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All Journal Indonesian Journal of Pharmaceutical Science and Technology
Ida Ayumiati
Departemen Analisis Farmasi dan Kimia Medisinal Fakultas Farmasi Universitas Padjadjaran, Jatinangor-Sumedang, 45363
Computer Science & IT Medicine & Pharmacology

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Modification of Extraction Methods on Determining Simeticone Suspension Using FTIR Method Ida Musfiroh; Aliya Nur Hasanah; Gia A. Faradiba; Ida Ayumiati; Mutakin Mutakin; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.555 KB) | DOI: 10.24198/ijpst.v6i3.22355

Abstract

Antacids dosage form are a class of drugs used to chemically bind and neutralize stomach acid. Simethicone is one of the antacids that works as an antiflatulant. In an effort to guarantee the quality of a preparation, a valid analysis method is needed that meets the validation parameters. This study aims to modified of extraction method of the simethicone content of suspension samples using the FTIR method. The methods include simethicone modification of extraction from suspension preparations with toluene solvents and hydrochloric acid (2:5) 3.35. Validation methods include: determination of precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ) at wave number 1261 cm-1 and determination of the content of samples of simethicone suspension. The results showed that linearity parameters with a correlation coefficient of 0.997 in a concentration range of 1000-10,000 ppm, precision with a value of KV <2%, LOD and LOQ, respectively 378.97 and 1250.59 ppm. The results of the determination of simethicone suspension samples indicate that this method met the requirements of the validation parameters.Keywords: Validation, Simethicone, Infrared Spectrophotometry, antacid
Co-Authors Aliya Nur Hasanah Gia A. Faradiba Ida Musfiroh Muchtaridi Muchtaridi Mutakin Mutakin