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All Journal Medical Journal of Indonesia Paediatrica Indonesiana
Daldiyono Harjodisastro
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Effects of realimentation on small intestinal morphology and disaccharidase activity in malnutrition Sprague-Dawley rats Sosrosumihardjo, Rustadi; Firmansyah, Agus; Rasad, Asri; Harjodisastro, Daldiyono; Ridwan, Endi; Wanandi, Septilia I.; Retno, Dwirini
Medical Journal of Indonesia Vol 15, No 4 (2006): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.582 KB) | DOI: 10.13181/mji.v15i4.238

Abstract

Low birth-weight infant and intrauterine growth retardation are still a health problem, especially in Indonesia due to high prevalence and need to be reduced. Malnutrition in infants are most common occur in low birth-weight infants. Malnutrition in rats resulted in hypotrophic and normoplastic mucosa of the small intestine. The finding was not only showed that small intestine was able to maintain its cell number in condition with restriction nutrient, however also suggested the posibility of epithelial regeneration if given adequate nutrient intake. Did realimentation recover the hypotrophic normoplastic mucosa to normotrophic normoplastic? The study aim to answer that question. Experimental animal study with post test-control group design was performed using 40 male litter of Sprague-Dawley rats, was fed standard chow. The study was divided into phases prenatally-induced malnutrition and continued with phase realimentation. The result of this study is the body weight, mucosal thickness, villus height, cryptus depth, ratio of villus/ crypt, number of villi, protein content, and disaccharidases of rats realimentation group was higher than non-realimentation group, but lower than control group. Prenatally-induced malnutrition did not reduced the population of small intestinal enterocytes. Realimentation in rats in prenatally-induced malnutrition was able to improve the hypotrophy of small intestinal mucosa and to increase the disaccharidases activities but did not reach the normal values. Realimentation in rats in prenatally-induced malnutrition was able to improve the maturity of small intestine mucosa but did not reach the normal values. The information will be helpfull to decide the policy of maternal malnutrition. (Med J Indones 2006; 15:208-16)Keywords: small intestinal morphology, disaccharidase activity, Sprague-Dawley rats, prenatally-induced malnutrition, realimentation.
Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation Rustadi Sosrosumihardjo; Agus Firmansyah; Asri Rasad; Daldiyono Harjodisastro; Endi Ridwan; Septilia Inawati Wanandi; Dwirini Retno
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.995 KB) | DOI: 10.14238/pi46.5.2006.229-35

Abstract

Background The most common cause of failure to thrive in in-fants is malnutrition which causes histological and biochemicalchanges of small intestine. Studies on histology and enzyme ac-tivity of small intestinal mucosa were not much developed.Objective To study about histology and disaccharidases activity ofsmall intestinal mucosa in post-weaning-induced malnourished rats.Methods We used Sprague-Dawley white rats as the subjects ofthis study with post test-control group design. The study was per-formed at the CentER for Research of Food and Nutrition Devel-opment from April 2003 to December 2004.Results There were a decrease of body weight (hypotrophy nor-moblastic) and an increase of disaccharidase activity of small in-testinal mucosa in post-weaning-induced malnourished rats. Afterrealimentation, there were an increase of body weight, an improve-ment of the hypotrophy, and a decrease of the enzyme but theystill cannot reach normal condition.Conclusion In malnourished rats, there are decrease of bodyweight hypotrophy normoblastic and increase of disaccharidasesactivity of intestinal mucosa that are improved after realimentation
Co-Authors Agus Firmansyah Agus Firmansyah Asri Rasad Asri Rasad Dwirini Retno Gunarti Endi Ridwan Endi Ridwan Rustadi Sosrosumihardjo Rustadi Sosrosumihardjo Septilia I. Wanandi Septilia Inawati Wanandi