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All Journal Indonesian Journal of Pharmaceutical Science and Technology Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Naniek Setiadi Radjab
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Computer Science & IT Materials Science & Nanotechnology Medicine & Pharmacology

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Tyrosinase Inhibition from Green Tea (Camellia sinensis (L.) Kuntze) gel Hanifah Rahmi; Supandi Supandi; Naniek Setiadi Radjab; Tiara Julianti
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.27145

Abstract

Green tea (Camellia sinensis (L.) Kuntze) leaf has polyphenol substance that able to inhibit tyrosinase enzyme. Tyrosinase enzyme is one of the essential components that can be initiated melanin formation on the skin (melanogenesis). The natural inhibitory enzyme can be utilized in cosmetics and medicinal industries as depigmentation agent. Green tea leaf was formulated in the dosage form of a gel with carbomer 934 as a gelling agent. This study aimed to determine the optimum concentration of carbomer 934 on green tea leaf extract gel that has an inhibitory tyrosinase activity. This research used three carbomer 934 concentration, there was 0.5%, 0.75%, and 1% respectively. Which every formula was evaluated during six weeks involve organoleptic, homogeneity, viscosity, pH, centrifuge, and freeze-thaw test (during six cycles). The optimum formula was evaluated tyrosinase activity used a spectrophotometer-vis. The results showed that the great concentration of carbomer 934 was contained on the first formula, which has not phase separation and 49.62 ppm of IC50 value. This research showed that green tea leaf extract gel with 0,5% carbomer 934 prevented tyrosinase activity. Keywords: Carbomer 934, gel, green tea leaf extract, inhibitory of tyrosinase
FORMULATIONS GEL OF TUNA BONE COLLAGEN (Thunnus albacares) WITH HPMC AS A GELLING AGENT ari widayanti; Desti Ayu Fauziah; Naniek Setiadi Radjab
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.344 KB)

Abstract

Tuna’s collagen may be applied to burns at 2%. To provide convenience in use it was made in drug form gel. HPMC is used as a gelling agent because it can form a gel that is clear and netral and has a viscosity that is stable in a long periode. This study aims to determine the effect of increase in the concentration of HPMC as a gelling agent in the gel formula. at a concentration of 3%, 4%, 5%, 6%, 7%. The resulting gel is then evaluated by the organoleptic test, homogeneity test, pH test, viscosity test, centrifugation test, and freeze thaw test. Result of statistical analysis ANOVA one way to test the viscosity of the significant difference in each formula. Based on the result of this study concluded that the increased concentration of HPMC as a gelling agent can increase the viscosity of bone collagen gel tuna.
Pengaruh Konsentrasi Natrium Alginat Terhadap Gel Ekstrak Daun Teh Hijau (Camellia Sinensis L.) Sebagai Inhibitor Tirosinase Hanifah Rahmi; Rizky Ramadhan; Naniek Setiadi Radjab
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 14 No. 02 Desember 2017
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v14i2.1904

Abstract

Daun teh hijau (Camellia sinensis L.) merupakan salah satu tanaman yang mengandung senyawa-senyawa polifenol seperti katekin dan galokatekin galat yang dapat digunakan sebagai inhibitor tirosinase. Dalam penelitian ini ekstrak daun teh hijau dibuat menjadi sediaan gel dengan menggunakan natrium alginat sebagai gelling agent. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi natrium alginat terhadap penghambatan tirosinase pada gel ekstrak daun teh hijau. Gel dibuat menjadi 3 formula dengan masing-masing konsentrasi natrium alginat sebesar 2%, 2,5%, 3%. Ekstraksi daun teh hijau dilakukan dengan cara refluks menggunakan pelarut metanol 50%. Hasil penelitian menunjukkan ketiga formula mempunyai nilai IC50 masing-masing sebesar 34,80 µg/ml, 23,27 µg/ml, 20,69 µg/ml. Kesimpulan penelitian ini, bahwa sediaan dengan natrium alginat 3% memberikan hasil penghambatan tirosinase yang paling baik dengan IC50 sebesar 20,69 µg/ml.
Co-Authors Ari Widayanti Desti Ayu Fauziah Hanifah Rahmi Hanifah Rahmi Rizky Ramadhan Supandi Tiara Julianti