Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Nexus Kedokteran Translasional Jurnal Media Gizi Indonesia (MGI)
Dono Indarto
Sebelas Maret University
Health Professions Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Exposure of hazardous compounds in Furniture Painting Induces Oxidative Stress through Increasing Plasma Malondialdehyde (MDA) Levels Ratna Oktaviani; Sinu Andhi Jusup; Dono Indarto
Nexus Kedokteran Translasional Vol 4, No 1 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.207 KB)

Abstract

Background: Some heavy metals and organic solvents like toluene and formaldehydeare hazardous chemicals that are usually used to paint furniture.These compounds may increase oxidative stress andassociatewithseveraldiseases.Oxidative stress is characterized by high levels of free radicals, which induce macromolecule oxidation including lipid. Lipid is oxidized to become reactive and toxic compounds like ethane and MDA. This study aimed to investigatethedifferences ofplasma MDA levels between furniture painters and non-painters. Method:This study was analytical observationwithcross sectional research design. Thisstudywas conducted in several furniture industries in Taunan, Jepara. 14 people who work as furniture painters were classified as the painter group and 14 people who work as non-furniture painters become the control group. The plasma MDA levels were measured by using Thiobarbituric Acid ReactiveSubstances(TBARS) test. The collected data was statistically analyzed by using student t and multiple linear regression tests. Result:The majority of people in painter group aged between 20-34 years old and was younger than that of control group (25-39 years old). A significant increase in MDA levels was observed in the painter group, compared with MDA levels of the control group (5.74 0.39 vs. 1.94 0.33 mol/L) with p value <0.001. Paint exposure was significantly associated with plasma MDA levels (r = 0,968; = 96,80%; p<0,001).Other factors such as nutritional status, food, psychic, sports and air pollutants had small proportion (3.20%) to increase the MDA levels. Conclusion:Plasma MDA levels of furniture painters increased approximately three-fold and are positively related to paint chemical exposure. This data suggests the possibility of oxidative stressin furniture painters although its pathogenesis needs further investigation. Keywords: Furniture painters,oxidativestress, plasma MDA level
Identification of Herbal Compounds as Thymidylate Synthase Inhibitors that more Potent than 5-Fluorouracil using Molecular Docking Yoga Mulia Pratama; Dono Indarto; Yuliana Heri Suselo
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.827 KB)

Abstract

Background: Development of new selective anticancer drug is an important necessary. Because of that, some effective way to screen herbal compounds which have good potency for developing drug is needed, one of them is using molecular docking methods. In this study, researchers identify herbal compounds as new thymidylate synthase (TS) inhibitors which more potent than 5-Fluorouracil (5-FU) using molecular docking. Methods: Three-dimensional structure samples of herbal compounds from Indonesian herbal database (herbaldb.ui.ac.id) were docked with three-dimensional structure of TS protein using iGEMDOCK program. Then, the compounds which have lower docking score than fdUMP, as standard ligand, clustered using ChemMine. Results: The docking result showed that 27 herbal compounds have docking score lower than fdUMP in iGEMDOCK program. The 27 compounds have higher affinity to fdUMP and it can form a stable complex with TS protein. Protein-ligand complexes showed that all of 27 compounds have same binding site with fdUMP. But folic acid is excluded from the result because it is a TS ligand. fdUMP has similar structure with UMP, a TS ligand, but folic acid which has lowest docking score is not similar with UMP. Conclusions: The 26 compounds, except folic acid, are more potent than 5-FU as TS inhibitors by docking study. Further study to delineate the effectivity of molecular docking is needed. Keywords: 5-Fluorouracil, herbal compound, molecular docking, thymidylate synthase
EATING VEGETABLES BEFORE CARBOHYDRATES DECREASE ENERGY INTAKE OF TYPE-2 DIABETES MELLITUS PATIENTS Dian Eka Widyasari; Sugiarto -; Dono Indarto
Media Gizi Indonesia Vol. 17 No. 1 (2022): JURNAL MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v17i1.51-55

Abstract

Diabetes mellitus is a non-communicable disease that has increased significantly in Indonesia and worldwide. Dietary arrangements through diet therapy are beneficial for improving the performance of the pancreas in producing and stimulating the work of insulin. This study aimed to determine the effect of the order of vegetable and carbohydrate consumptions on the decrease of energy intake. Method used randomized control trial with pre-post design.  A total of 24 people with non-complicating type-2 diabetes mellitus aged 18-65 years were assigned into 3 groups ; control group (C), vegetable before carbohydrate group (P1), and vegetable with carbohydrate group (P2) .  Energy intake before and after the intervention was measured using a 24-hour food recall. To compare pre-post intervention, paired T-test were used, meanwhile to compare difference among groups data were analysed using ANOVA.  A significant decrease in energy intake was found in P1 where the mean values of C and P1 were 17.75 ± 12.40 calories and 155.27 ± 23.40 calories (p < 0.001), and mean values of P1 and P2 were 155.27 ± 23.40 calories and 4.54 ± 48.99 calories (p < 0.001). The order of vegetable before carbohydrate consumption decreases energy intake of type-2 diabetes mellitus patients. 
Co-Authors Dian Eka Widyasari Ratna Oktaviani Sinu Andhi Jusup Sugiarto - Yoga Mulia Pratama Yuliana Heri Suselo