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All Journal Indonesian Journal of Pharmaceutical Science and Technology
Witri Nuraeni
Center for Applied Nuclear Science and Technology – National Nuclear Energy Agency Jl. Tamansari 71-Bandung, 40132
Computer Science & IT Medicine & Pharmacology

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Biodistribution of 99mTc-HSA-nanoparticle in Lymphatic Node of Animal Model Induced by 7,12 Dimethylbenz(a)anthracene Rizky Juwita Sugiharti; Iim Halimah; Isa Mahendra; Witri Nuraeni; Maula Eka Sriyani; Eva Maria Widyasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 1 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.315 KB) | DOI: 10.24198/ijpst.v1i1.19146

Abstract

Breast cancer is one of the most common malignant tumors found in women and hasbecome as the second cause of death in women after cervical cancer.We successfully synthesizedtechnetium-99m labeled Human Serum Albumin nanoparticle(99mTc-HSA nanoparticle); a radiopharmaceuticalwhich potentially used for application in lymphoscintigraphytechnique for tracing lymphatic system.This study was aims to obtain pre-clinical data from 99mTc-HSA nanocolloidin Sprague Dawleyfemale ratsgiven7, 12-dimethylbenzeneanthracene (DMBA) - induced cell proliferation in the breast tissues.The rats are divided into two groups, one groupsaregiven DMBA and observed for 5, 8 and 12 weeks and the other group is without any treatment as control.Biodistribution study of 99mTc-HSA nanoparticlewas conducted to identify the accumulation of this agent in the popliteal and lumbar lymph nodes and the other tissuecompare to normal rats.  99mTc-HSA nanoparticleshown good accumulation in popliteal lymph node  2.90+1.32  %ID;  0.81 +  0.47 %IDand 1.04+0.46  %ID  at one hour post injectionin 5, 8  and 12 weeks respectively.The popliteal extraction (PE) was estimated with value 87.92 %, 74.07%, 71.79% in 5, 8 and 12 weeks respectively. This result showed that99mTc-HSA nanoparticleis very promising compound to be lymphoscintigraphyagentin detection of breast cancer.Key words: lymphoscintigraphy, 99mTc-HSA nanoparticle, breast cancer
Co-Authors Eva Maria Widyasari Iim Halimah Isa Mahendra Maula Eka Sriyani Rizky Juwita Sugiharti