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CLINICAL PRESENTATION, DIAGNOSIS AND TREATMENT OF PULMONARY FUNGUS BALL RELATED TUBERCULOSIS Fenty Anggrainy; Irvan Medison; Deddy Herman; Sabrina Ermayanti; Yessy Susanty Sabri
Jurnal Kesehatan Andalas Vol 8, No 2 (2019): Online Juni 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i2.1025

Fungus Ball paru merupakan komplikasi yang sering terjadi pada Tuberkulosis (TB) paru dengan kavitas, terutama pada bekas TB paru. Agen penyebab selain Aspergilus sp yaitu Candida sp. Terapi definitif untuk penyakit ini adalah terapi bedah. Pada kondisi khusus dapat digunakan tatalaksana lainnya. Penelitian ini mengevaluasi 6 pasien Fungus Ball paru dengan riwayat obat anti tuberkulosis, dengan beberapa metode diagnosis dari tahun 2010 sampai 2013. Tatalaksana dan hasil pengobatan pasien dianalisis pada penelitian ini. Hemoptisis terdapat pada seluruh pasien dan tiga diantaranya dengan hemoptisis masif. Semua pasien memiliki gambaran yang khas untuk Fungus Ball paru dari radiologi toraks. Spesies jamur terkonfirmasi pada 5 pasien: pemeriksaan serologis (1), kultur jamur (2) dan pemeriksaan histopatologi (2). Spesies yang didapatkan adalah Aspergilosis sp = 3, Candida paraspilosis = 1 dan Candida sp = 1. Dua pasien mendapatkan terapi bedah dengan tidak adanya keluhan hemoptisis setelah itu. Empat pasien yang hanya mendapatkan anti jamur, ternyata 75% memberikan respon yang baik secara klinis dan radiologis. Kavitas yang menetap pada TB paru dan bekas TB paru, dapat menimbulkan insiden Fungus Ball paru yang membutuhkan lobektomi sebagai terapi definitif. Pada kondisi tertentu dimana terapi pembedahan tidak dapat dilakukan, anti jamur dapat menjadi terapi alternatif dan memberikan hasil yang baik.

Gambaran Karakteristik Tingkat Kontrol Penderita Asma Berdasarkan Indeks Massa Tubuh (IMT) di Poli Paru RSUP. Dr. M. Djamil Padang pada Tahun 2016 Fanny Permata Andriani; Yessy Susanty Sabri; Fenty Anggrainy
Jurnal Kesehatan Andalas Vol 8, No 1 (2019): Online Maret 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i1.975

Asma adalah penyakit heterogen, yang ditandai dengan terjadinya inflamasi kronik saluran pernapasan. Salah satu faktor risiko asma yang berkaitan erat dengan kontrol asma adalah obesitas. Selain itu underweight juga terkait dengan fungsi paru yang menurun dan asma. Tujuan penelitian ini adalah menentukan gambaran karakteristik tingkat kontrol penderita asma berdasarkan indeks massa tubuh (IMT) di Poli Paru RSUP Dr. M. Djamil Padang pada tahun 2016. Jenis penelitian ini adalah deskriptif observasional restrospektif dengan menggunakan data rekam medis pasien asma rawat jalan di Poli Paru RSUP Dr. M. Djamil Padang antara 1 Januari sampai 31 Desember 2016 dan didapatkan sebanyak 63 data yang memenuhi kriteria sampel. Data diolah dengan menggunakan program komputer dan disajikan dalam bentuk tabel distribusi dan frekuensi. Hasil penelitian menunjukkan bahwa pasien asma laki-laki (49,2%) dan perempuan (50,8%) hampir merata, sebagian besar berusia 40 – 60 tahun (47,6%), bekerja sebagai PNS (31,7%), memiliki IMT ≥ 23,0 (49,2%), dengan tingkat kontrol asma berupa asma terkontrol sebagian (61,9%), asma terkontrol penuh terbanyak ditemukan pada IMT normal (3,2%), asma tidak terkontrol terbanyak pada IMT normal (17,5%), dan asma terkontrol sebagian terbanyak pada IMT berat badan lebih & obes (31,7%).

Overview of COVID-19 Vaccine Development Strategy Katerine Junaidi; Dewi Wahyu Fitrina; Fenty Anggrainy; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.473

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of coronavirus disease 20019 (COVID19) pandemic which first emerged in December 2019 in Wuhan city, China. Currently, a vaccine is urgently needed to control the COVID-19 pandemic. Several vaccine candidates are under development and some are in the final stage of clinical trials. The COVID-19 vaccination aims to reduce morbidity and mortality rates, achieve herd immunity to prevent and protect the society, strengthen the health system, maintain productivity and minimize social and economic impacts. Before approval, vaccines have to undergo several clinical trials to ensure its safety profile, efficacy, duration of immune system resistance, and adverse effect. Various strategies have been used in the development of vaccines including viral vector vaccines, nucleic acid vaccines, inactivated virus, live attenuated virus, subunit protein¸and virus-like particle vaccine. Each strategy has its own advantages and disadvantages.

Coal Workers' Pneumoconiosis at PT. A Sawahlunto and The Influencing Factors Ulfahimayati Ulfahimayati; Deddy Herman; Masrul Basyar; Fenty Anggrainyi
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.157

Background: Coal workers’s pneumoconiosis (black lung disease) is an interstitial lung disease caused by chronic inhalation of coal dust. The incidence of coal workers’s pneumoconiosis increased globally from the 1990s to the 2000s by 3.2%. Indonesia is the country which has many coal mining, but national prevalence of coal workers pneumoconiosis was not discovered. PT. A is one of mining companies in Sawahlunto. The aims of this study was to determine the incidence of coal workers’ pneumoconiosis at PT. A Sawahlunto and it’s influencing factors. Methods: This study is an analytic study with cross sectional design, conducted from November 2019 to April 2020. There were 90 coal miners participated in this study. All subjects were performed chest X-ray examination with ILO standard to asses the incidence of pneumoconiosis. Spirometr examination, dust level measurement with portable low volume air sampler, interview, and validated questionnare were performed to evaluate it’s influencing factors. Statistical analysis used Chi-square test and double logistic regression test. Results: This study found 12 workers (13.3%) had pneumoconiosis. From the statistical test results obtained age >50 years (P=0.035), duration of exposure (P=0.040), mask usage (P=0.029), restrictive lung function (P=0.004), and the mixed abnormality lung function (P=0.006) is associated with pneumoconiosis. The most dominant factor was mask usage (P=0.049) with OR=5.026 Conclusion: The most dominant factor that influence coal workers’ pneumoconiosis was mask usage. Others related factors were age, duration of exposure and abnormality lung function.

Overview of COVID-19 Vaccine Development Strategy Katerine Junaidi; Dewi Wahyu Fitrina; Fenty Anggrainy; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.473

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of coronavirus disease 20019 (COVID19) pandemic which first emerged in December 2019 in Wuhan city, China. Currently, a vaccine is urgently needed to control the COVID-19 pandemic. Several vaccine candidates are under development and some are in the final stage of clinical trials. The COVID-19 vaccination aims to reduce morbidity and mortality rates, achieve herd immunity to prevent and protect the society, strengthen the health system, maintain productivity and minimize social and economic impacts. Before approval, vaccines have to undergo several clinical trials to ensure its safety profile, efficacy, duration of immune system resistance, and adverse effect. Various strategies have been used in the development of vaccines including viral vector vaccines, nucleic acid vaccines, inactivated virus, live attenuated virus, subunit protein¸and virus-like particle vaccine. Each strategy has its own advantages and disadvantages.

Association between Obesity and COVID-19 Outcomes in the Intensive Care Unit of RSUP Dr. M. Djamil Padang Ilham Ilham; Fenty Anggrainy; Dessy Mizarti
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.342

Background: Obesity is one of the risk factors for severe clinical COVID-19. This is because these patients tend to have comorbidities such as metabolic disease and cardiovascular disease. Obesity may result in poor outcomes, such as prolonged hospital stays, higher incidence of ARDS and mortality. The purpose of this study was to determine the correlation between obesity and the outcome of confirmed COVID-19 patients.Methods: This was an analytical study with retrospective cohort design on COVID-19 patients treated in the intensive care unit (ICU)of RSUP Dr. M. Djamil Padang. Data were taken from patients’ medical records between November 2021 and February 2022. The correlation between obesity with length of stay and patient mortality was analyzed using Chi-square test. Odds ratio was also assessed.Results: This study obtained that the characteristics of obese COVID-19 patients were mainly women (54.20%). The most dominant age group was 60-69 years (31.3%). About83.3% of obese patients were found to be clinically critical. Inflammatory markers such as procalcitonin, ferritin, IL-6 and d-dimer were not significantly associated with obesity. Diabetes mellitus was significantly related to the outcome of COVID-19 patients with obesity and without obesity (0.009%). Obesity was not correlated with hospital length of stay of COVID-19 patients, but was significantly associated with length of stay in the ICU [OR 3.67 (95% CI, 1.09-12.35)]. Obesity was significantly associated with mortality [OR 2.84 (95% CI, 1.12-7.18)] and length of conversion for COVID-19 patients in the ICU [OR 30.00 (95% CI, 2.85-31, 61)]. The expansion of adipose tissue both subcutaneously and viscerally which could be observed in obese patients can increase the proinflammatory, prothrombotic, and vasoconstrictive state that might affect the clinical deterioration of COVID-19 patients. This condition also manifests as insulin resistance, hypertension, atherosclerosis, cardiovascular disease and immunocompromised conditions which can generate high mortality rate.Conclusion: Obesity was found to be significantly associated with mortality, conversion time and length of stay for COVID-19 patients in the ICU.

Posisi prone pada terapi oksigenasi pasien COVID-19 Merry Dhama Yanti; Fenty Anggrainy; Dewi Wahyu Fitrina
Majalah Kedokteran Andalas Vol 45, No 4 (2022): Online October 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i4.p642-654.2022

AbstrakPenyakit Coronavirus 2019 (COVID-19) yang dimulai sejak akhir tahun 2019 cepat menyebar di seluruh dunia hingga dinyatakn sebagai pandemi. Pneumonia menjadi alasan dirawatnya pasien COVID-19 dan memerlukan terapi oksigen. Pneumonia berat menyebabkan terjadinya hipoksemia akibat kegagalan respirasi yang dikenal dengan acute respiratory distress syndrome (ARDS). Posisi prone sudah dikenal sejak lama dapat digunakan sebagai terapi adjuvan untuk meningkatkan ventilasi pasien COVID-19 yang mengalami ARDS.Kata kunci: COVID-19, Pneumonia, Hipoksemia, ARDS, Posisi proneAbstractCoronavirus disease 2019 (COVID-19), which began at the end of 2019 rapidly spread around the world until it was declared as pandemic. Pneumonia is the reason for COVID-19 patients to hospitalized and requires oxygen therapy. Severe pneumonia causes hipoxemia due to respiratory failure which known as acute respiratory distress syndrome (ARDS). The prone position, which has been known for a long time can be used as an adjuvant therapy to improve ventilation for COVID-19 patients who suffrered ARDS.Keywords: COVID-19, Pneumonia, Hypoxemia, ARDS, Prone position

Pulmonary Embolism: A Narrative Literature Review Bobby Hasibuan; Oea Khairsyaf; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.705

Pulmonary embolism (PE) is a pulmonary emergency that is quite common with various clinical manifestations, from asymptomatic to life-threatening. The incidence of pulmonary embolism is reported to be 1 per 1000 population, with 50,000 deaths per year. Making the diagnosis is difficult because the symptoms vary widely in each patient. Management of acute pulmonary embolism is carried out with a systematic approach involving early intervention, patient risk stratification, selection of therapy, and determination of the length of treatment.

The Relationship Between Smoking Status and Smoking Index Against COVID-19 Disease Course in Treated Patients at Dr. M Djamil General Hospital, Padang Yulia Helexandra; Yessy Susanty Sabri; Fenty Anggrainy
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.58

Background: Smoking is a risk factor for the development and worsening of respiratory diseases, including COVID-19 infection. Smoking can increase the risk of the severity of COVID-19 by two times because in smokers there is an increase in the expression of the ACE-2 gene by 25% compared to non-smokers. The purpose of this study was to determine the relationship between smoking status and smoking index on the course of COVID-19 disease treated at Dr. M Djamil General Hospital. Method: An observational analytic study with a retrospective cohort approach on COVID-19 patients who were treated at Dr. M. Djamil General Hospital. Data were taken from January to March 2021. The relationship between smoking status and smoking index on the course of COVID-19 was analyzed by Chi-Square. Results: This study found the most age was above 50 years with a vulnerable age of 50-59 years (28.4%) and female gender (56.7%). Non-smoker status (64.2%) and moderate smoking index (51.4%) were the most commonly found in this study. Clinically non-progressive COVID-19 (53.7%) was the most common. This study found that the maximum length of stay for COVID-19 patients was less than 21 days (53.7%) and the outcome of patients recovered (62.2%). This study found a significant relationship between the smoking index on the clinical progress of COVID-19 patients and there was a significant relationship between smoking status and the outcome of COVID-19 patients. This study found that smoking status and the smoking index had no significant relationship with the length of stay of COVID-19 patients. Conclusion: Smoking status is related to outcomes in COVID-19 patients and the smoking index is related to a progression in COVID-19 patients treated at Dr. M. Djamil General Hospital.

Pulmonary Embolism: A Narrative Literature Review Bobby Hasibuan; Oea Khairsyaf; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.705

Pulmonary embolism (PE) is a pulmonary emergency that is quite common with various clinical manifestations, from asymptomatic to life-threatening. The incidence of pulmonary embolism is reported to be 1 per 1000 population, with 50,000 deaths per year. Making the diagnosis is difficult because the symptoms vary widely in each patient. Management of acute pulmonary embolism is carried out with a systematic approach involving early intervention, patient risk stratification, selection of therapy, and determination of the length of treatment.

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