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. Rajuddin
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Ovarian cryopreservation and transplantation: A preserving fertility procedure Bram Pradipta; . Rajuddin; Mohd Andalas
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

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Abstract

Cancer is a major health problem in both developed and developing countries. In women, cancer incidence rates increased every year. Developments in treatment modalities and the ability to detect tumours in the early stages increased their survival rate but also raise fertility problems. Those problems are the fertility preservation for patient who have to endure gonadotoxic chemotherapy and or radiation even though they still need their fertility functions. Ovarian cryopreservation and autotransplantation were initially designed to protect and restore reproductive function in patients receiving sterilizing chemotherapy and/or radiotherapy. Other indications including patients undergoing haematopietic stem cell transplantation, autoimmune diseases and those undergoing oophorectomy for non-cancer conditions. Options in cryopreserved ovarian tissues include autotransplantation and xenotransplantation. An orthotopic site or a heterotopic site can be considered for autotransplantation. Xenotransplantation of human ovarian tissue into immunodeficient animals can prevent immunological rejection.  The theoretical advantage of orthotopic grafts is the restoration of normal reproductive function and natural conception after transplantation but application for cancer patients is problematic because of the potential risk of transmission of microscopic metastatic disease. With Xenotransplantantion, the possibility of cancer transmission and relapse can be eliminated because cancer cells cannot penetrate the zona pellucida, and some technical difficulties of in vitro growth and maturation of primordial follicles can be bypassed. But it is still unknown whether conditions for the growth and maturation of human oocytes in an animal host are comparable to those in situ and whether animal pathogens can be transmitted to human tissue with it. Ovarian tissue cryopreservation is the fertility preservation option for prepubertal girls and for women who face thehigh likelihood of diminished ovarian reserve requiring immediate treatment. Its procedure are still within improvement and also in the study of understanding its mechanism. In the future, studies and large clinical trials are still needed to develop better cryoprotectants and cryopreservation protocols and also standardization - optimization transplantation techniques
Diabetes mellitus in pregnancy and obstetrics outcome Eva Febia; . Rajuddin
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 2, No 1 (2012): Life Sciences
Publisher : Syiah Kuala University

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Diabetes mellitus in pregnancy was associated with maternal and neonatal mortality and morbidity. This paper was purposed to assess the several cases of diabetes mellitus in pregnancy that were managed in Zainoel Abidin Hospital, Banda Aceh. There were ten cases of diabetes mellitus in pregnancy in Obstetrics Department Zainoel Abidin Hospital, Banda Aceh. Obstetrics outcomes were noted which include cesarean section, fetal distress, macrosomia, intra uterine fetal death, neonatal hypoglycemia, and neonatal death. We also explained patophysiology of diabetes mellitus in pregnancy, delivery, obstetrics complications, and neonatal complications. It was concluded that diabetes mellitus in pregnancy was associated with increased rate of obstetrics and neonatal mortality and morbidity
Spontaneous initiation of parturition after two-days-course of lung maturation and controversies in management of pre-eclampsia: A case report Eva Febia; . Rajuddin
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

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There have been many controversies on how we should treat patients with  preeclampsia, how and when we should deliver the baby. This case report is purposed to evaluate one case of spontaneous parturition which ended up with vaginal delivery in one patient with preterm severe preeclampsia. We evaluate the best management which result in the best outcome for the patient and her baby. This is the case of Mrs N, 34 years old in 33-34 weeks gestational age with severe preeclampsia. When she came the blood pressure was 190/120 mmHg, protein urine +3. The blood pressure was controlled with nifedipine. The patient was given magnesium sulphate, N-acetyl cystein, and vitamin C as antioxidants. We were succeeded in completing two days of lung maturation with dexamethasone in order to give the best outcome for the baby. However, at the end, after two days of lung maturation, the patient started to enter the active phase of parturition spontaneously without labor of induction. We hypothesized that the high level of corticosteroid stimulated by the fetus initiated the process of labor. Patient delivered baby boy, 1300 grams, Apgar Score 7/8 that breathed spontaneously in room air. The patient’s condition was improving after parturition. Nifedipine, magnesium sulphate was considered the best management in pre-eclampsia.  Short course of lung maturation with dexamethasone was also considered to be beneficial for the baby. However, the initiation of parturition and the use of antioxidant as well as n-acetyl cystein in this patients was under debatable discussion.
Co-Authors Bram Pradipta Eva Febia Eva Febia Mohd Andalas