, BUN 
Pengaruh Pemberian Ekstrak Kulit Manggis (Garcinia mangostana, Linn.) dalam Mencegah Peningkatan Kadar Kreatinin Darah pada Tikus (Rattus norvegicus) yang Diinduksi Gentamisin Prakoso, Surya Adhi; Hardjanti, Endang Sri; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Gentamicin may cause nephrotoxicity and inhibits blood creatinine excretion. Xanthone from mangosteen pericarp has antioxidant and antiinflammation effects and can potentially protect kidney from inflammatory-mediated gentamicin’s nephrotoxicity. Gentamicin-induced renal damage can be identified from the elevation of blood creatinine levels. The purpose of this research was to find the potential of mangosteen pericarp extract to prevent the elevation of blood creatinine levels. Methods: This was an experimental research with pre and posttest controlled group design. Samples were 30 male Wistar-strain rats, 2-3 months old with approximately 200 gram of weight. Samples were randomly divided into 3 groups:control group (KN) administered Na CMC 0.5% orally, negative control group (K-) administered gentamicin 100 mg/kgBW intraperitoneally, and treatment group (KD) administered gentamicin 100 mg/kgBW intraperitoneally and 125 mg/kgBW mangosteen pericarp extract orally. Blood creatinine levels were assessed before treatment and 10 days after treatment by spectrophotometer. Data collected were analysed by Kruskal-Wallis and Mann-Whitney tests. Results: There was significant difference of blood creatinine levels before and after treatment among the three groups (p<0.001). Mann-Whitney tests showed statistically significant differences of creatinine level between KN-K- and KD-K- (p<0.001). No significant difference of blood creatinine levels was found for KN-KD comparison(p=0.06). Conclusion: Mangosteen pericarp extract at dose of 125 mg/kgBW prevented the elevation of blood creatinine levels in Wistar rats induced by gentamicin. Keywords: mangosteen pericarp extract, gentamicin, blood creatinine level  
Co-Authors Dedy Tri Wijaya Nur Hafidha Hikmayani Putri Ayu Winiasih Rifai Hartanto Surya Adhi Prakoso