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All Journal Nexus Kedokteran Komunitas Nexus Biomedika Nexus Kedokteran Translasional MIX : Jurnal Ilmiah Manajemen
MUTHMAINAH .
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Medicine & Pharmacology Social Sciences

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Asosiasi Pengetahuan Mengenai Rokok dengan Sikap dan Perilaku Merokok pada Remaja ROCHIMA RIDHA HIDAYAH; ARI NATALIA PROBANDARI; MUTHMAINAH .
Nexus Kedokteran Komunitas Vol 1, No 2 (2012): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: The level of knowledge on smoking may influences the attitudes and behavior of smoking. A previous research found that, smoking behavior began in the early years of teenage (11-15 years old). This study aimed to determine the association between the level of knowledge about the dangers of smoking cigarettes and attitudes toward smoking and smoking behavior in early adolescence. Methods: The study design was an observational analytic cross-sectional study which was conducted during March 2012 among 98 students of SMP Negeri 01 Colomadu, Karanganyar. Sampling technique in this study was multi-stage cluster sampling. We used a questionnaire to measure current knowledge on smoking and the dangers of smoking, attitudes, and smoking behavior, which had been tested validity and reliability. Data analysis used the Fisher Exact Test and Chi-Square Test. Results: This study found no statistical significant relationship between the level of knowledge of the attitudes toward smoking (p = 0,509; OR = 1,86; Cl95% = 0,45-7,66). The level of knowledge increased the risk of smoking behavior in the past by 0,7 times (p = 0,366; OR = 1,50; Cl95% = 0,62-3,62), but not statistical significantly. There were no statistical significant relationship between the level of knowledge of the behavior of current smoking (p = 0,311; OR = 4,23; Cl95% = 0,42-42,20) and past smoking (p = 0,366; OR = 1,50; Cl95% = 0,62-3,62). Conclusions: The knowledge has no statistical significant association with adolescent attitudes toward smoking and smoking behavior of adolescents. Further research with stronger study designs are needed to study the association between knowledge, attitude on smoking and smoking behavior among early teenagers. Keywords: Level of knowledge challenged cigarettes, attitudes, smoking behavior.
The Protection Effect of Mango (Mangifera indica L.) Fruit Juice on Renal Histological Structure of Mice Induced Paracetamol Wahyu Wirawan; Muthmainah .; Ruben Dharmawan
Nexus Kedokteran Translasional Vol 2, No 2 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Mangifera indica L. fruit contains vitamin C, vitamin E and ?-carotene which are thought to protect the ren from free radicals. In present study, Mangifera indica L. fruit is evaluated for its protection effect on paracetamol induced renal cell damage in mice. Methods: To evaluate the nefroprotective effect of Mangifera indica L. fruit juice, 28 male Swiss webster mice were equally divided into four groups. Mice in group I (KKn) were given aquadest and group II (KKp) received paracetamol for 3 days. Group III-IV (KP1 and KP2) not only received paracetamol, but also received multilevel doses of Mangifera indica L. fruit juice for 14 days. Mice were sacrificed on the 15th day and histological preparation was made to evaluate histological damage in ren. Renal histological structures were assessed by counting the number of renal cells on proximal tubule undergoing pyknosis, karyorhexis, and karyolysis. Data were analyzed using the One Way ANOVA test (? = 0.05) and the Post Hoc Multiple Comparisons (LSD) test (? = 0.05). Results: The mean renal cell histological damage score in KKp group : 36.43 1.66, KKn group : 6.5 1.34, KP1 group : 14.86 1.56, KP2 group : 8.5 2.13. The results of One Way ANOVA test showed significant difference between the four groups (p=0.000) and the results of LSD test showed significant differences between each other group (p<0.005). Conclusions: Mango fruit juice can decrease the damage of renal histological structure in mice induced by paracetamol, and increasing the dose of mango fruit juice can increase its protection effect on histological structure of renal cell therefore it cant give the same histological structure as in control group. Keywords: Mangifera indica L. fruit juice, paracetamol, renal cell histological damage.
Effects of Green Beans (Phaseolus vulgaris L.) Extracts on Triglyceride Levels of Wistar Rats with Hyperlipidemia Khairunnisa Nurul Huda; Andri Putranto; Muthmainah .
Nexus Kedokteran Translasional Vol 5, No 1 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Dyslipidemia is characterized by increase of triglyceride. This lipid disorder associates with obesity, stroke and heart diseases. A recent study has been reported that the use of triglyceride-lowering drugs have many side effects. Therefore, some patients of dyslipidemia prefer to use complementer medicine like herbal medicine rather than the existing drugs. Green bean contains some secondary metabolites, which have hypolipidemic effects. This present study aimed to investigate the effect of green bean (Phaseolus vulgaris L.) extract on triglyceride levels of rats with hyperlipidemia. Methods: This study was a laboratory experimental study with post test only control group design. Male Wistar rats, which aged 3 months old, and weighted 200 g were use in this study. Thirty rats were divided into five groups : two control groups (KKn, KKi) and 3 treatment groups. KKn was given distilled water and KKi was given 4.5 mL duck egg yolks orally and propylthiouracil (PTU) 0.01% ad libitum for 28 days. The treatment groups were given the same diet as the KKi group for 28 days. Green bean extract (GBE) (50, 100, and 150 mg/200g; per oral) was added in three treatment groups by the fifteen days of the experiment. The following day, rats were sacrificed and blood was collected from rats plexus retro-orbital. The serum triglyceride levels were determined using spectrophotometer. All collected data were analyzed by using One Way ANOVA test followed by Post Hoc test (? = 0.05). Result: Triglyceride levels of rats treated with green bean extracts (KP1, KP2, KP3) were lower than the control groups (KKn, KKi). The difference of triglyceride level reached significantly p = 0.000. The first treatment (KP1) group has 46.83 20.62 mg/dL triglyceride level, which was higher than other treatment group (KP2, KP3) (30 9.65 and 40.17 11.37 mg/dL). However, it was not statistical difference. Conclusions: Green Bean (Phaseolus vulgaris L.) extract 50-150 mg/bodyweight can reduce triglyceride levels of Wistar rats with hyperlipidemia. Further investigation will be required for determination of the effective dose reducing triglyceride level in the animal model. Keywords: green bean, triglyceride, hyperlipidemia, Rattus norvegicus
DETERMINANTS OF CUSTOMER`S SWITCHING INTENTION BASED ON EXPERIENCE AND SHARIA VALUE CONGRUITY Muthmainah .; Muhammad Cholil
MIX: JURNAL ILMIAH MANAJEMEN Vol 9, No 1 (2019): MIX: Jurnal Ilmiah Manajemen
Publisher : Universitas Mercu Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.843 KB) | DOI: 10.22441/mix.2019.v9i1.007

Abstract

This study aims to examine the factors that influence the customer`s switching  intention, which are influenced by customer satisfaction and customer loyalty based on customer experience and congruity  of sharia  values. The sample size of 195 Sharia banks customers in Surakarta was taken using convenient sampling method. The research analysis used hierarchical regression with customer satisfaction as the independent variable, customer`s switching  intention as the dependent variable and customer loyalty as a mediator variable. Besides that, it also uses customer experience and congrueity  to sharia values as a moderator variable.Validity test, reliability test and classic assumption test have been carried out and the results meet the criteria according to the specified standards. The results of the research analysis show that customer satisfaction has a positive and significant effect on customer loyalty and has a negative effect on the customer`s switching  intention and customer loyalty has a negative effect on customer`s switching intention. Customer loyalty partially mediates the effect of customer satisfaction on customer`s switching intention. However, the customer experience and congrueity sharia value  does not strengthen or weaken the influence of customer satisfaction on customer loyalty and on customer`s switching intention and does not strengthen or weaken the influence of customer loyalty on customer`s switching intention. The theoretical and practical implications of the results of research that are considered relevant and need to be discussed can be used as orientation and direction for future research
The Protection Effect of Centella asiatica L.Urban extract on the Kidney Histological Structure of Mice (Mus musculus ) induced by toxic doses of paracetamol Berlian Permata Sakti; Muthmainah .; Ratih Puspita Febrinasari
Nexus Biomedika Vol 4, No 1 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Centella asiatica L.Urban contains antioxidant compounds such as triterpenoid, essential oil and flavonoid. The compounds have significant activities to reduce oxidative stress that can make damage of kidney cells. This study aimed to investigate protection effect of Centella asiatica L.Urban extract on the kidney histological structure of mice (Mus musculus ) induced by toxic doses of paracetamol. Method: This study was an experimental laboratory research. Samples were 30 mice, Swiss webster type, 2-3 weeks old and 20 grams of weight. Samples were divided into 5 groups, each group consisted of 6 mice (Mus musculus). The control group (KK) was given no treatment, just regular feed. Induction group (KI) was induced by paracetamol but did not get any treatment, just got distilled water. KP1, KP2, and KP3 groups induced by paracetamol got treatment with Centella asiatica L.Urban extract at a dose of 5 mg, 10 mg and 20 mg per 20 gram of body weight. Kidney histological damage were assessed by the sum of the cell nucleus pyknosis, karyorrhexis, and karyolysis. Data were analyzed using one-way ANOVA and post hoc multiple comparison test. Result: The ANOVA test for all groups showed that p value was 0.000 (p < 0.05). The post hoc multiple comparisons test showed the significant differences between group KK-KI, KK-KP1, KK-KP2, KK-KP3, KI-KP1, KI-KP2, KI-KP3, KP1-KP2, KP1-KP3, and KP2-KP3. Conclusion: Centella asiatica L.Urban extract has a protection effect to kidney histological structure of mice (Mus musculus) induced by paracetamol. Keyword : Centella asiatica L.Urban, paracetamol, kidney damage.
Co-Authors Andri Putranto Ari Natalia Probandari Berlian Permata Sakti Khairunnisa Nurul Huda Muhammad Cholil Ratih Puspita Febrinasari ROCHIMA RIDHA HIDAYAH Ruben Dharmawan Wahyu Wirawan