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Efek Glycine Soja Terhadap Angiogenesis dan Histologi Aorta Tikus Ovariektomi Dwi Yuliawati; Wuri Widi Astuti
Jurnal Kesehatan Andalas Vol 9, No 4 (2020): Online December 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1506

Resiko CVD meningkat secara tajam pada menopause yang disebabkan oleh perkembangan aterosklerosis ditandai adanya penebalan intima patologis pada aorta. Tujuan: Membuktikan pemberian ekstrak kedelai hitam (Glycine soja) dapat meningkatkan ekspresi VEGF, diameter aorta dan menurunkan ketebalan media intima aorta tikus ovariektomi. Ovariektomi dilakukan untuk membuat hewan model menopause. Metode: Tikus dibagi menjadi lima kelompok: Kontrol Negatif, Positif, tiga Perlakuan (dosis 50,100,150 mg/200grBB/hari). Ovariektomi dilakukan pada kelompok kontrol positif dan perlakuan.Tiga puluh hari post ovariektomi, pada kelompok perlakuan diberikan ekstrak kedelai hitam sesuai dosis selama 30 hari. Terminasi dilakukan untuk pengambilan aorta pada seluruh kelompok. Pemeriksaan ketebalan media intima dan diameter aorta menggunakan HE, sedangkan VEGF menggunakan immunohistokimia. Hasil: Uji One Way Anova terhadap diameter aorta dan VEGF, didapatkan p = 0,000 (p<0,05 ), yang berarti terdapat pengaruh signifikan pemberian ekstrak kedelai hitam terhadap peningkatan diameter dan VEGF aorta tikus ovariektomi. Uji Post Hock Tukey menunjukkan peningkatan diameter aorta dan VEGF signifikan pada seluruh kelompok perlakuan dibandingkan kelompok kontrol positif. Uji One Way Anova terhadap ketebalan media intima didapatkan p = 0,410, yang berarti tidak terdapat pengaruh yang signifikan pemberian ekstrak kedelai hitam terhadap penurunan ketebalan media intima aorta tikus ovariektomi. Rerata ketebalan terendah terdapat pada kelompok Perlakuan 1 dibawah rerata ketebalan media intima kelompok kontrol positif. Simpulan: Pemberian ekstrak kedelai hitam meningkatkan secara signifikan ekspresi VEGF dan diameter aorta, namun tidak berpengaruh secara signifikan dalam menurunkan ketebalan media intima aorta tikus ovariektomi.Kata kunci: diameter aorta, kedelai hitam, ketebalan media intima aorta, VEGF

Path Analysis of the Effect of Biological and Social Factors on the Case of Breast Cancer Nunik Ike Yunia Sari; Estin Gita Maringga; Wuri Widi Astuti
JURNAL INFO KESEHATAN Vol 17 No 2 (2019): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Breast cancer is the number one cancer as the cause of death in women in developed and developing countries. Breast cancer has the highest case in women in 161 countries. The objective of this study is to analyze the influence of biological and social factors on breast cancer cases in the Public Hospital of Kediri, East Java. The research design was analytic with a retrospective cohort approach. The research sample of 105 respondents used simple random sampling. Data collection was with medical records in January-December, 2017. Data analysis used the path analysis test. The test results obtained breast cancer is influenced by a history of hereditary breast cancer (b=0.17, p=0.001); menopause age (b=0.17, p=0.001); family planning history (b=0.11, p=0.014); parity (b=0.08, p=0.031); age (b=0.21, p=0.001); income (b=0.21, p=0.001). Parity was influenced by income (b=0.45, p <0.001). The age of menopause was influenced by a history of hereditary breast cancer (b= 0.31, p <0.001); family planning history (b=0.13, p=0.13); and age (b=0.10, p=0.01). It can be concluded that the case of breast cancer was directly influenced by hereditary cancer, family history of birth control, age, parity, menopausal age, and income. Also, breast cancer was indirectly affected by income through parity; and hereditary history of breast cancer, family planning history, and age through menopause.

Knowledge Affects the Participation of Women of Reproductive Age in the Use of Long-Term Contraceptive Methods Wuri Widi Astuti; Anik Soelistyowati; Dintya Ivantarina
Science Midwifery Vol 10 No 5 (2022): December: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i5.1015

The trend of acceptors of family planning in Indonesia so far shows less use of long-term contraceptive methods compared to short-term contraceptive methods. This may be due to limited knowledge or information obtained by women of childbearing age couples, so the aim of this study was to determine the relationship between knowledge and participation of women of childbearing age in the use of long-term contraceptive methods. This type of correlation analytic research was a cross-sectional approach that was carried out in May-2012. June 2022. The research population was all female couples of childbearing age who used active contraception in the Petiken hamlet, Petiken village, Driyorejo Gresik District, totaling 345 women with a total sample of 182 women who met the inclusion criteria through simple random sampling. The data collection method was carried out directly with a research instrument in the form of a questionnaire. Data were analyzed using the Chi-Square statistical test. The results showed that knowledge influenced the participation of women of childbearing age in the use of long-term contraceptive methods (P = 0.000). Knowledge is a very important domain in the formation of one's actions so that a good level of knowledge will determine behavior in the use of long-term contraceptive methods.

Pengetahuan dan Sikap Ibu Hamil Tentang Risiko Paparan Covid-19 Terhadap Persiapan Persalinan Pada Masa Pandemi Covid-19 Wuri Widi Astuti; Siti Asiyah
Prosiding SPIKesNas : Seminar Publikasi Ilmiah Kesehatan Nasional Vol. 1 No. 01 (2022): SPIKesNas - Agustus 2022
Publisher : STIKES dan AKZI Karya Husada Kediri

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During the Covid-19 pandemic, implementing health protocols according to government recommendations is one of the efforts to prevent the transmission of the virus that must be obeyed by all groups, including pregnant women. Pregnant women are a vulnerable group exposed to Covid-19 virus infection which can increase maternal and newborn morbidity and mortality. The purpose of the study was to analyze the relationship between knowledge and attitudes about the risk of exposure to Covid-19 with preparation for childbirth during the Covid-19 pandemic at the Wilangan Nganjuk Health Center. This type of research is a correlational study with a cross-sectional approach. The population is all third-trimester pregnant women at the Wilangan Nganjuk Health Center in October 2021 as many as 104 people, sampling was carried out for 2 weeks on October 2-16, 2021 by accidental sampling which obtained 56 people. Collecting data using a questionnaire sheet, then analyzed using Chi-Square statistical test with = 0.05. The results showed, that among 56 third trimester pregnant women, almost all of them had good knowledge, as many as 49 people (87.5%), most of them had a good attitude about the risk of exposure to Covid-19, namely 36 people (64.3%), most of them were ready. in preparing for childbirth during the Covid-19 Pandemic, as many as 34 people (70.7%). The results of the statistical test showed that there was a relationship between knowledge about the risk of exposure to Covid-19 and preparation for delivery of pregnant women in the third trimester with a p-value of = 0.012, and there was a relationship between attitudes and preparation for delivery of pregnant women in the third trimester with a p-value of = 0.024. Pregnant women can absorb information about Covid-19 to increase knowledge about the risk of exposure to Covid-19 so that it can be used as a prevention and control measure for Covid-19 so that pregnant women can go through pregnancy and childbirth in a healthy, safe, and no accompanying complication.

Deteksi Dini Resiko Tinggi Pada Ibu Hamil melalui program “Kemilau Penari”gi Pada Ibu Hamil melalui program “Kemilau Penari” Wuri Widi Astuti
Prosiding SPIKesNas : Seminar Publikasi Ilmiah Kesehatan Nasional Vol. 1 No. 01 (2022): SPIKesNas - Agustus 2022
Publisher : STIKES dan AKZI Karya Husada Kediri

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Pregnancy is a physiological condition and has great meaning in every woman's life. Although it is physiological in nature, the presence of diseases previously suffered by pregnant women or complications during pregnancy can cause complications for both the mother and the fetus in the womb. Therefore, it is necessary to make efforts to improve health, especially for pregnant women by detecting complications and high risks in pregnancy. The purpose of this activity is to improve education for pregnant women about early detection of high risks and complications in pregnancy by carrying out community service activities with the "Green Dancer" program. The target is 15 pregnant women TM III which will be held from 07-13 June 2022 at PMB Hj. Karwati, SST., BD Ngampel Village, Mojoroto District, Kediri City. The activity was carried out through 3 stages, namely the pre-test stage which aims to determine the extent of knowledge and understanding of high-risk mothers in pregnant women. The second stage is providing material on high risk early detection and how to assess risk scores using KSPR. The third stage is to evaluate the participants regarding the material that has been given by giving a post test and ending with the formation of a discussion group via Whatsapp. The results of the activities from the counseling were found that most of the mother's knowledge increased in the good category. Pregnant women can fill out and read scores in the KSPR, as well as form an educational group with the name 3K ON. With this innovation, it is hoped that it can help overcome the problems of pregnant women related to complications and can contribute to the reduction of MMR and IMR.

Peningkatan Pengetahuan pada Pasangan Calon Pengantin tentang Perencanaan Kehamilan melalui program “Secanting” Wuri Widi Astuti
Prosiding SPIKesNas : Seminar Publikasi Ilmiah Kesehatan Nasional Vol. 2 No. 1 (2023): SPIKesNas - Februari 2023
Publisher : STIKES dan AKZI Karya Husada Kediri

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Preconception is care before pregnancy with a span of three months to one year before conception. The "Secanting" program, which stands for “Sosialisasi dan Edukasi Calon Pengantin itu Penting” as a program for the bride and groom to receive education about physical and psychological health before facing marriage so that later they can prepare for the pregnancy process well to prevent malnutrition, prepare the body for changes during pregnancy. , prevent obesity, prevent the risk of miscarriage etc. The purpose of this activity is that participants are expected to know about Healthy Pregnancy Planning. The method used in this activity was to provide counseling to the prospective bride and groom as many as 10 participants, which was carried out at the Puncu Health Center, Puncu District, Kediri Regency on September 5-8, 2022. This activity was carried out in 3 stages, namely pre-testing, providing counseling and followed by a post test. The results of these activities indicate that there is an increase in the knowledge of the participants and the enthusiasm of the participants in participating in the extension activities. Providing information, especially health problems in the community, is very important, with the intensive information that is heard or obtained by individuals, it can increase the knowledge of the prospective bride and groom, especially about pregnancy planning.

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