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All Journal Jurnal Farmasi Udayana Jurnal Farmasi Indonesia
Ilil Maidatuz Zulfa
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Studi Komparatif Efektivitas Seftriakson dibanding Kombinasi Seftriakson-Metronidazole dan Sefuroksim-Metronidazole pada Pasien Apendisitis yang Menjalani Apendiktomi Ilil Maidatuz Zulfa
Jurnal Farmasi Udayana Vol. 8, No. 2, Tahun 2019
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (428.012 KB) | DOI: 10.24843/JFU.2019.v08.i02.p07

Abstract

Appendicitis or inflammation of appendix still has high prevalence in Indonesia which reach 3236 cases in 2103 and increase at 4351 cases in 2014. Antibiotics are used in appendicitis to prevent surgical site infection (SSI) after appendictomy. Cephalosporins like ceftriaxone and cefuroxime are commonly used as monotherapy or in combination with imidazole. This study was aimed to compare the effectifity of antibiotics used in acute appendicitis non perforation using parameter length of hospital stay, discharge status, and amount of SSI occurence. An analytical observation was conduct retrospectively through acute appendicitis patient medical records with ICD k35.8 during 2018. A total of 39 medical records were analyzed. Of that, 25 patients received ceftriaxone monotherapy, 5 patients received combination of ceftriaxone and metronidazole, and 9 remaining received cefuroxime in combination with metronidazole. All antibiotics were administered intravenously and used as prophylaxis and continued as pasca appendictomy therapy. The average of hospital stay of that three antibiotics regimen showed that the patients received combination of cefuroxime and metronidazole had the shortest period (3.00 + 0,50 days) while based on discharge status, patients with ceftriaxone monotherapy were the most who discharged to home with complete recovery (64.00%). However, SSI occurence was only observed in patients received ceftriaxone monotherapy (2.00%). Statistical analysis showed that there is a significant different in the average of hospital stay and discharge status through three groups of antibiotics treatment (p-value 0,000; p-value 0,001). In conclusion, the three regimens of antibiotics are effective as prophylactic and post appendictomy in acute appendicitis. However, becuse of significant difference of hospital stay, antibiotics regimen selection should consider the cost and effectivity ratio analysis.
Oral Short-course Antibiotics Compliance Survey at Several Public Health Centres in Surabaya Ilil Maidatuz Zulfa; Widya Handayani
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.911

Abstract

Patients compliance is commonly occured in short-course antibiotics therapy. Patients compliance not only contributed to the therapeutics effect but also to prevent antibiotics resistance. Qualitatively, uncompliance in using antibiotics is affected by patients knowledge about antibiotics, improving symptomps, false in interpretating drug labels, activities, the lack of family suppor, and the lack of information given by healthcare provider. This study was aimed to observe patients compliance in using antibiotics assessed in how and howmany times they take their dosage, how they give interval between the doses, and whether they complete their course or not. The reasons behind their behaviour also investigated in this study. The survey was conducted at three public health centres in Surabaya. Patients who received short-course (3-5 days) antibiotics therapy were asked to participate in this study. The compliance was assessed using online developed self-assessment questionnaire containing 17 questions asking how they use their antibiotics and how many pills left sent in the last dosage day. The antibiotics prescription data was recorded as a refference in evaluating patients compliance. During research periods, a total of 100 patients were enrolled in this study. Of that, there were only 12.0% categoryzed as compliant. Most of patients did not give the same time interval between their doses (63,0%) and did not finished or prolonged their course (46,0%). The majority reasons behind their behaviour was feelings better or improving symptomps and simply forgot to take their antibiotics. A strengtnen in counselling and monitoring during their antibiotics course is needed in order to increase their compliance.
Potensi Interaksi Antar Obat dalam Peresepan Rawat Jalan Pasien Penyakit Jantung Akibat Hipertensi Ilil Maidatuz Zulfa; Yessy Asli Rahmawati; Putri Febri Anggraini
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1253

Abstract

Hypertension or high blood pressure have contributed to the occurrence of cardiovascular disease. One of its complication is the development of Hypertensive Heart Disease (HHD). HHD pharmacological treatments usually combine antihypertensive and other agents that lead to polypharmacy. The use of multiple medications or polypharmacy will increase the potential of drug-drug interactions (PDDIs) that affect the therapeutic effect and increase adverse events. This study was aimed to analyze the prevalence and predictor of the PDDIs among HHD patients prescriptions in order to prevent the adverse effects and optimalize the therapy management. A retrospective observational study was conducted on HHD outpatients prescriptions. Medscape Drug Interaction Checker application was used to identify PDDIs. The mechanism, severity, number of interaction per prescription and most common interaction pairs of PDDIs were documented. In addition, age, gender, and the number of drug prescribed were analyzed as predictors of PDDIs using logistic regression binomial test. A total of 100 HHD outpatients prescriptions was analyzed and 94 of them had PDDIs. Majority of prescriptions had 3-4 and >4 PDDIs (33.00% each). Total of PDDIs observed were 397 cases. Most of PDDIs happened in the pharmacodynamic phase (86.40%) and need to monitored closely (93.20%). The concomitant use of Candesartan and Bisoprolol was found to be the most commpon interaction pair (11,08%) that can lead to the raise of potassium serum levels. The result of predictors analysis showed that the higher number of drug prescribed the higher the risk of the occurrence of PDDIs respectively (p-value 0,005) which addition 1 drug item will increase the PDDIs 7,232 time higher. In conclusion, the higher number of drug prescribed the closer monitoring need for PDDIs. In addition, closely monitoring in the elevating of potassium serum levels and the symptoms of hyperkalemia are needed in the treatment of HHD outpatients
Co-Authors Putri Febri Anggraini Widya Handayani Yessy Asli Rahmawati